Citation
Margaritopoulos, Giorgos A., et al. "Upregulation of Stromal Cell Derived Factor-1alpha in Collagen Vascular Diseases-associated Interstitial Pneumonias (CVDs-IPs)." Pulmonary Pharmacology & Therapeutics, vol. 23, no. 2, 2010, pp. 115-20.
Margaritopoulos GA, Antoniou KM, Soufla G, et al. Upregulation of stromal cell derived factor-1alpha in collagen vascular diseases-associated interstitial pneumonias (CVDs-IPs). Pulm Pharmacol Ther. 2010;23(2):115-20.
Margaritopoulos, G. A., Antoniou, K. M., Soufla, G., Karagiannis, K., Proklou, A., Lasithiotaki, I., Tzanakis, N., Spandidos, D. A., & Siafakas, N. M. (2010). Upregulation of stromal cell derived factor-1alpha in collagen vascular diseases-associated interstitial pneumonias (CVDs-IPs). Pulmonary Pharmacology & Therapeutics, 23(2), 115-20. https://doi.org/10.1016/j.pupt.2009.10.008
Margaritopoulos GA, et al. Upregulation of Stromal Cell Derived Factor-1alpha in Collagen Vascular Diseases-associated Interstitial Pneumonias (CVDs-IPs). Pulm Pharmacol Ther. 2010;23(2):115-20. PubMed PMID: 19878731.
TY - JOUR
T1 - Upregulation of stromal cell derived factor-1alpha in collagen vascular diseases-associated interstitial pneumonias (CVDs-IPs).
AU - Margaritopoulos,Giorgos A,
AU - Antoniou,Katerina M,
AU - Soufla,Giannoula,
AU - Karagiannis,Konstantinos,
AU - Proklou,Athanasia,
AU - Lasithiotaki,Ismini,
AU - Tzanakis,Nikolaos,
AU - Spandidos,Demetrios A,
AU - Siafakas,Nikolaos M,
Y1 - 2009/10/28/
PY - 2009/05/19/received
PY - 2009/10/08/revised
PY - 2009/10/21/accepted
PY - 2009/11/3/entrez
PY - 2009/11/3/pubmed
PY - 2010/5/4/medline
SP - 115
EP - 20
JF - Pulmonary pharmacology & therapeutics
JO - Pulm Pharmacol Ther
VL - 23
IS - 2
N2 - OBJECTIVE: We speculated that distinct angiogenic profiles are involved in idiopathic interstitial pneumonias (IIPs) in comparison with interstitial pneumonias associated with collagen vascular disease (CVD-IPs). This hypothesis was investigated by measuring the expression of a cardinal biologic axis, the vascular endothelial growth factor (VEGF)-stromal derived growth factor [SDF-1alpha, transcripts 1 and 2 (TR1 and TR2)] and receptor, CXCR4 and the angiogenetic receptors CXCR2 and CXCR3 in bronchoalveolar lavage fluid (BALF) in both conditions. METHODS: We studied prospectively 25 patients with fibrotic IIPs (f-IIPs) [20 with idiopathic pulmonary fibrosis (IPF) and 5 with idiopathic non-specific interstitial pneumonia (NSIP)] and 16 patients with CVD-IPs. mRNA expression was measured by Real-Time RT-PCR and protein was evaluated by Western Blotting. RESULTS: A significantly greater value has been detected in SDF-1alpha-TR1 mRNA expression levels of CVD-IPs (p=0.05) in comparison with IPF group. A similar trend has been also detected in protein expression in favor of CVD-IP group. In addition, VEGF mRNA levels have been found significantly increased in CVD-IPs in comparison with the NSIP group (p=0.05). No significant difference has been found in SDF-1alpha-TR2-CXCR4 mRNA and CXCR2-CXCR3 between the two groups. CONCLUSION: These results showed increased expression of SDF-1alpha in CVD-IPs, suggesting different angiogenic procedures. Further studies are needed in order to better explore the angiogenetic pathway in these disorders.
SN - 1522-9629
UR - https://www.unboundmedicine.com/medline/citation/19878731/Upregulation_of_stromal_cell_derived_factor_1alpha_in_collagen_vascular_diseases_associated_interstitial_pneumonias__CVDs_IPs__
L2 - https://linkinghub.elsevier.com/retrieve/pii/S1094-5539(09)00122-9
DB - PRIME
DP - Unbound Medicine
ER -