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Effects of walnut consumption on endothelial function in type 2 diabetic subjects: a randomized controlled crossover trial.
Diabetes Care. 2010 Feb; 33(2):227-32.DC

Abstract

OBJECTIVE

To determine the effects of daily walnut consumption on endothelial function, cardiovascular biomarkers, and anthropometric measures in type 2 diabetic individuals.

RESEARCH DESIGN AND METHODS

This study was a randomized, controlled, single-blind, crossover trial. Twenty-four participants with type 2 diabetes (mean age 58 years; 14 women and 10 men) were randomly assigned to one of the two possible sequence permutations to receive an ad libitum diet enriched with 56 g (366 kcal) walnuts/day and an ad libitum diet without walnuts for 8 weeks. Subjects underwent endothelial function testing (measured as flow-mediated dilatation [FMD]) and assessment of cardiovascular biomarkers before and after each 8-week treatment phase. The primary outcome measure was the change in FMD after 8 weeks. Secondary outcome measures included changes in plasma lipids, A1C, fasting glucose, insulin sensitivity, and anthropometric measures.

RESULTS

Endothelial function significantly improved after consumption of a walnut-enriched ad libitum diet compared with that after consumption of an ad libitum diet without walnuts (2.2 +/- 1.7 vs. 1.2 +/- 1.6%; P = 0.04). The walnut-enriched diet increased fasting serum glucose and lowered serum total cholesterol and LDL cholesterol from baseline (10.0 +/- 20.5 mg/dl, P = 0.04; -9.7 +/- 14.5 mg/dl, P < 0.01; and -7.7 +/- 10 mg/dl, P < 0.01, respectively), although these changes were not significant compared with those for an ad libitum diet without walnuts. There were no significant changes in anthropometric measures, plasma A1C, and insulin sensitivity.

CONCLUSIONS

A walnut-enriched ad libitum diet improves endothelium-dependent vasodilatation in type 2 diabetic individuals, suggesting a potential reduction in overall cardiac risk.

Authors+Show Affiliations

Yale University School of Medicine, Derby, Connecticut, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19880586

Citation

Ma, Yingying, et al. "Effects of Walnut Consumption On Endothelial Function in Type 2 Diabetic Subjects: a Randomized Controlled Crossover Trial." Diabetes Care, vol. 33, no. 2, 2010, pp. 227-32.
Ma Y, Njike VY, Millet J, et al. Effects of walnut consumption on endothelial function in type 2 diabetic subjects: a randomized controlled crossover trial. Diabetes Care. 2010;33(2):227-32.
Ma, Y., Njike, V. Y., Millet, J., Dutta, S., Doughty, K., Treu, J. A., & Katz, D. L. (2010). Effects of walnut consumption on endothelial function in type 2 diabetic subjects: a randomized controlled crossover trial. Diabetes Care, 33(2), 227-32. https://doi.org/10.2337/dc09-1156
Ma Y, et al. Effects of Walnut Consumption On Endothelial Function in Type 2 Diabetic Subjects: a Randomized Controlled Crossover Trial. Diabetes Care. 2010;33(2):227-32. PubMed PMID: 19880586.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of walnut consumption on endothelial function in type 2 diabetic subjects: a randomized controlled crossover trial. AU - Ma,Yingying, AU - Njike,Valentine Yanchou, AU - Millet,John, AU - Dutta,Suparna, AU - Doughty,Kim, AU - Treu,Judith A, AU - Katz,David L, Y1 - 2009/10/30/ PY - 2009/11/3/entrez PY - 2009/11/3/pubmed PY - 2010/2/25/medline SP - 227 EP - 32 JF - Diabetes care JO - Diabetes Care VL - 33 IS - 2 N2 - OBJECTIVE: To determine the effects of daily walnut consumption on endothelial function, cardiovascular biomarkers, and anthropometric measures in type 2 diabetic individuals. RESEARCH DESIGN AND METHODS: This study was a randomized, controlled, single-blind, crossover trial. Twenty-four participants with type 2 diabetes (mean age 58 years; 14 women and 10 men) were randomly assigned to one of the two possible sequence permutations to receive an ad libitum diet enriched with 56 g (366 kcal) walnuts/day and an ad libitum diet without walnuts for 8 weeks. Subjects underwent endothelial function testing (measured as flow-mediated dilatation [FMD]) and assessment of cardiovascular biomarkers before and after each 8-week treatment phase. The primary outcome measure was the change in FMD after 8 weeks. Secondary outcome measures included changes in plasma lipids, A1C, fasting glucose, insulin sensitivity, and anthropometric measures. RESULTS: Endothelial function significantly improved after consumption of a walnut-enriched ad libitum diet compared with that after consumption of an ad libitum diet without walnuts (2.2 +/- 1.7 vs. 1.2 +/- 1.6%; P = 0.04). The walnut-enriched diet increased fasting serum glucose and lowered serum total cholesterol and LDL cholesterol from baseline (10.0 +/- 20.5 mg/dl, P = 0.04; -9.7 +/- 14.5 mg/dl, P < 0.01; and -7.7 +/- 10 mg/dl, P < 0.01, respectively), although these changes were not significant compared with those for an ad libitum diet without walnuts. There were no significant changes in anthropometric measures, plasma A1C, and insulin sensitivity. CONCLUSIONS: A walnut-enriched ad libitum diet improves endothelium-dependent vasodilatation in type 2 diabetic individuals, suggesting a potential reduction in overall cardiac risk. SN - 1935-5548 UR - https://www.unboundmedicine.com/medline/citation/19880586/Effects_of_walnut_consumption_on_endothelial_function_in_type_2_diabetic_subjects:_a_randomized_controlled_crossover_trial_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&amp;pmid=19880586 DB - PRIME DP - Unbound Medicine ER -