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Temperature-dependent threshold shear stress of red blood cell aggregation.
J Biomech. 2010 Feb 10; 43(3):546-50.JB

Abstract

Red blood cell (RBC) aggregation is becoming an important hemorheological parameter, which exhibits a unique temperature dependence. However, further investigation is still required for understanding the temperature-dependent characteristics of hemorheology that includes RBC aggregation. In the present study, blood samples were examined at 3, 10, 20, 30, and 37 degrees C. When the temperature decreases, the whole-blood and plasma viscosities increase, whereas the aggregation indices (AI, M, and b) yield contrary results. Since these contradictory results are known to arise from an increase in the plasma viscosity as the temperature decreases, aggregation indices that were corrected for plasma viscosity were examined. The corrected indices showed mixed results with the variation of the temperature. However, the threshold shear rate and the threshold shear stress increased as the temperature decreased, which is a trend that agrees with that of the blood viscosity. As the temperature decreases, RBC aggregates become more resistant to hydrodynamic dispersion and the corresponding threshold shear stress increases as does the blood viscosity. Therefore, the threshold shear stress may help to better clarify the mechanics of RBC aggregation under both physiological and pathological conditions.

Authors+Show Affiliations

School of Mechanical Engineering, Korea University, Anam-dong Seongbuk-gu, Seoul 136-713, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19878949

Citation

Lim, Hyun-Jung, et al. "Temperature-dependent Threshold Shear Stress of Red Blood Cell Aggregation." Journal of Biomechanics, vol. 43, no. 3, 2010, pp. 546-50.
Lim HJ, Lee YJ, Nam JH, et al. Temperature-dependent threshold shear stress of red blood cell aggregation. J Biomech. 2010;43(3):546-50.
Lim, H. J., Lee, Y. J., Nam, J. H., Chung, S., & Shin, S. (2010). Temperature-dependent threshold shear stress of red blood cell aggregation. Journal of Biomechanics, 43(3), 546-50. https://doi.org/10.1016/j.jbiomech.2009.09.031
Lim HJ, et al. Temperature-dependent Threshold Shear Stress of Red Blood Cell Aggregation. J Biomech. 2010 Feb 10;43(3):546-50. PubMed PMID: 19878949.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Temperature-dependent threshold shear stress of red blood cell aggregation. AU - Lim,Hyun-Jung, AU - Lee,Yong-Jin, AU - Nam,Jeong-Hun, AU - Chung,Seok, AU - Shin,Sehyun, Y1 - 2009/10/29/ PY - 2009/05/25/received PY - 2009/08/05/revised PY - 2009/09/06/accepted PY - 2009/11/3/entrez PY - 2009/11/3/pubmed PY - 2010/4/16/medline SP - 546 EP - 50 JF - Journal of biomechanics JO - J Biomech VL - 43 IS - 3 N2 - Red blood cell (RBC) aggregation is becoming an important hemorheological parameter, which exhibits a unique temperature dependence. However, further investigation is still required for understanding the temperature-dependent characteristics of hemorheology that includes RBC aggregation. In the present study, blood samples were examined at 3, 10, 20, 30, and 37 degrees C. When the temperature decreases, the whole-blood and plasma viscosities increase, whereas the aggregation indices (AI, M, and b) yield contrary results. Since these contradictory results are known to arise from an increase in the plasma viscosity as the temperature decreases, aggregation indices that were corrected for plasma viscosity were examined. The corrected indices showed mixed results with the variation of the temperature. However, the threshold shear rate and the threshold shear stress increased as the temperature decreased, which is a trend that agrees with that of the blood viscosity. As the temperature decreases, RBC aggregates become more resistant to hydrodynamic dispersion and the corresponding threshold shear stress increases as does the blood viscosity. Therefore, the threshold shear stress may help to better clarify the mechanics of RBC aggregation under both physiological and pathological conditions. SN - 1873-2380 UR - https://www.unboundmedicine.com/medline/citation/19878949/Temperature_dependent_threshold_shear_stress_of_red_blood_cell_aggregation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9290(09)00550-8 DB - PRIME DP - Unbound Medicine ER -