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Protective effect of Solanum torvum on doxorubicin-induced nephrotoxicity in rats.
Food Chem Toxicol. 2010 Jan; 48(1):436-40.FC

Abstract

Nephrotoxicity is one of the important side effects of anthracycline antibiotics. The aim of the study was to determine the protective effect of Solanum torvum on doxorubicin-induced nephrotoxicity in rats using biochemical and histopathological approaches. Oxidative stress is the main factor in doxorubicin (DOX) induced nephrotoxicity. Wistar rats received either DOX (67.75 mg/kg, i.v, 2 days before sacrifice) or S. torvum (100mg/kg and 300 mg/kg, p.o.) prior to DOX treatment or S. torvum (100mg/kg and 300 mg/kg, p.o.) extract alone for 4 weeks. Nephrotoxicity was assessed by measuring the abnormal levels of serum creatinine and blood urea nitrogen (BUN). The anti-oxidant defence enzymes superoxide dismutase (SOD) and catalase (CAT) of kidney tissue were also measured at the end of the treatment schedule. Treatment with S. torvum (100mg/kg and 300 mg/kg) significantly (p<0.05) decreased the levels of creatinine and BUN and significantly (p<0.05) increased the anti-oxidant defence enzyme levels of SOD and CAT. Histopathological changes showed that DOX caused significant structural damages to kidneys like tubular necrosis, renal lesions and glomerular congestion which was reversed with S. torvum. The results suggest that S. torvum has the potential in preventing the nephrotoxicity induced by doxorubicin.

Authors+Show Affiliations

Department of Pharmacology, MGV's Pharmacy College, Panchavati, Nashik 422 003, Maharashtra, India. mm_nasik@yahoo.co.inNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19883716

Citation

Mohan, Mahalaxmi, et al. "Protective Effect of Solanum Torvum On Doxorubicin-induced Nephrotoxicity in Rats." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 48, no. 1, 2010, pp. 436-40.
Mohan M, Kamble S, Gadhi P, et al. Protective effect of Solanum torvum on doxorubicin-induced nephrotoxicity in rats. Food Chem Toxicol. 2010;48(1):436-40.
Mohan, M., Kamble, S., Gadhi, P., & Kasture, S. (2010). Protective effect of Solanum torvum on doxorubicin-induced nephrotoxicity in rats. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 48(1), 436-40. https://doi.org/10.1016/j.fct.2009.10.042
Mohan M, et al. Protective Effect of Solanum Torvum On Doxorubicin-induced Nephrotoxicity in Rats. Food Chem Toxicol. 2010;48(1):436-40. PubMed PMID: 19883716.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of Solanum torvum on doxorubicin-induced nephrotoxicity in rats. AU - Mohan,Mahalaxmi, AU - Kamble,Sarika, AU - Gadhi,Prakash, AU - Kasture,Sanjay, Y1 - 2009/10/31/ PY - 2009/07/01/received PY - 2009/10/22/revised PY - 2009/10/27/accepted PY - 2009/11/4/entrez PY - 2009/11/4/pubmed PY - 2010/4/16/medline SP - 436 EP - 40 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 48 IS - 1 N2 - Nephrotoxicity is one of the important side effects of anthracycline antibiotics. The aim of the study was to determine the protective effect of Solanum torvum on doxorubicin-induced nephrotoxicity in rats using biochemical and histopathological approaches. Oxidative stress is the main factor in doxorubicin (DOX) induced nephrotoxicity. Wistar rats received either DOX (67.75 mg/kg, i.v, 2 days before sacrifice) or S. torvum (100mg/kg and 300 mg/kg, p.o.) prior to DOX treatment or S. torvum (100mg/kg and 300 mg/kg, p.o.) extract alone for 4 weeks. Nephrotoxicity was assessed by measuring the abnormal levels of serum creatinine and blood urea nitrogen (BUN). The anti-oxidant defence enzymes superoxide dismutase (SOD) and catalase (CAT) of kidney tissue were also measured at the end of the treatment schedule. Treatment with S. torvum (100mg/kg and 300 mg/kg) significantly (p<0.05) decreased the levels of creatinine and BUN and significantly (p<0.05) increased the anti-oxidant defence enzyme levels of SOD and CAT. Histopathological changes showed that DOX caused significant structural damages to kidneys like tubular necrosis, renal lesions and glomerular congestion which was reversed with S. torvum. The results suggest that S. torvum has the potential in preventing the nephrotoxicity induced by doxorubicin. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/19883716/Protective_effect_of_Solanum_torvum_on_doxorubicin_induced_nephrotoxicity_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(09)00503-1 DB - PRIME DP - Unbound Medicine ER -