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Sequential esophageal motility studies after endoscopic injection sclerotherapy: a prospective investigation.
Am J Gastroenterol. 1991 Jan; 86(1):36-40.AJ

Abstract

To assess prospectively the effects of endoscopic intravariceal sclerosis (EIS) on esophageal function, we performed esophageal manometry on 13 cirrhotic patients before EIS, 24 h after the second session and 4 wk after the fourth session. EIS had no impact on lower esophageal sphincter pressure. However, a significant decrease in the amplitude of peristaltic waves was observed immediately post-EIS in the lower two-thirds of the esophagus. There was no modification of duration or velocity of progression of peristaltic waves. A four-fold increase in simultaneous contractions was observed early after EIS. These changes were reversible, as assessed by late esophageal testing after EIS. No correlations were demonstrated between esophageal motor parameters and doses of sclerosant. We conclude that sclerosant injection into the esophageal wall acutely impairs esophageal motility, but motor function is partially restored 4 wk after completion of EIS, suggesting that dysmotility is reversible.

Authors+Show Affiliations

Department of Surgery, Hospital Clinic i Provincial, Barcelona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1986552

Citation

Grande, L, et al. "Sequential Esophageal Motility Studies After Endoscopic Injection Sclerotherapy: a Prospective Investigation." The American Journal of Gastroenterology, vol. 86, no. 1, 1991, pp. 36-40.
Grande L, Planas R, Lacima G, et al. Sequential esophageal motility studies after endoscopic injection sclerotherapy: a prospective investigation. Am J Gastroenterol. 1991;86(1):36-40.
Grande, L., Planas, R., Lacima, G., Boix, J., Ros, E., Esteve, M., Morillas, R., & Gasull, M. A. (1991). Sequential esophageal motility studies after endoscopic injection sclerotherapy: a prospective investigation. The American Journal of Gastroenterology, 86(1), 36-40.
Grande L, et al. Sequential Esophageal Motility Studies After Endoscopic Injection Sclerotherapy: a Prospective Investigation. Am J Gastroenterol. 1991;86(1):36-40. PubMed PMID: 1986552.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sequential esophageal motility studies after endoscopic injection sclerotherapy: a prospective investigation. AU - Grande,L, AU - Planas,R, AU - Lacima,G, AU - Boix,J, AU - Ros,E, AU - Esteve,M, AU - Morillas,R, AU - Gasull,M A, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 36 EP - 40 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 86 IS - 1 N2 - To assess prospectively the effects of endoscopic intravariceal sclerosis (EIS) on esophageal function, we performed esophageal manometry on 13 cirrhotic patients before EIS, 24 h after the second session and 4 wk after the fourth session. EIS had no impact on lower esophageal sphincter pressure. However, a significant decrease in the amplitude of peristaltic waves was observed immediately post-EIS in the lower two-thirds of the esophagus. There was no modification of duration or velocity of progression of peristaltic waves. A four-fold increase in simultaneous contractions was observed early after EIS. These changes were reversible, as assessed by late esophageal testing after EIS. No correlations were demonstrated between esophageal motor parameters and doses of sclerosant. We conclude that sclerosant injection into the esophageal wall acutely impairs esophageal motility, but motor function is partially restored 4 wk after completion of EIS, suggesting that dysmotility is reversible. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/1986552/Sequential_esophageal_motility_studies_after_endoscopic_injection_sclerotherapy:_a_prospective_investigation_ DB - PRIME DP - Unbound Medicine ER -