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[Inhibition of soy isoflavone intake on bone loss in menopausal women: evaluated by meta-analysis of randomized controlled trials].
Wei Sheng Yan Jiu 2009; 38(5):546-51WS

Abstract

OBJECTIVE

To clarify the effects of soy isoflavone intake on bone loss, meta-analysis of randomized controlled trials (RCTs) was performed.

METHODS

RCTs that observed the effects of soy isoflavone intake on urinary deoxypyridinoline (Dpyr), serum bone-specific alkaline phosphatase (BAP), and spine bone mineral density (SBMD) were searched by MEDLINE, CNKI, and so on. Meta-analysis for the RCTs selected in the analysis was performed.

RESULTS

Eighteen studies with a total of 978 subjects were selected for the analysis. The urinary Dpyr concentration in subjects who consumed isoflavones significantly decreased by - 2.08 nmol/mmol (95% CI: -3.82 - 0.34) in comparison to that in subjects who did not consume isoflavones. However, isoflavone intake significantly increased serum BAP by 1.48 microg/L (95% CI: 0.22 - 2.75). The SBMD in subjects who consumed isoflavones increased significantly by 20.6 mg/cm2 (95% CI: 4.5 - 36.6). Subjects who consumed isoflavone more than 90 mg/day and or 6 months increased SBMD as 28.5 mg/cm2 (95% CI: 8.4 - 48.6) and 27 mg/cm2 (95% CI: 8.3 - 45.8), respectively.

CONCLUSION

It was suggested that the bone loss in menopausal women attenuated by isoflavone intervention could be associated with inhibition of bone resorption and stimulation of bone formation.

Authors+Show Affiliations

Department of Social Medicine & Health Education, School of Public Health, Peking University, Beijing 100191, China. defuma2008@hotmail.com

Pub Type(s)

English Abstract
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

19877511

Citation

Ma, Defu, et al. "[Inhibition of Soy Isoflavone Intake On Bone Loss in Menopausal Women: Evaluated By Meta-analysis of Randomized Controlled Trials]." Wei Sheng Yan Jiu = Journal of Hygiene Research, vol. 38, no. 5, 2009, pp. 546-51.
Ma D, Qin L, Liu B, et al. [Inhibition of soy isoflavone intake on bone loss in menopausal women: evaluated by meta-analysis of randomized controlled trials]. Wei Sheng Yan Jiu. 2009;38(5):546-51.
Ma, D., Qin, L., Liu, B., & Wang, P. (2009). [Inhibition of soy isoflavone intake on bone loss in menopausal women: evaluated by meta-analysis of randomized controlled trials]. Wei Sheng Yan Jiu = Journal of Hygiene Research, 38(5), pp. 546-51.
Ma D, et al. [Inhibition of Soy Isoflavone Intake On Bone Loss in Menopausal Women: Evaluated By Meta-analysis of Randomized Controlled Trials]. Wei Sheng Yan Jiu. 2009;38(5):546-51. PubMed PMID: 19877511.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Inhibition of soy isoflavone intake on bone loss in menopausal women: evaluated by meta-analysis of randomized controlled trials]. AU - Ma,Defu, AU - Qin,Liqiang, AU - Liu,Baohua, AU - Wang,Peiyu, PY - 2009/11/3/entrez PY - 2009/11/3/pubmed PY - 2012/8/24/medline SP - 546 EP - 51 JF - Wei sheng yan jiu = Journal of hygiene research JO - Wei Sheng Yan Jiu VL - 38 IS - 5 N2 - OBJECTIVE: To clarify the effects of soy isoflavone intake on bone loss, meta-analysis of randomized controlled trials (RCTs) was performed. METHODS: RCTs that observed the effects of soy isoflavone intake on urinary deoxypyridinoline (Dpyr), serum bone-specific alkaline phosphatase (BAP), and spine bone mineral density (SBMD) were searched by MEDLINE, CNKI, and so on. Meta-analysis for the RCTs selected in the analysis was performed. RESULTS: Eighteen studies with a total of 978 subjects were selected for the analysis. The urinary Dpyr concentration in subjects who consumed isoflavones significantly decreased by - 2.08 nmol/mmol (95% CI: -3.82 - 0.34) in comparison to that in subjects who did not consume isoflavones. However, isoflavone intake significantly increased serum BAP by 1.48 microg/L (95% CI: 0.22 - 2.75). The SBMD in subjects who consumed isoflavones increased significantly by 20.6 mg/cm2 (95% CI: 4.5 - 36.6). Subjects who consumed isoflavone more than 90 mg/day and or 6 months increased SBMD as 28.5 mg/cm2 (95% CI: 8.4 - 48.6) and 27 mg/cm2 (95% CI: 8.3 - 45.8), respectively. CONCLUSION: It was suggested that the bone loss in menopausal women attenuated by isoflavone intervention could be associated with inhibition of bone resorption and stimulation of bone formation. SN - 1000-8020 UR - https://www.unboundmedicine.com/medline/citation/19877511/[Inhibition_of_soy_isoflavone_intake_on_bone_loss_in_menopausal_women:_evaluated_by_meta_analysis_of_randomized_controlled_trials]_ DB - PRIME DP - Unbound Medicine ER -