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Relationship between periodontitis and hepatic abnormalities in young adults.
Acta Odontol Scand. 2010 Jan; 68(1):27-33.AO

Abstract

OBJECTIVE

Obesity has been implicated as a risk factor for periodontitis and non-alcoholic fatty liver disease (NAFLD). In NAFLD, elevated alanine aminotransferase (ALT) is associated with obesity. Although a possible interrelationship between liver function and periodontitis has been reported among the middle-aged population, the correlation in young adults is little known. This study was designed to investigate the relationship between ALT and the presence of periodontitis in university students in Japan.

MATERIAL AND METHODS

Medical and oral health data were collected in a cross-sectional examination conducted by the Health Service Center of Okayama University. Systemically healthy, non-smoking students aged 18 and 19 years old (n = 2225) were included. The protocol of the United States National Health and Nutrition Examination Survey was applied. Subjects with probing pocket depth >or= 4 mm were defined as having periodontitis. Logistic regression analysis was used to estimate the association between ALT, body mass index and periodontitis.

RESULTS

The number of subjects with periodontitis was 104 (4.7%). In males, having periodontitis was significantly associated with an increased level of ALT (>or= 41 IU/l) in logistic regression analysis (adjusted odds ratio 2.3; 95% confidence interval 1.0-5.2; p < 0.05). However, there was no significant association between periodontitis and ALT in female students.

CONCLUSIONS

Elevated ALT could be a potential risk indicator for periodontitis among young males. Monitoring hepatic abnormalities to prevent periodontitis must be better understood, even in the young adult population.

Authors+Show Affiliations

Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kita-ku, Okayama, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19878045

Citation

Furuta, Michiko, et al. "Relationship Between Periodontitis and Hepatic Abnormalities in Young Adults." Acta Odontologica Scandinavica, vol. 68, no. 1, 2010, pp. 27-33.
Furuta M, Ekuni D, Yamamoto T, et al. Relationship between periodontitis and hepatic abnormalities in young adults. Acta Odontol Scand. 2010;68(1):27-33.
Furuta, M., Ekuni, D., Yamamoto, T., Irie, K., Koyama, R., Sanbe, T., Yamanaka, R., Morita, M., Kuroki, K., & Tobe, K. (2010). Relationship between periodontitis and hepatic abnormalities in young adults. Acta Odontologica Scandinavica, 68(1), 27-33. https://doi.org/10.3109/00016350903291913
Furuta M, et al. Relationship Between Periodontitis and Hepatic Abnormalities in Young Adults. Acta Odontol Scand. 2010;68(1):27-33. PubMed PMID: 19878045.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between periodontitis and hepatic abnormalities in young adults. AU - Furuta,Michiko, AU - Ekuni,Daisuke, AU - Yamamoto,Tatsuo, AU - Irie,Koichiro, AU - Koyama,Reiko, AU - Sanbe,Toshihiro, AU - Yamanaka,Reiko, AU - Morita,Manabu, AU - Kuroki,Kiyomi, AU - Tobe,Kazuo, PY - 2009/11/3/entrez PY - 2009/11/3/pubmed PY - 2010/3/5/medline SP - 27 EP - 33 JF - Acta odontologica Scandinavica JO - Acta Odontol Scand VL - 68 IS - 1 N2 - OBJECTIVE: Obesity has been implicated as a risk factor for periodontitis and non-alcoholic fatty liver disease (NAFLD). In NAFLD, elevated alanine aminotransferase (ALT) is associated with obesity. Although a possible interrelationship between liver function and periodontitis has been reported among the middle-aged population, the correlation in young adults is little known. This study was designed to investigate the relationship between ALT and the presence of periodontitis in university students in Japan. MATERIAL AND METHODS: Medical and oral health data were collected in a cross-sectional examination conducted by the Health Service Center of Okayama University. Systemically healthy, non-smoking students aged 18 and 19 years old (n = 2225) were included. The protocol of the United States National Health and Nutrition Examination Survey was applied. Subjects with probing pocket depth >or= 4 mm were defined as having periodontitis. Logistic regression analysis was used to estimate the association between ALT, body mass index and periodontitis. RESULTS: The number of subjects with periodontitis was 104 (4.7%). In males, having periodontitis was significantly associated with an increased level of ALT (>or= 41 IU/l) in logistic regression analysis (adjusted odds ratio 2.3; 95% confidence interval 1.0-5.2; p < 0.05). However, there was no significant association between periodontitis and ALT in female students. CONCLUSIONS: Elevated ALT could be a potential risk indicator for periodontitis among young males. Monitoring hepatic abnormalities to prevent periodontitis must be better understood, even in the young adult population. SN - 1502-3850 UR - https://www.unboundmedicine.com/medline/citation/19878045/Relationship_between_periodontitis_and_hepatic_abnormalities_in_young_adults_ L2 - https://www.tandfonline.com/doi/full/10.3109/00016350903291913 DB - PRIME DP - Unbound Medicine ER -