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Attenuation of cyclosporine A-induced testicular and spermatozoal damages associated with oxidative stress by ellagic acid.
Int Immunopharmacol. 2010 Feb; 10(2):177-82.II

Abstract

This study was conducted to investigate the possible protective effect of ellagic acid (EA) on cyclosporine A (CsA)-induced testicular and spermatozoal damages associated with oxidative stress in male rats. Forty adult male Sprague-Dawley rats were divided into 4 groups of 10 animals each. Control group was used as placebo. Cyclosporine group received CsA at the dose of 15 mg/kg/day. Ellagic acid group was treated with EA (10 mg/kg/day). Cyclosporine plus ellagic acid group received CsA+EA. Reproductive organs were weighed and epididymal sperm characteristics and histopathological structure of testes were examined along with malondialdehyde (MDA) and glutathione (GSH) levels, glutathione-peroxidase (GSH-Px) and catalase (CAT) activities in testicular tissue. CsA significantly decreased the weights of testes and ventral prostate, epididymal sperm concentration, motility, testicular tissue glutathione (GSH), glutathione-peroxidase (GSH-Px) and catalase (CAT), diameters of seminiferous tubules and germinal cell layer thickness, and it significantly increased malondialdehyde (MDA) level and abnormal sperm rates along with degeneration, necrosis, immature germ cells, congestion and atrophy in testicular tissue. However, the CsA plus EA treatment attenuated all the CsA-induced negative changes observed in the testicular tissue, sperm and oxidant/antioxidant parameters. In conclusion, CsA-induced oxidative stress leads to the structural and functional damages in the testicular tissue and sperm quality of rats, and also EA has a protective effect on these damages.

Authors+Show Affiliations

Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Firat University, 23119 Elaziğ, Turkey. gturk@firat.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19883798

Citation

Türk, Gaffari, et al. "Attenuation of Cyclosporine A-induced Testicular and Spermatozoal Damages Associated With Oxidative Stress By Ellagic Acid." International Immunopharmacology, vol. 10, no. 2, 2010, pp. 177-82.
Türk G, Sönmez M, Ceribaşi AO, et al. Attenuation of cyclosporine A-induced testicular and spermatozoal damages associated with oxidative stress by ellagic acid. Int Immunopharmacol. 2010;10(2):177-82.
Türk, G., Sönmez, M., Ceribaşi, A. O., Yüce, A., & Ateşşahin, A. (2010). Attenuation of cyclosporine A-induced testicular and spermatozoal damages associated with oxidative stress by ellagic acid. International Immunopharmacology, 10(2), 177-82. https://doi.org/10.1016/j.intimp.2009.10.013
Türk G, et al. Attenuation of Cyclosporine A-induced Testicular and Spermatozoal Damages Associated With Oxidative Stress By Ellagic Acid. Int Immunopharmacol. 2010;10(2):177-82. PubMed PMID: 19883798.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Attenuation of cyclosporine A-induced testicular and spermatozoal damages associated with oxidative stress by ellagic acid. AU - Türk,Gaffari, AU - Sönmez,Mustafa, AU - Ceribaşi,Ali Osman, AU - Yüce,Abdurrauf, AU - Ateşşahin,Ahmet, Y1 - 2009/10/31/ PY - 2009/07/02/received PY - 2009/09/02/revised PY - 2009/10/23/accepted PY - 2009/11/4/entrez PY - 2009/11/4/pubmed PY - 2010/4/21/medline SP - 177 EP - 82 JF - International immunopharmacology JO - Int Immunopharmacol VL - 10 IS - 2 N2 - This study was conducted to investigate the possible protective effect of ellagic acid (EA) on cyclosporine A (CsA)-induced testicular and spermatozoal damages associated with oxidative stress in male rats. Forty adult male Sprague-Dawley rats were divided into 4 groups of 10 animals each. Control group was used as placebo. Cyclosporine group received CsA at the dose of 15 mg/kg/day. Ellagic acid group was treated with EA (10 mg/kg/day). Cyclosporine plus ellagic acid group received CsA+EA. Reproductive organs were weighed and epididymal sperm characteristics and histopathological structure of testes were examined along with malondialdehyde (MDA) and glutathione (GSH) levels, glutathione-peroxidase (GSH-Px) and catalase (CAT) activities in testicular tissue. CsA significantly decreased the weights of testes and ventral prostate, epididymal sperm concentration, motility, testicular tissue glutathione (GSH), glutathione-peroxidase (GSH-Px) and catalase (CAT), diameters of seminiferous tubules and germinal cell layer thickness, and it significantly increased malondialdehyde (MDA) level and abnormal sperm rates along with degeneration, necrosis, immature germ cells, congestion and atrophy in testicular tissue. However, the CsA plus EA treatment attenuated all the CsA-induced negative changes observed in the testicular tissue, sperm and oxidant/antioxidant parameters. In conclusion, CsA-induced oxidative stress leads to the structural and functional damages in the testicular tissue and sperm quality of rats, and also EA has a protective effect on these damages. SN - 1878-1705 UR - https://www.unboundmedicine.com/medline/citation/19883798/Attenuation_of_cyclosporine_A_induced_testicular_and_spermatozoal_damages_associated_with_oxidative_stress_by_ellagic_acid_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1567-5769(09)00346-4 DB - PRIME DP - Unbound Medicine ER -