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Optimal growth and lower fat mass in preterm infants fed a protein-enriched postdischarge formula.
J Pediatr Gastroenterol Nutr. 2010 Feb; 50(2):200-7.JP

Abstract

BACKGROUND AND OBJECTIVES

Postdischarge formulas with extra energy and protein improve short-term growth but may also influence long-term body composition in an unwanted manner. Energy- and protein-enriched formulas with an increased protein-to-energy ratio improves gain of lean mass. The objective of the study was to investigate whether feeding a nutrient-enriched formula without extra energy after term, usually 3 to 4 weeks after discharge, would influence growth and body composition in infancy.

METHODS

In this randomized controlled trial preterm infants were fed fortified human milk or preterm formula until term. At term, 102 infants were randomized to a nutrient-enriched formula without extra energy or standard formula until 6 months corrected age. Twenty-six infants received unfortified human milk after term. At term and 6 months corrected age, anthropometry and a dual-energy x-ray absorptiometry (DEXA) scan were performed. Lean and fat mass (FM) were corrected for height.

RESULTS

There were no differences in growth or body size between the feeding groups. Infants fed the enriched formula gained less FM and had lower FM corrected for body size at 6 months corrected age than infants fed standard formula. Infants fed human milk had lower lean mass and higher FM corrected for body size at 6 months corrected age than formula-fed infants.

CONCLUSIONS

Feeding nutrient-enriched formula without extra energy after term does not change quantity of growth but does influence type of weight gain and body composition of preterm infants. Infants fed the nutrient-enriched formula had lower FM corrected for body size at 6 months corrected age than infants fed standard formula or human milk.

Authors+Show Affiliations

Department of Paediatrics/Neonatology, VU University Medical Centre, Amsterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19881394

Citation

Amesz, Eline M., et al. "Optimal Growth and Lower Fat Mass in Preterm Infants Fed a Protein-enriched Postdischarge Formula." Journal of Pediatric Gastroenterology and Nutrition, vol. 50, no. 2, 2010, pp. 200-7.
Amesz EM, Schaafsma A, Cranendonk A, et al. Optimal growth and lower fat mass in preterm infants fed a protein-enriched postdischarge formula. J Pediatr Gastroenterol Nutr. 2010;50(2):200-7.
Amesz, E. M., Schaafsma, A., Cranendonk, A., & Lafeber, H. N. (2010). Optimal growth and lower fat mass in preterm infants fed a protein-enriched postdischarge formula. Journal of Pediatric Gastroenterology and Nutrition, 50(2), 200-7. https://doi.org/10.1097/MPG.0b013e3181a8150d
Amesz EM, et al. Optimal Growth and Lower Fat Mass in Preterm Infants Fed a Protein-enriched Postdischarge Formula. J Pediatr Gastroenterol Nutr. 2010;50(2):200-7. PubMed PMID: 19881394.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Optimal growth and lower fat mass in preterm infants fed a protein-enriched postdischarge formula. AU - Amesz,Eline M, AU - Schaafsma,Anne, AU - Cranendonk,Anneke, AU - Lafeber,Harrie N, PY - 2009/11/3/entrez PY - 2009/11/3/pubmed PY - 2010/5/26/medline SP - 200 EP - 7 JF - Journal of pediatric gastroenterology and nutrition JO - J. Pediatr. Gastroenterol. Nutr. VL - 50 IS - 2 N2 - BACKGROUND AND OBJECTIVES: Postdischarge formulas with extra energy and protein improve short-term growth but may also influence long-term body composition in an unwanted manner. Energy- and protein-enriched formulas with an increased protein-to-energy ratio improves gain of lean mass. The objective of the study was to investigate whether feeding a nutrient-enriched formula without extra energy after term, usually 3 to 4 weeks after discharge, would influence growth and body composition in infancy. METHODS: In this randomized controlled trial preterm infants were fed fortified human milk or preterm formula until term. At term, 102 infants were randomized to a nutrient-enriched formula without extra energy or standard formula until 6 months corrected age. Twenty-six infants received unfortified human milk after term. At term and 6 months corrected age, anthropometry and a dual-energy x-ray absorptiometry (DEXA) scan were performed. Lean and fat mass (FM) were corrected for height. RESULTS: There were no differences in growth or body size between the feeding groups. Infants fed the enriched formula gained less FM and had lower FM corrected for body size at 6 months corrected age than infants fed standard formula. Infants fed human milk had lower lean mass and higher FM corrected for body size at 6 months corrected age than formula-fed infants. CONCLUSIONS: Feeding nutrient-enriched formula without extra energy after term does not change quantity of growth but does influence type of weight gain and body composition of preterm infants. Infants fed the nutrient-enriched formula had lower FM corrected for body size at 6 months corrected age than infants fed standard formula or human milk. SN - 1536-4801 UR - https://www.unboundmedicine.com/medline/citation/19881394/Optimal_growth_and_lower_fat_mass_in_preterm_infants_fed_a_protein_enriched_postdischarge_formula_ L2 - http://dx.doi.org/10.1097/MPG.0b013e3181a8150d DB - PRIME DP - Unbound Medicine ER -