Tags

Type your tag names separated by a space and hit enter

Aspirin intolerance: does desensitization alter the course of the disease?
Immunol Allergy Clin North Am. 2009 Nov; 29(4):669-75.IA

Abstract

Intolerance to acetylsalicylic acid and to other nonsteroidal anti-inflammatory drugs was first described in 1922. The clinical picture reveals a classic triad of symptoms: aspirin-induced bronchial asthma, aspirin sensitivity, and chronic rhinosinusitis with nasal polyps. In many cases, nasal polyps reveal as the first symptom of ASA sensitivity, indicating that the upper airways are predominantly involved in the pathogenetic process. The emphasis of this article is on the upper airways of ASA-intolerant patients. Imbalance of the eicosanoids leukotrienes and prostaglandins might be the pathophysiologic key to the disease. The patient's history and challenge tests with lysine-aspirin are the diagnostic tools of choice. Apart from surgical or pharmacologic therapy, ASA-desensitization therapy is the treatment of choice. Various desensitization protocols and routes of administration are discussed.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Klimek L
Center for Rhinology and Allergy, An den Quellen 10, D-65183 Wiesbaden, Germany. ludger.klimek@allergiezentrum.de
Pfaar O
No affiliation info available

MeSH

AnimalsAnti-Inflammatory Agents, Non-SteroidalAspirinBronchial Provocation TestsBronchoconstrictionCyclooxygenase 1Desensitization, ImmunologicDrug HypersensitivityGene Expression Regulation, EnzymologicHumansLeukotrienesNasal Polyps

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19879442

Citation

Klimek, L, and O Pfaar. "Aspirin Intolerance: Does Desensitization Alter the Course of the Disease?" Immunology and Allergy Clinics of North America, vol. 29, no. 4, 2009, pp. 669-75.
Klimek L, Pfaar O. Aspirin intolerance: does desensitization alter the course of the disease? Immunol Allergy Clin North Am. 2009;29(4):669-75.
Klimek, L., & Pfaar, O. (2009). Aspirin intolerance: does desensitization alter the course of the disease? Immunology and Allergy Clinics of North America, 29(4), 669-75. https://doi.org/10.1016/j.iac.2009.07.008
Klimek L, Pfaar O. Aspirin Intolerance: Does Desensitization Alter the Course of the Disease. Immunol Allergy Clin North Am. 2009;29(4):669-75. PubMed PMID: 19879442.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aspirin intolerance: does desensitization alter the course of the disease? AU - Klimek,L, AU - Pfaar,O, PY - 2009/11/3/entrez PY - 2009/11/3/pubmed PY - 2010/5/21/medline SP - 669 EP - 75 JF - Immunology and allergy clinics of North America JO - Immunol Allergy Clin North Am VL - 29 IS - 4 N2 - Intolerance to acetylsalicylic acid and to other nonsteroidal anti-inflammatory drugs was first described in 1922. The clinical picture reveals a classic triad of symptoms: aspirin-induced bronchial asthma, aspirin sensitivity, and chronic rhinosinusitis with nasal polyps. In many cases, nasal polyps reveal as the first symptom of ASA sensitivity, indicating that the upper airways are predominantly involved in the pathogenetic process. The emphasis of this article is on the upper airways of ASA-intolerant patients. Imbalance of the eicosanoids leukotrienes and prostaglandins might be the pathophysiologic key to the disease. The patient's history and challenge tests with lysine-aspirin are the diagnostic tools of choice. Apart from surgical or pharmacologic therapy, ASA-desensitization therapy is the treatment of choice. Various desensitization protocols and routes of administration are discussed. SN - 1557-8607 UR - https://www.unboundmedicine.com/medline/citation/19879442/Aspirin_intolerance:_does_desensitization_alter_the_course_of_the_disease DB - PRIME DP - Unbound Medicine ER -