TY - JOUR T1 - Quantification of drugs of abuse and some stimulants in hair samples by liquid chromatography-electrospray ionization ion trap mass spectrometry. AU - Bucelli,Francesca, AU - Fratini,Angela, AU - Bavazzano,Paolo, AU - Comodo,Nicola, Y1 - 2009/10/08/ PY - 2009/04/21/received PY - 2009/09/15/revised PY - 2009/09/18/accepted PY - 2009/10/30/entrez PY - 2009/10/30/pubmed PY - 2010/3/3/medline SP - 3931 EP - 6 JF - Journal of chromatography. B, Analytical technologies in the biomedical and life sciences JO - J Chromatogr B Analyt Technol Biomed Life Sci VL - 877 IS - 31 N2 - A qualitative and quantitative method for the analysis of drugs of abuse (cocaine and benzoylecgonine, opiates) and some stimulants in human hair was developed and validated. Hair samples were incubated with phosphate buffer (pH 5.0), chosen as the extraction medium, extracted with Bond Elut Certify cartridges and analyzed by LC-MS-MS and LC-MS(3) as confirmation for positive results. The method proved to be specific, accurate and precise across the calibration range (0.1-30 ng/mg) where good linearity was observed. Total extraction recovery, intra-assay accuracy and precision, limits of detection and limits of quantitation were estimated. The method was successfully applied to the analysis of hair samples collected from drug abusers and it was suitable for routine analytical applications in the Antidoping Laboratory of Public Health Laboratory. SN - 1873-376X UR - https://www.unboundmedicine.com/medline/citation/19864191/Quantification_of_drugs_of_abuse_and_some_stimulants_in_hair_samples_by_liquid_chromatography_electrospray_ionization_ion_trap_mass_spectrometry_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1570-0232(09)00671-0 DB - PRIME DP - Unbound Medicine ER -