Citation
Vesikari, Timo, et al. "RotaTeq, a Pentavalent Rotavirus Vaccine: Efficacy and Safety Among Infants in Europe." Vaccine, vol. 28, no. 2, 2009, pp. 345-51.
Vesikari T, Itzler R, Karvonen A, et al. RotaTeq, a pentavalent rotavirus vaccine: efficacy and safety among infants in Europe. Vaccine. 2009;28(2):345-51.
Vesikari, T., Itzler, R., Karvonen, A., Korhonen, T., Van Damme, P., Behre, U., Bona, G., Gothefors, L., Heaton, P. M., Dallas, M., & Goveia, M. G. (2009). RotaTeq, a pentavalent rotavirus vaccine: efficacy and safety among infants in Europe. Vaccine, 28(2), 345-51. https://doi.org/10.1016/j.vaccine.2009.10.041
Vesikari T, et al. RotaTeq, a Pentavalent Rotavirus Vaccine: Efficacy and Safety Among Infants in Europe. Vaccine. 2009 Dec 11;28(2):345-51. PubMed PMID: 19879226.
TY - JOUR
T1 - RotaTeq, a pentavalent rotavirus vaccine: efficacy and safety among infants in Europe.
AU - Vesikari,Timo,
AU - Itzler,Robbin,
AU - Karvonen,Aino,
AU - Korhonen,Tiina,
AU - Van Damme,Pierre,
AU - Behre,Ulrich,
AU - Bona,Gianni,
AU - Gothefors,Leif,
AU - Heaton,Penny M,
AU - Dallas,Michael,
AU - Goveia,Michelle G,
Y1 - 2009/10/29/
PY - 2009/06/29/received
PY - 2009/09/28/revised
PY - 2009/10/12/accepted
PY - 2009/11/3/entrez
PY - 2009/11/3/pubmed
PY - 2010/3/4/medline
SP - 345
EP - 51
JF - Vaccine
JO - Vaccine
VL - 28
IS - 2
N2 - A pentavalent human-bovine reassortant oral rotavirus vaccine, RotaTeq, was evaluated among nearly 70,000 infants in the Rotavirus Efficacy and Safety Trial (REST), of which 30,523 were from Europe. All infants were followed for serious adverse events as well as hospitalizations and emergency department (ED) visits. All adverse events, health care utilization, and RVGE regardless of severity were evaluated in the clinical efficacy cohort (N=2686) in Finland. RotaTeq was 98.3% (95% CI, 90.2-100%) and 68.0% (95% CI 60.3-74.4%) efficacious against severe rotavirus gastroenteritis (RVGE) and all RVGE due to any serotype for two rotavirus seasons post-vaccination. The combined rate of hospitalizations and ED visits due to RVGE of any serotype was reduced by 94.5% (95% CI, 91.3-96.8%) for up to 2 years after vaccination. There were no statistically significant differences between RotaTeq and placebo for any of the safety outcomes. In Europe, RotaTeq was highly efficacious and well tolerated.
SN - 1873-2518
UR - https://www.unboundmedicine.com/medline/citation/19879226/RotaTeq_a_pentavalent_rotavirus_vaccine:_efficacy_and_safety_among_infants_in_Europe_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(09)01571-0
DB - PRIME
DP - Unbound Medicine
ER -