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Effect of supplemental folic acid in pregnancy on childhood asthma: a prospective birth cohort study.
Am J Epidemiol. 2009 Dec 15; 170(12):1486-93.AJ

Abstract

This study aimed to investigate the effect of the timing, dose, and source of folate during pregnancy on childhood asthma by using data from an Australian prospective birth cohort study (n = 557) from 1998 to 2005. At 3.5 years and 5.5 years, 490 and 423 mothers and children participated in the study, respectively. Maternal folate intake from diet and supplements was assessed by food frequency questionnaire in early (<16 weeks) and late (30-34 weeks) pregnancy. The primary outcome was physician-diagnosed asthma, obtained by maternal-completed questionnaire. Asthma was reported in 11.6% of children at 3.5 years (n = 57) and in 11.8% of children at 5.5 years (n = 50). Folic acid taken in supplement form in late pregnancy was associated with an increased risk of childhood asthma at 3.5 years (relative risk (RR) = 1.26, 95% confidence interval (CI): 1.08, 1.43) and with persistent asthma (RR = 1.32, 95% CI: 1.03, 1.69). The effect sizes did not change with adjustment for potential confounders. The association was similar at 5.5 years but did not reach statistical significance (RR = 1.17, 95% CI: 0.96, 1.42) in univariable models. These findings on childhood asthma support previous observations that supplementation with folate in pregnancy leads to an allergic asthma phenotype in mice via epigenetic mechanisms and is associated with poorer respiratory outcomes in young children.

Authors+Show Affiliations

Research Centre for the Early Origins of Health and Disease, Robinson Institute, The University of Adelaide, Adelaide, South Australia, Australia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19880541

Citation

Whitrow, Melissa J., et al. "Effect of Supplemental Folic Acid in Pregnancy On Childhood Asthma: a Prospective Birth Cohort Study." American Journal of Epidemiology, vol. 170, no. 12, 2009, pp. 1486-93.
Whitrow MJ, Moore VM, Rumbold AR, et al. Effect of supplemental folic acid in pregnancy on childhood asthma: a prospective birth cohort study. Am J Epidemiol. 2009;170(12):1486-93.
Whitrow, M. J., Moore, V. M., Rumbold, A. R., & Davies, M. J. (2009). Effect of supplemental folic acid in pregnancy on childhood asthma: a prospective birth cohort study. American Journal of Epidemiology, 170(12), 1486-93. https://doi.org/10.1093/aje/kwp315
Whitrow MJ, et al. Effect of Supplemental Folic Acid in Pregnancy On Childhood Asthma: a Prospective Birth Cohort Study. Am J Epidemiol. 2009 Dec 15;170(12):1486-93. PubMed PMID: 19880541.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of supplemental folic acid in pregnancy on childhood asthma: a prospective birth cohort study. AU - Whitrow,Melissa J, AU - Moore,Vivienne M, AU - Rumbold,Alice R, AU - Davies,Michael J, Y1 - 2009/10/30/ PY - 2009/11/3/entrez PY - 2009/11/3/pubmed PY - 2010/2/4/medline SP - 1486 EP - 93 JF - American journal of epidemiology JO - Am J Epidemiol VL - 170 IS - 12 N2 - This study aimed to investigate the effect of the timing, dose, and source of folate during pregnancy on childhood asthma by using data from an Australian prospective birth cohort study (n = 557) from 1998 to 2005. At 3.5 years and 5.5 years, 490 and 423 mothers and children participated in the study, respectively. Maternal folate intake from diet and supplements was assessed by food frequency questionnaire in early (<16 weeks) and late (30-34 weeks) pregnancy. The primary outcome was physician-diagnosed asthma, obtained by maternal-completed questionnaire. Asthma was reported in 11.6% of children at 3.5 years (n = 57) and in 11.8% of children at 5.5 years (n = 50). Folic acid taken in supplement form in late pregnancy was associated with an increased risk of childhood asthma at 3.5 years (relative risk (RR) = 1.26, 95% confidence interval (CI): 1.08, 1.43) and with persistent asthma (RR = 1.32, 95% CI: 1.03, 1.69). The effect sizes did not change with adjustment for potential confounders. The association was similar at 5.5 years but did not reach statistical significance (RR = 1.17, 95% CI: 0.96, 1.42) in univariable models. These findings on childhood asthma support previous observations that supplementation with folate in pregnancy leads to an allergic asthma phenotype in mice via epigenetic mechanisms and is associated with poorer respiratory outcomes in young children. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/19880541/Effect_of_supplemental_folic_acid_in_pregnancy_on_childhood_asthma:_a_prospective_birth_cohort_study_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwp315 DB - PRIME DP - Unbound Medicine ER -