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The first Swedish H1N2 swine influenza virus isolate represents an uncommon reassortant.
Virol J 2009; 6:180VJ

Abstract

The European swine influenza viruses (SIVs) show considerable diversity comprising different types of H1N1, H3N2, and H1N2 strains. The intensifying full genome sequencing efforts reveal further reassortants within these subtypes. Here we report the identification of an uncommon reassortant variant of H1N2 subtype influenza virus isolated from a pig in a multisite herd where H1N2 swine influenza was diagnosed for the first time in Sweden during the winter of 2008-2009. The majority of the European H1N2 swine influenza viruses described so far possess haemagglutinin (HA) of the human-like H1N2 SIV viruses and the neuraminidase (NA) of either the European H1N2 or H3N2 SIV-like viruses. The Swedish isolate has an avian-like SIV HA and a H3N2 SIV-like NA, which is phylogenetically more closely related to H3N2 SIV NAs from isolates collected in the early '80s than to the NA of H3N2 origin of the H1N2 viruses isolated during the last decade, as depicted by some German strains, indicative of independent acquisition of the NA genes for these two types of reassortants. The internal genes proved to be entirely of avian-like SIV H1N1 origin. The prevalence of this SIV variant in pig populations needs to be determined, as well as the suitability of the routinely used laboratory reagents to analyze this strain.The description of this H1N2 SIV adds further information to influenza epidemiology and supports the necessity of surveillance for influenza viruses in pigs.

Authors+Show Affiliations

National Veterinary Institute, (SVA), Ulls väg 2B, SE-751 89 Uppsala, Sweden. adam.balint@bvf.slu.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19863790

Citation

Bálint, Adám, et al. "The First Swedish H1N2 Swine Influenza Virus Isolate Represents an Uncommon Reassortant." Virology Journal, vol. 6, 2009, p. 180.
Bálint A, Metreveli G, Widén F, et al. The first Swedish H1N2 swine influenza virus isolate represents an uncommon reassortant. Virol J. 2009;6:180.
Bálint, A., Metreveli, G., Widén, F., Zohari, S., Berg, M., Isaksson, M., ... Kiss, I. (2009). The first Swedish H1N2 swine influenza virus isolate represents an uncommon reassortant. Virology Journal, 6, p. 180. doi:10.1186/1743-422X-6-180.
Bálint A, et al. The First Swedish H1N2 Swine Influenza Virus Isolate Represents an Uncommon Reassortant. Virol J. 2009 Oct 28;6:180. PubMed PMID: 19863790.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The first Swedish H1N2 swine influenza virus isolate represents an uncommon reassortant. AU - Bálint,Adám, AU - Metreveli,Giorgi, AU - Widén,Frederik, AU - Zohari,Siamak, AU - Berg,Mikael, AU - Isaksson,Mats, AU - Renström,Lena Hm, AU - Wallgren,Per, AU - Belák,Sándor, AU - Segall,Thomas, AU - Kiss,István, Y1 - 2009/10/28/ PY - 2009/08/20/received PY - 2009/10/28/accepted PY - 2009/10/30/entrez PY - 2009/10/30/pubmed PY - 2010/2/5/medline SP - 180 EP - 180 JF - Virology journal JO - Virol. J. VL - 6 N2 - The European swine influenza viruses (SIVs) show considerable diversity comprising different types of H1N1, H3N2, and H1N2 strains. The intensifying full genome sequencing efforts reveal further reassortants within these subtypes. Here we report the identification of an uncommon reassortant variant of H1N2 subtype influenza virus isolated from a pig in a multisite herd where H1N2 swine influenza was diagnosed for the first time in Sweden during the winter of 2008-2009. The majority of the European H1N2 swine influenza viruses described so far possess haemagglutinin (HA) of the human-like H1N2 SIV viruses and the neuraminidase (NA) of either the European H1N2 or H3N2 SIV-like viruses. The Swedish isolate has an avian-like SIV HA and a H3N2 SIV-like NA, which is phylogenetically more closely related to H3N2 SIV NAs from isolates collected in the early '80s than to the NA of H3N2 origin of the H1N2 viruses isolated during the last decade, as depicted by some German strains, indicative of independent acquisition of the NA genes for these two types of reassortants. The internal genes proved to be entirely of avian-like SIV H1N1 origin. The prevalence of this SIV variant in pig populations needs to be determined, as well as the suitability of the routinely used laboratory reagents to analyze this strain.The description of this H1N2 SIV adds further information to influenza epidemiology and supports the necessity of surveillance for influenza viruses in pigs. SN - 1743-422X UR - https://www.unboundmedicine.com/medline/citation/19863790/The_first_Swedish_H1N2_swine_influenza_virus_isolate_represents_an_uncommon_reassortant_ L2 - https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-6-180 DB - PRIME DP - Unbound Medicine ER -