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Heparin and insulin for hypertriglyceridemia-induced pancreatitis: case report.
ScientificWorldJournal. 2009 Nov 01; 9:1230-2.S

Abstract

Hypertriglyceridemia is the etiology of acute nonbiliary pancreatitis in up to 3% of patients. Along with the supportive treatment of acute pancreatitis, treating the precipitating cause is important as well. There have been reports where heparin and insulin have been used for acute reduction of triglycerides, although there are no established guidelines for efficacy of these modalities. Heparin and insulin decrease triglycerides by stimulating lipoprotein lipase activity, which degrades triglycerides into fatty acids and glycerol. We present a case where a 54-year-old male presented with hypertriglyceridemia-induced acute pancreatitis. The serum triglyceride level was 10,320 mg/dl (normal: 0-15 mg/dl) at the time of admission. We started the patient on intravenous insulin and heparin infusion, and within 24 h of induction of treatment, the levels decreased by 50% to 5407 mg/dl. Thus, heparin and insulin can be considered a safe treatment modality for rapidly reducing triglyceride levels.

Authors+Show Affiliations

Department of Internal Medicine, University of Missouri, Columbia and Harry S. Truman VA Hospital, Columbia, Missouri, USA. jaind@health.missouri.eduNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

19882092

Citation

Jain, Deepika, and John Zimmerschied. "Heparin and Insulin for Hypertriglyceridemia-induced Pancreatitis: Case Report." TheScientificWorldJournal, vol. 9, 2009, pp. 1230-2.
Jain D, Zimmerschied J. Heparin and insulin for hypertriglyceridemia-induced pancreatitis: case report. ScientificWorldJournal. 2009;9:1230-2.
Jain, D., & Zimmerschied, J. (2009). Heparin and insulin for hypertriglyceridemia-induced pancreatitis: case report. TheScientificWorldJournal, 9, 1230-2. https://doi.org/10.1100/tsw.2009.142
Jain D, Zimmerschied J. Heparin and Insulin for Hypertriglyceridemia-induced Pancreatitis: Case Report. ScientificWorldJournal. 2009 Nov 1;9:1230-2. PubMed PMID: 19882092.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Heparin and insulin for hypertriglyceridemia-induced pancreatitis: case report. AU - Jain,Deepika, AU - Zimmerschied,John, Y1 - 2009/11/01/ PY - 2009/11/3/entrez PY - 2009/11/3/pubmed PY - 2010/1/8/medline SP - 1230 EP - 2 JF - TheScientificWorldJournal JO - ScientificWorldJournal VL - 9 N2 - Hypertriglyceridemia is the etiology of acute nonbiliary pancreatitis in up to 3% of patients. Along with the supportive treatment of acute pancreatitis, treating the precipitating cause is important as well. There have been reports where heparin and insulin have been used for acute reduction of triglycerides, although there are no established guidelines for efficacy of these modalities. Heparin and insulin decrease triglycerides by stimulating lipoprotein lipase activity, which degrades triglycerides into fatty acids and glycerol. We present a case where a 54-year-old male presented with hypertriglyceridemia-induced acute pancreatitis. The serum triglyceride level was 10,320 mg/dl (normal: 0-15 mg/dl) at the time of admission. We started the patient on intravenous insulin and heparin infusion, and within 24 h of induction of treatment, the levels decreased by 50% to 5407 mg/dl. Thus, heparin and insulin can be considered a safe treatment modality for rapidly reducing triglyceride levels. SN - 1537-744X UR - https://www.unboundmedicine.com/medline/citation/19882092/Heparin_and_insulin_for_hypertriglyceridemia_induced_pancreatitis:_case_report_ L2 - https://dx.doi.org/10.1100/tsw.2009.142 DB - PRIME DP - Unbound Medicine ER -