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Novel pathways for implantation and establishment and maintenance of pregnancy in mammals.
Mol Hum Reprod. 2010 Mar; 16(3):135-52.MH

Abstract

Uterine receptivity to implantation varies among species, and involves changes in expression of genes that are coordinate with attachment of trophectoderm to uterine lumenal and superficial glandular epithelia, modification of phenotype of uterine stromal cells, silencing of receptors for progesterone and estrogen, suppression of genes for immune recognition, alterations in membrane permeability to enhance conceptus-maternal exchange of factors, angiogenesis and vasculogenesis, increased vascularity of the endometrium, activation of genes for transport of nutrients into the uterine lumen, and enhanced signaling for pregnancy recognition. Differential expression of genes by uterine epithelial and stromal cells in response to progesterone, glucocorticoids, prostaglandins and interferons may influence uterine receptivity to implantation in mammals. Uterine receptivity to implantation is progesterone-dependent; however, implantation is preceded by loss of expression of receptors for progesterone (PGR) so that progesterone most likely acts via PGR-positive stromal cells throughout pregnancy. Endogenous retroviruses expressed by the uterus and/or blastocyst also affect implantation and placentation in various species. Understanding the roles of the variety of hormones, growth factors and endogenous retroviral proteins in uterine receptivity for implantation is essential to enhancing reproductive health and fertility in humans and domestic animals.

Authors+Show Affiliations

Departments of Animal Science, Texas A&M Health Sciences Center, College Station, TX 77843, USA. fbazer@cvm.tamu.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review

Language

eng

PubMed ID

19880575

Citation

Bazer, Fuller W., et al. "Novel Pathways for Implantation and Establishment and Maintenance of Pregnancy in Mammals." Molecular Human Reproduction, vol. 16, no. 3, 2010, pp. 135-52.
Bazer FW, Wu G, Spencer TE, et al. Novel pathways for implantation and establishment and maintenance of pregnancy in mammals. Mol Hum Reprod. 2010;16(3):135-52.
Bazer, F. W., Wu, G., Spencer, T. E., Johnson, G. A., Burghardt, R. C., & Bayless, K. (2010). Novel pathways for implantation and establishment and maintenance of pregnancy in mammals. Molecular Human Reproduction, 16(3), 135-52. https://doi.org/10.1093/molehr/gap095
Bazer FW, et al. Novel Pathways for Implantation and Establishment and Maintenance of Pregnancy in Mammals. Mol Hum Reprod. 2010;16(3):135-52. PubMed PMID: 19880575.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Novel pathways for implantation and establishment and maintenance of pregnancy in mammals. AU - Bazer,Fuller W, AU - Wu,Guoyao, AU - Spencer,Thomas E, AU - Johnson,Greg A, AU - Burghardt,Robert C, AU - Bayless,Kayla, Y1 - 2009/10/30/ PY - 2009/11/3/entrez PY - 2009/11/3/pubmed PY - 2010/4/28/medline SP - 135 EP - 52 JF - Molecular human reproduction JO - Mol. Hum. Reprod. VL - 16 IS - 3 N2 - Uterine receptivity to implantation varies among species, and involves changes in expression of genes that are coordinate with attachment of trophectoderm to uterine lumenal and superficial glandular epithelia, modification of phenotype of uterine stromal cells, silencing of receptors for progesterone and estrogen, suppression of genes for immune recognition, alterations in membrane permeability to enhance conceptus-maternal exchange of factors, angiogenesis and vasculogenesis, increased vascularity of the endometrium, activation of genes for transport of nutrients into the uterine lumen, and enhanced signaling for pregnancy recognition. Differential expression of genes by uterine epithelial and stromal cells in response to progesterone, glucocorticoids, prostaglandins and interferons may influence uterine receptivity to implantation in mammals. Uterine receptivity to implantation is progesterone-dependent; however, implantation is preceded by loss of expression of receptors for progesterone (PGR) so that progesterone most likely acts via PGR-positive stromal cells throughout pregnancy. Endogenous retroviruses expressed by the uterus and/or blastocyst also affect implantation and placentation in various species. Understanding the roles of the variety of hormones, growth factors and endogenous retroviral proteins in uterine receptivity for implantation is essential to enhancing reproductive health and fertility in humans and domestic animals. SN - 1460-2407 UR - https://www.unboundmedicine.com/medline/citation/19880575/Novel_pathways_for_implantation_and_establishment_and_maintenance_of_pregnancy_in_mammals_ L2 - https://academic.oup.com/molehr/article-lookup/doi/10.1093/molehr/gap095 DB - PRIME DP - Unbound Medicine ER -