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The association of ocular blood flow with haemorheological parameters in primary open-angle and exfoliative glaucoma.
Acta Ophthalmol. 2011 Aug; 89(5):429-34.AO

Abstract

PURPOSE

To evaluate the ocular blood flow velocities and haemorheological parameters in patients with primary open-angle glaucoma (POAG), exfoliative glaucoma (XFG) and exfoliation syndrome (XFS) and to compare their results with those of healthy controls.

METHODS

Twenty-five patients with POAG (group 1), 25 patients with XFG (group 2), 25 patients with XFS (group 3) and 25 healthy controls (group 4) were included in the study. Ocular blood flow velocities of ophthalmic artery (OA), central retinal artery (CRA) and short posterior ciliary arteries (SPCAs) were measured using colour Doppler imaging (CDI). Haemorheological parameters (erythrocyte elongation and aggregation index, aggregation amplitude, aggregation half-life, plasma viscosity, haematocrit) were measured in venous blood samples of all patients.

RESULTS

The peak systolic velocity (PSV) and end-diastolic velocity (EDV) values were lower and resistive indices (RI) were higher for the OA, CRA and SPCA of glaucomatous (groups 1 and 2) patients compared with those of controls (group 4) (PSV: OA, 40.4 ± 11.3 versus 52.6 ± 12.8 cm/second, p < 0.001; CRA, 12.9 ± 2.9 versus 15.3 ± 4.2 cm/second, p = 0.02; SPCA, 21.7 ± 6.6 versus 26.6 ± 8.3 cm/second, p = 0.013) (EDV: OA, 10.3 ± 4.3 versus 14.2 ± 5.1 cm/second, p < 0.001; CRA, 3.7 ± 1.1 versus 4.5 ± 1.3 cm/second, p = 0.025; SPCA, 5.2 ± 1.8 versus 7.7 ± 3.2 cm/second, p = 0.001) (RI: OA, 0.75 ± 0.05 versus 0.66 ± 0.07, p < 0.001; CRA, 0.73 ± 0.08 versus 0.68 ± 0.10, p = 0.223; SPCA, 0.70 ± 0.10 versus 0.63 ± 0.11, p = 0.004). There were no statistically significant differences between the haemorheological parameters of glaucomatous and non-glaucomatous patients. The reduction in ocular blood flow velocities in groups 1, 2 and 3 were not associated with changes in haemorheological parameters.

CONCLUSION

Our results suggest that impairment of the retrobulbar blood flow in POAG and XFG is not associated with alterations in haemorheological parameters.

Authors+Show Affiliations

Department of Ophthalmology, Hacettepe University School of Medicine, Ankara, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19878104

Citation

Sekeroglu, Mehmet Ali, et al. "The Association of Ocular Blood Flow With Haemorheological Parameters in Primary Open-angle and Exfoliative Glaucoma." Acta Ophthalmologica, vol. 89, no. 5, 2011, pp. 429-34.
Sekeroglu MA, Irkec M, Mocan MC, et al. The association of ocular blood flow with haemorheological parameters in primary open-angle and exfoliative glaucoma. Acta Ophthalmol. 2011;89(5):429-34.
Sekeroglu, M. A., Irkec, M., Mocan, M. C., Ileri, E., Dikmenoglu, N., Seringec, N., Karaosmanoglu, D., & Orhan, M. (2011). The association of ocular blood flow with haemorheological parameters in primary open-angle and exfoliative glaucoma. Acta Ophthalmologica, 89(5), 429-34. https://doi.org/10.1111/j.1755-3768.2009.01713.x
Sekeroglu MA, et al. The Association of Ocular Blood Flow With Haemorheological Parameters in Primary Open-angle and Exfoliative Glaucoma. Acta Ophthalmol. 2011;89(5):429-34. PubMed PMID: 19878104.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association of ocular blood flow with haemorheological parameters in primary open-angle and exfoliative glaucoma. AU - Sekeroglu,Mehmet Ali, AU - Irkec,Murat, AU - Mocan,Mehmet Cem, AU - Ileri,Esin, AU - Dikmenoglu,Neslihan, AU - Seringec,Nurten, AU - Karaosmanoglu,Devrim, AU - Orhan,Mehmet, Y1 - 2009/10/29/ PY - 2009/11/3/entrez PY - 2009/11/3/pubmed PY - 2011/12/13/medline SP - 429 EP - 34 JF - Acta ophthalmologica JO - Acta Ophthalmol VL - 89 IS - 5 N2 - PURPOSE: To evaluate the ocular blood flow velocities and haemorheological parameters in patients with primary open-angle glaucoma (POAG), exfoliative glaucoma (XFG) and exfoliation syndrome (XFS) and to compare their results with those of healthy controls. METHODS: Twenty-five patients with POAG (group 1), 25 patients with XFG (group 2), 25 patients with XFS (group 3) and 25 healthy controls (group 4) were included in the study. Ocular blood flow velocities of ophthalmic artery (OA), central retinal artery (CRA) and short posterior ciliary arteries (SPCAs) were measured using colour Doppler imaging (CDI). Haemorheological parameters (erythrocyte elongation and aggregation index, aggregation amplitude, aggregation half-life, plasma viscosity, haematocrit) were measured in venous blood samples of all patients. RESULTS: The peak systolic velocity (PSV) and end-diastolic velocity (EDV) values were lower and resistive indices (RI) were higher for the OA, CRA and SPCA of glaucomatous (groups 1 and 2) patients compared with those of controls (group 4) (PSV: OA, 40.4 ± 11.3 versus 52.6 ± 12.8 cm/second, p < 0.001; CRA, 12.9 ± 2.9 versus 15.3 ± 4.2 cm/second, p = 0.02; SPCA, 21.7 ± 6.6 versus 26.6 ± 8.3 cm/second, p = 0.013) (EDV: OA, 10.3 ± 4.3 versus 14.2 ± 5.1 cm/second, p < 0.001; CRA, 3.7 ± 1.1 versus 4.5 ± 1.3 cm/second, p = 0.025; SPCA, 5.2 ± 1.8 versus 7.7 ± 3.2 cm/second, p = 0.001) (RI: OA, 0.75 ± 0.05 versus 0.66 ± 0.07, p < 0.001; CRA, 0.73 ± 0.08 versus 0.68 ± 0.10, p = 0.223; SPCA, 0.70 ± 0.10 versus 0.63 ± 0.11, p = 0.004). There were no statistically significant differences between the haemorheological parameters of glaucomatous and non-glaucomatous patients. The reduction in ocular blood flow velocities in groups 1, 2 and 3 were not associated with changes in haemorheological parameters. CONCLUSION: Our results suggest that impairment of the retrobulbar blood flow in POAG and XFG is not associated with alterations in haemorheological parameters. SN - 1755-3768 UR - https://www.unboundmedicine.com/medline/citation/19878104/The_association_of_ocular_blood_flow_with_haemorheological_parameters_in_primary_open_angle_and_exfoliative_glaucoma_ L2 - https://doi.org/10.1111/j.1755-3768.2009.01713.x DB - PRIME DP - Unbound Medicine ER -