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Hepatoprotective activity of ethanolic extracts of bark of Zanthoxylum armatum DC in CCl4 induced hepatic damage in rats.
J Ethnopharmacol. 2010 Feb 17; 127(3):777-80.JE

Abstract

AIM OF THE STUDY

Zanthoxylum armatum DC is described as a hepatoprotective in Ayurveda, the Indian system of medicine. However, there is no scientific basis or reports in the modern literature regarding its usefulness as a hepatoprotective agent. The present study was carried out to evaluate the hepatoprotective activity of ethanolic extract of bark of Zanthoxylum armatum DC in CCl(4) induced hepatotoxicity in male Wistar rats.

MATERIALS AND METHODS

Ethanolic extracts at doses of 100, 200, and 400mg/kg were administered orally once daily for 7 days. The hepatoprotective activity was assessed using various biochemical parameters like alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, serum bilirubin, total protein and serum antioxidant enzymes along with histopathological studies of liver tissue.

RESULTS

The substantially elevated serum enzymatic levels of serum transaminases, alkaline phosphatase and total bilirubin were significantly restored towards normalization by the extracts. Bark extracts significantly increased the levels of antioxidant enzymes: superoxide dismutase, catalase and glutathione. Phytochemical analysis revealed presence of isoquinoline alkaloid, berberine, as well as flavonoids and phenolic compounds, which have been known for their hepatoprotective activities.

CONCLUSIONS

Zanthoxylum armatum DC possesses significant protective effect against hepatotoxicity induced by CCl(4) which may be attributed to the individual or combined action of phytoconstituents present in it.

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Publisher Full Text

Authors+Show Affiliations

Ranawat L
Gitanjali Institute of Pharmacy, Udaipur, India.
Bhatt J
No affiliation info available
Patel J
No affiliation info available

MeSH

AnimalsAntioxidantsBerberineCarbon TetrachlorideChemical and Drug Induced Liver InjuryEnzymesFlavonoidsLiverMalePhenolsPhytotherapyPlant BarkPlant ExtractsProtective AgentsRatsRats, WistarZanthoxylum

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19874881

Citation

Ranawat, Lalitsingh, et al. "Hepatoprotective Activity of Ethanolic Extracts of Bark of Zanthoxylum Armatum DC in CCl4 Induced Hepatic Damage in Rats." Journal of Ethnopharmacology, vol. 127, no. 3, 2010, pp. 777-80.
Ranawat L, Bhatt J, Patel J. Hepatoprotective activity of ethanolic extracts of bark of Zanthoxylum armatum DC in CCl4 induced hepatic damage in rats. J Ethnopharmacol. 2010;127(3):777-80.
Ranawat, L., Bhatt, J., & Patel, J. (2010). Hepatoprotective activity of ethanolic extracts of bark of Zanthoxylum armatum DC in CCl4 induced hepatic damage in rats. Journal of Ethnopharmacology, 127(3), 777-80. https://doi.org/10.1016/j.jep.2009.10.019
Ranawat L, Bhatt J, Patel J. Hepatoprotective Activity of Ethanolic Extracts of Bark of Zanthoxylum Armatum DC in CCl4 Induced Hepatic Damage in Rats. J Ethnopharmacol. 2010 Feb 17;127(3):777-80. PubMed PMID: 19874881.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatoprotective activity of ethanolic extracts of bark of Zanthoxylum armatum DC in CCl4 induced hepatic damage in rats. AU - Ranawat,Lalitsingh, AU - Bhatt,Jigar, AU - Patel,Jagruti, Y1 - 2009/10/27/ PY - 2009/03/03/received PY - 2009/09/13/revised PY - 2009/10/15/accepted PY - 2009/10/31/entrez PY - 2009/10/31/pubmed PY - 2010/8/7/medline SP - 777 EP - 80 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 127 IS - 3 N2 - AIM OF THE STUDY: Zanthoxylum armatum DC is described as a hepatoprotective in Ayurveda, the Indian system of medicine. However, there is no scientific basis or reports in the modern literature regarding its usefulness as a hepatoprotective agent. The present study was carried out to evaluate the hepatoprotective activity of ethanolic extract of bark of Zanthoxylum armatum DC in CCl(4) induced hepatotoxicity in male Wistar rats. MATERIALS AND METHODS: Ethanolic extracts at doses of 100, 200, and 400mg/kg were administered orally once daily for 7 days. The hepatoprotective activity was assessed using various biochemical parameters like alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, serum bilirubin, total protein and serum antioxidant enzymes along with histopathological studies of liver tissue. RESULTS: The substantially elevated serum enzymatic levels of serum transaminases, alkaline phosphatase and total bilirubin were significantly restored towards normalization by the extracts. Bark extracts significantly increased the levels of antioxidant enzymes: superoxide dismutase, catalase and glutathione. Phytochemical analysis revealed presence of isoquinoline alkaloid, berberine, as well as flavonoids and phenolic compounds, which have been known for their hepatoprotective activities. CONCLUSIONS: Zanthoxylum armatum DC possesses significant protective effect against hepatotoxicity induced by CCl(4) which may be attributed to the individual or combined action of phytoconstituents present in it. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/19874881/Hepatoprotective_activity_of_ethanolic_extracts_of_bark_of_Zanthoxylum_armatum_DC_in_CCl4_induced_hepatic_damage_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(09)00675-8 DB - PRIME DP - Unbound Medicine ER -