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ON THE MECHANISM OF OPSONIN AND BACTERIOTROPIN ACTION : III. THE DEVELOPMENT AND EFFECT OF THE ANTIBODIES FOUND IN EXPERIMENTAL TUBERCULOSIS OF RABBITS.
J Exp Med 1929; 49(5):815-31JE

Abstract

Rabbits infected intravenously with virulent mammalian tubercle bacilli have in a majority of cases developed circulating antibodies to a slight but appreciable degree. The increase in titer was detected in one group of rabbits within the 2nd or 3rd week, in others during the 2nd month of infection. Rabbits with residual pulmonary foci, resulting from infection 6 months or more previously with human tubercle bacilli, on reinfection with bovine tubercle bacilli promptly developed circulating antibodies strikingly in excess of those found during the course of primary infection. Such antibodies were present 6 or 7 days after reinfection. The changes in titer during tuberculous infection as detected by the bacterial surface reactions and by phagocytosis were again, within the experimental error, in quantitative correspondence. The loss of phagocytosis-promoting power in heated normal serum involves an exception to this correspondence between surface and phagocytosis effects. This exception has already been discussed in an earlier paper (8).

Authors+Show Affiliations

Department of Pathology and the Henry Phipps Institute, University of Pennsylvania, Philadelphia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19869584

Citation

McCutcheon, M, et al. "ON the MECHANISM of OPSONIN and BACTERIOTROPIN ACTION : III. the DEVELOPMENT and EFFECT of the ANTIBODIES FOUND in EXPERIMENTAL TUBERCULOSIS of RABBITS." The Journal of Experimental Medicine, vol. 49, no. 5, 1929, pp. 815-31.
McCutcheon M, Strumia M, Mudd S, et al. ON THE MECHANISM OF OPSONIN AND BACTERIOTROPIN ACTION : III. THE DEVELOPMENT AND EFFECT OF THE ANTIBODIES FOUND IN EXPERIMENTAL TUBERCULOSIS OF RABBITS. J Exp Med. 1929;49(5):815-31.
McCutcheon, M., Strumia, M., Mudd, S., Mudd, E. B., & Lucké, B. (1929). ON THE MECHANISM OF OPSONIN AND BACTERIOTROPIN ACTION : III. THE DEVELOPMENT AND EFFECT OF THE ANTIBODIES FOUND IN EXPERIMENTAL TUBERCULOSIS OF RABBITS. The Journal of Experimental Medicine, 49(5), pp. 815-31.
McCutcheon M, et al. ON the MECHANISM of OPSONIN and BACTERIOTROPIN ACTION : III. the DEVELOPMENT and EFFECT of the ANTIBODIES FOUND in EXPERIMENTAL TUBERCULOSIS of RABBITS. J Exp Med. 1929 Apr 30;49(5):815-31. PubMed PMID: 19869584.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - ON THE MECHANISM OF OPSONIN AND BACTERIOTROPIN ACTION : III. THE DEVELOPMENT AND EFFECT OF THE ANTIBODIES FOUND IN EXPERIMENTAL TUBERCULOSIS OF RABBITS. AU - McCutcheon,M, AU - Strumia,M, AU - Mudd,S, AU - Mudd,E B, AU - Lucké,B, PY - 2009/10/30/entrez PY - 1929/4/30/pubmed PY - 1929/4/30/medline SP - 815 EP - 31 JF - The Journal of experimental medicine JO - J. Exp. Med. VL - 49 IS - 5 N2 - Rabbits infected intravenously with virulent mammalian tubercle bacilli have in a majority of cases developed circulating antibodies to a slight but appreciable degree. The increase in titer was detected in one group of rabbits within the 2nd or 3rd week, in others during the 2nd month of infection. Rabbits with residual pulmonary foci, resulting from infection 6 months or more previously with human tubercle bacilli, on reinfection with bovine tubercle bacilli promptly developed circulating antibodies strikingly in excess of those found during the course of primary infection. Such antibodies were present 6 or 7 days after reinfection. The changes in titer during tuberculous infection as detected by the bacterial surface reactions and by phagocytosis were again, within the experimental error, in quantitative correspondence. The loss of phagocytosis-promoting power in heated normal serum involves an exception to this correspondence between surface and phagocytosis effects. This exception has already been discussed in an earlier paper (8). SN - 0022-1007 UR - https://www.unboundmedicine.com/medline/citation/19869584/ON_THE_MECHANISM_OF_OPSONIN_AND_BACTERIOTROPIN_ACTION_:_III._THE_DEVELOPMENT_AND_EFFECT_OF_THE_ANTIBODIES_FOUND_IN_EXPERIMENTAL_TUBERCULOSIS_OF_RABBITS L2 - http://jem.rupress.org/cgi/pmidlookup?view=long&pmid=19869584 DB - PRIME DP - Unbound Medicine ER -