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Q Fever.
Vet Microbiol. 2010 Jan 27; 140(3-4):297-309.VM

Abstract

Q fever is a zoonotic disease caused by the ubiquitous pathogen Coxiella burnetii responsible for acute and chronic clinical manifestations. Farm animals and pets are the main reservoirs of infection, and transmission to human beings is mainly accomplished through inhalation of contaminated aerosols. This illness is associated with a wide clinical spectrum, from asymptomatic or mildly symptomatic seroconversion to fatal disease. In humans Q fever can manifest as an acute disease (mainly as a self-limited febrile illness, pneumonia, or hepatitis) or as a chronic disease (mainly endocarditis), especially in patients with previous valvulopathy and to a lesser extent in immunocompromised hosts and in pregnant women. In contrast in animals, Q fever is in most cases, strikingly asymptomatic. The definite diagnosis of Q fever is made based on a significant increase in serum antibody titers, the determination of which often requires considerable time, and therefore patients must be monitored for a certain period. The treatment is effective and well tolerated, but must be adapted to the acute or chronic pattern with the tetracyclines to be considered the mainstay of antibiotic therapy. Several actions have been proposed to prevent and reduce the animal and environmental contamination. Vaccination of animals in infected flocks, as well as in uninfected ones close to them, with an efficient vaccine can prevent abortions and shedding of the bacteria.

Authors+Show Affiliations

Unité des Rickettsies, CNRS UMR 6020, IFR 48, Faculté de Médecine, Université de Méditerranée, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19875249

Citation

Angelakis, Emmanouil, and Didier Raoult. "Q Fever." Veterinary Microbiology, vol. 140, no. 3-4, 2010, pp. 297-309.
Angelakis E, Raoult D. Q Fever. Vet Microbiol. 2010;140(3-4):297-309.
Angelakis, E., & Raoult, D. (2010). Q Fever. Veterinary Microbiology, 140(3-4), 297-309. https://doi.org/10.1016/j.vetmic.2009.07.016
Angelakis E, Raoult D. Q Fever. Vet Microbiol. 2010 Jan 27;140(3-4):297-309. PubMed PMID: 19875249.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Q Fever. AU - Angelakis,Emmanouil, AU - Raoult,Didier, Y1 - 2009/08/08/ PY - 2008/11/28/received PY - 2009/07/03/revised PY - 2009/07/30/accepted PY - 2009/10/31/entrez PY - 2009/10/31/pubmed PY - 2010/3/31/medline SP - 297 EP - 309 JF - Veterinary microbiology JO - Vet Microbiol VL - 140 IS - 3-4 N2 - Q fever is a zoonotic disease caused by the ubiquitous pathogen Coxiella burnetii responsible for acute and chronic clinical manifestations. Farm animals and pets are the main reservoirs of infection, and transmission to human beings is mainly accomplished through inhalation of contaminated aerosols. This illness is associated with a wide clinical spectrum, from asymptomatic or mildly symptomatic seroconversion to fatal disease. In humans Q fever can manifest as an acute disease (mainly as a self-limited febrile illness, pneumonia, or hepatitis) or as a chronic disease (mainly endocarditis), especially in patients with previous valvulopathy and to a lesser extent in immunocompromised hosts and in pregnant women. In contrast in animals, Q fever is in most cases, strikingly asymptomatic. The definite diagnosis of Q fever is made based on a significant increase in serum antibody titers, the determination of which often requires considerable time, and therefore patients must be monitored for a certain period. The treatment is effective and well tolerated, but must be adapted to the acute or chronic pattern with the tetracyclines to be considered the mainstay of antibiotic therapy. Several actions have been proposed to prevent and reduce the animal and environmental contamination. Vaccination of animals in infected flocks, as well as in uninfected ones close to them, with an efficient vaccine can prevent abortions and shedding of the bacteria. SN - 1873-2542 UR - https://www.unboundmedicine.com/medline/citation/19875249/Q_Fever_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-1135(09)00338-1 DB - PRIME DP - Unbound Medicine ER -