[Particularities of arginase and NO-synthase pathways of L-arginine metabolism in leucocytes of peripheral blood of rats in conditions of chronic x-ray irradiation].Ukr Biokhim Zh (1999). 2009 Mar-Apr; 81(2):40-8.UB
Arginine takes part in many metabolic cell processes. It is not only involved in the dynamic cycle of interconversion with prolin and glutamine but also serves as a precursor for protein, nitric oxide, creatine, polyamines, agmatine and urea synthesis. Particularities of arginase and NO-synthase pathways of L-arginine conversion under the X-ray radiation in the leucocytes-radiosensitive cells of peripheral blood, under the per os administration of L-arginine and L-NAME (NG-nitro-L-arginine methyl ester) to rats were detected. It was shown that both L-arginine (arginase and NO-synthase main substrate) and L-NAME (nonspecific inhibitor of NO-synthase) had a positive correct influence on the organism in case of decreasing of NO overproduction under the X-ray radiation.