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Examination of some performance characteristics of breath alcohol measurements obtained with the intoxilyzer 8000C following social drinking conditions.
J Anal Toxicol 2009; 33(8):514-20JA

Abstract

The Intoxilyzer 8000C was used to measure breath alcohol concentration (BrAC) in 10 healthy subjects under social drinking conditions. Measurements commenced within 5 min of the end of drinking (EOD). For 14 blood-breath pairs, measured BrACs were compared to corresponding venous blood alcohol concentrations (vBAC) of samples drawn at least 30 min after EOD and within 5 min of the corresponding breath test. BAC was analyzed using an enzymatic method. Concentration differences between breath and blood (BrAC - vBAC) ranged from -32 to +3 mg/dL (untruncated BrAC) and from -32 to -4 mg/dL (truncated BrAC). The Invalid Sample message was actuated in five out of 23 BrAC profiles. In the remaining 18 samples, residual mouth alcohol was evaluated by comparing the maximum difference between successive (5 min apart) measurements (MID5) over 20-30 min after EOD with the precision of replicate BrAC values taken 30-40 min after EOD (5 mg/dL or less; precision unaffected by breath sample volume over the range of 2-3 L). MID5 values occurred within the first three measurements in 16/18 cases, indicative of a significant mouth alcohol effect. Thus, mandatory delays should be used with the Intoxilyzer 8000C prior to testing to minimize the probability of overestimation of BrAC due to mouth alcohol.

Authors+Show Affiliations

Forensic Toxicology Research Laboratory, Department of Forensic Science, Laurentian University, 935 Ramsey Lake Road, Sudbury, Ontario, Canada. jwatterson@laurentian.caNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19874661

Citation

Watterson, James H., and Kayla N. Ellefsen. "Examination of some Performance Characteristics of Breath Alcohol Measurements Obtained With the Intoxilyzer 8000C Following Social Drinking Conditions." Journal of Analytical Toxicology, vol. 33, no. 8, 2009, pp. 514-20.
Watterson JH, Ellefsen KN. Examination of some performance characteristics of breath alcohol measurements obtained with the intoxilyzer 8000C following social drinking conditions. J Anal Toxicol. 2009;33(8):514-20.
Watterson, J. H., & Ellefsen, K. N. (2009). Examination of some performance characteristics of breath alcohol measurements obtained with the intoxilyzer 8000C following social drinking conditions. Journal of Analytical Toxicology, 33(8), pp. 514-20.
Watterson JH, Ellefsen KN. Examination of some Performance Characteristics of Breath Alcohol Measurements Obtained With the Intoxilyzer 8000C Following Social Drinking Conditions. J Anal Toxicol. 2009;33(8):514-20. PubMed PMID: 19874661.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Examination of some performance characteristics of breath alcohol measurements obtained with the intoxilyzer 8000C following social drinking conditions. AU - Watterson,James H, AU - Ellefsen,Kayla N, PY - 2009/10/31/entrez PY - 2009/10/31/pubmed PY - 2010/1/6/medline SP - 514 EP - 20 JF - Journal of analytical toxicology JO - J Anal Toxicol VL - 33 IS - 8 N2 - The Intoxilyzer 8000C was used to measure breath alcohol concentration (BrAC) in 10 healthy subjects under social drinking conditions. Measurements commenced within 5 min of the end of drinking (EOD). For 14 blood-breath pairs, measured BrACs were compared to corresponding venous blood alcohol concentrations (vBAC) of samples drawn at least 30 min after EOD and within 5 min of the corresponding breath test. BAC was analyzed using an enzymatic method. Concentration differences between breath and blood (BrAC - vBAC) ranged from -32 to +3 mg/dL (untruncated BrAC) and from -32 to -4 mg/dL (truncated BrAC). The Invalid Sample message was actuated in five out of 23 BrAC profiles. In the remaining 18 samples, residual mouth alcohol was evaluated by comparing the maximum difference between successive (5 min apart) measurements (MID5) over 20-30 min after EOD with the precision of replicate BrAC values taken 30-40 min after EOD (5 mg/dL or less; precision unaffected by breath sample volume over the range of 2-3 L). MID5 values occurred within the first three measurements in 16/18 cases, indicative of a significant mouth alcohol effect. Thus, mandatory delays should be used with the Intoxilyzer 8000C prior to testing to minimize the probability of overestimation of BrAC due to mouth alcohol. SN - 1945-2403 UR - https://www.unboundmedicine.com/medline/citation/19874661/Examination_of_some_performance_characteristics_of_breath_alcohol_measurements_obtained_with_the_intoxilyzer_8000C_following_social_drinking_conditions_ L2 - https://academic.oup.com/jat/article-lookup/doi/10.1093/jat/33.8.514 DB - PRIME DP - Unbound Medicine ER -