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ON THE MECHANISM OF OPSONIN AND BACTERIOTROPIN ACTION : IV. THE ISOELECTRIC POINTS OF CERTAIN SENSITIZED ANTIGENS.
J Gen Physiol 1930; 13(6):669-81JG

Abstract

Sensitization with increasing concentrations of homologous immune serum shifts the isoelectric point of the antigens studied progressively to the alkaline side. Antigens maximally sensitized with rabbit sera have shown isoelectric points of pH 5.6 to 5.8. The globulins precipitated or salted out of the same immune sera have been isoelectric at pH 5.1 to 5.2. The combination of antigen with antibody depends of course upon specific affinities; the surface properties of the sensitized antigen, agglutination and phagocytosis depend primarily upon the properties of the sensitizing serum substances combined with and deposited on the antigen surface.

Authors+Show Affiliations

The Henry Phipps Institute and the Department of Pathology of the University of Pennsylvania, Philadelphia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19872556

Citation

McCutcheon, M, et al. "ON the MECHANISM of OPSONIN and BACTERIOTROPIN ACTION : IV. the ISOELECTRIC POINTS of CERTAIN SENSITIZED ANTIGENS." The Journal of General Physiology, vol. 13, no. 6, 1930, pp. 669-81.
McCutcheon M, Mudd S, Strumia M, et al. ON THE MECHANISM OF OPSONIN AND BACTERIOTROPIN ACTION : IV. THE ISOELECTRIC POINTS OF CERTAIN SENSITIZED ANTIGENS. J Gen Physiol. 1930;13(6):669-81.
McCutcheon, M., Mudd, S., Strumia, M., & Lucké, B. (1930). ON THE MECHANISM OF OPSONIN AND BACTERIOTROPIN ACTION : IV. THE ISOELECTRIC POINTS OF CERTAIN SENSITIZED ANTIGENS. The Journal of General Physiology, 13(6), pp. 669-81.
McCutcheon M, et al. ON the MECHANISM of OPSONIN and BACTERIOTROPIN ACTION : IV. the ISOELECTRIC POINTS of CERTAIN SENSITIZED ANTIGENS. J Gen Physiol. 1930 Jul 20;13(6):669-81. PubMed PMID: 19872556.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - ON THE MECHANISM OF OPSONIN AND BACTERIOTROPIN ACTION : IV. THE ISOELECTRIC POINTS OF CERTAIN SENSITIZED ANTIGENS. AU - McCutcheon,M, AU - Mudd,S, AU - Strumia,M, AU - Lucké,B, PY - 2009/10/30/entrez PY - 1930/7/20/pubmed PY - 1930/7/20/medline SP - 669 EP - 81 JF - The Journal of general physiology JO - J. Gen. Physiol. VL - 13 IS - 6 N2 - Sensitization with increasing concentrations of homologous immune serum shifts the isoelectric point of the antigens studied progressively to the alkaline side. Antigens maximally sensitized with rabbit sera have shown isoelectric points of pH 5.6 to 5.8. The globulins precipitated or salted out of the same immune sera have been isoelectric at pH 5.1 to 5.2. The combination of antigen with antibody depends of course upon specific affinities; the surface properties of the sensitized antigen, agglutination and phagocytosis depend primarily upon the properties of the sensitizing serum substances combined with and deposited on the antigen surface. SN - 0022-1295 UR - https://www.unboundmedicine.com/medline/citation/19872556/ON_THE_MECHANISM_OF_OPSONIN_AND_BACTERIOTROPIN_ACTION_:_IV._THE_ISOELECTRIC_POINTS_OF_CERTAIN_SENSITIZED_ANTIGENS L2 - http://jgp.rupress.org/cgi/pmidlookup?view=long&pmid=19872556 DB - PRIME DP - Unbound Medicine ER -