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Lipid profile in Portuguese obese children and adolescents: interaction of apolipoprotein E polymorphism with adiponectin levels.
Arch Pediatr Adolesc Med. 2009 Nov; 163(11):1030-6.AP

Abstract

OBJECTIVE

To evaluate how the lipid profile associates with apolipoprotein (apo) E gene polymorphism, plasma adiponectin level, and body mass index (BMI) z score in Portuguese youth.

DESIGN

Transversal cohort study.

SETTING

Hospital de São João and Hospital de Crianças Maria Pia, Porto, Portugal, between May 2006 and March 2007.

PARTICIPANTS

One hundred thirty-eight obese children and adolescents (62 boys; mean age, 10.8 years [range, 4-16 years]). Participants were grouped according to (1) apo E polymorphism: presence of the apo E alleles 2 or 4 in E2 (n = 11) and E4 (n = 31) carriers, respectively, or as E3/E3 (n = 94) (carriers of E2/E4 [n = 2] were excluded from apo E analysis because they carry both alleles) and (2) BMI z score: group 1, BMI z score less than 2 (n = 31); group 2, BMI z score of 2 or more and less than 2.5 (n = 65); and group 3, BMI z score of 2.5 or more (n = 42).

MAIN OUTCOME MEASURES

Lipid variable comparisons between apo E polymorphism and BMI z score groups and influence of BMI z score and adiponectin level, adjusted for apo E polymorphism, on total cholesterol to high-density lipoprotein cholesterol and apo A-I to apo B ratios.

RESULTS

E4 carriers presented with a worse lipid profile when compared with E2 and E3/E3 carriers. There was also a clear risk of worsening for the group with the highest BMI z score. Apolipoprotein E polymorphism, BMI z score, and adiponectin level were significantly associated with total cholesterol to high-density lipoprotein cholesterol (standardized beta coefficient = 0.283, 0.354, and -0.292, respectively; P < .001 for all) and apo A-I to apo B (standardized beta coefficient = -0.372, -0.284, and 0.327, respectively; P < .001 for all) ratios.

CONCLUSION

Our data suggest a more atherogenic lipid profile for some apo E genotypes and for increasing BMI z score, whereas adiponectin level seems to play a protective role.

Authors+Show Affiliations

Departamento de Bioquímica, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal. henriqueferrao@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19884594

Citation

Nascimento, Henrique, et al. "Lipid Profile in Portuguese Obese Children and Adolescents: Interaction of Apolipoprotein E Polymorphism With Adiponectin Levels." Archives of Pediatrics & Adolescent Medicine, vol. 163, no. 11, 2009, pp. 1030-6.
Nascimento H, Silva L, Lourenço P, et al. Lipid profile in Portuguese obese children and adolescents: interaction of apolipoprotein E polymorphism with adiponectin levels. Arch Pediatr Adolesc Med. 2009;163(11):1030-6.
Nascimento, H., Silva, L., Lourenço, P., Weinfurterová, R., Castro, E., Rego, C., Ferreira, H., Guerra, A., Quintanilha, A., Santos-Silva, A., & Belo, L. (2009). Lipid profile in Portuguese obese children and adolescents: interaction of apolipoprotein E polymorphism with adiponectin levels. Archives of Pediatrics & Adolescent Medicine, 163(11), 1030-6. https://doi.org/10.1001/archpediatrics.2009.190
Nascimento H, et al. Lipid Profile in Portuguese Obese Children and Adolescents: Interaction of Apolipoprotein E Polymorphism With Adiponectin Levels. Arch Pediatr Adolesc Med. 2009;163(11):1030-6. PubMed PMID: 19884594.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipid profile in Portuguese obese children and adolescents: interaction of apolipoprotein E polymorphism with adiponectin levels. AU - Nascimento,Henrique, AU - Silva,Letícia, AU - Lourenço,Pedro, AU - Weinfurterová,Radka, AU - Castro,Elisabeth, AU - Rego,Carla, AU - Ferreira,Helena, AU - Guerra,António, AU - Quintanilha,Alexandre, AU - Santos-Silva,Alice, AU - Belo,Luís, PY - 2009/11/4/entrez PY - 2009/11/4/pubmed PY - 2009/12/23/medline SP - 1030 EP - 6 JF - Archives of pediatrics & adolescent medicine JO - Arch Pediatr Adolesc Med VL - 163 IS - 11 N2 - OBJECTIVE: To evaluate how the lipid profile associates with apolipoprotein (apo) E gene polymorphism, plasma adiponectin level, and body mass index (BMI) z score in Portuguese youth. DESIGN: Transversal cohort study. SETTING: Hospital de São João and Hospital de Crianças Maria Pia, Porto, Portugal, between May 2006 and March 2007. PARTICIPANTS: One hundred thirty-eight obese children and adolescents (62 boys; mean age, 10.8 years [range, 4-16 years]). Participants were grouped according to (1) apo E polymorphism: presence of the apo E alleles 2 or 4 in E2 (n = 11) and E4 (n = 31) carriers, respectively, or as E3/E3 (n = 94) (carriers of E2/E4 [n = 2] were excluded from apo E analysis because they carry both alleles) and (2) BMI z score: group 1, BMI z score less than 2 (n = 31); group 2, BMI z score of 2 or more and less than 2.5 (n = 65); and group 3, BMI z score of 2.5 or more (n = 42). MAIN OUTCOME MEASURES: Lipid variable comparisons between apo E polymorphism and BMI z score groups and influence of BMI z score and adiponectin level, adjusted for apo E polymorphism, on total cholesterol to high-density lipoprotein cholesterol and apo A-I to apo B ratios. RESULTS: E4 carriers presented with a worse lipid profile when compared with E2 and E3/E3 carriers. There was also a clear risk of worsening for the group with the highest BMI z score. Apolipoprotein E polymorphism, BMI z score, and adiponectin level were significantly associated with total cholesterol to high-density lipoprotein cholesterol (standardized beta coefficient = 0.283, 0.354, and -0.292, respectively; P < .001 for all) and apo A-I to apo B (standardized beta coefficient = -0.372, -0.284, and 0.327, respectively; P < .001 for all) ratios. CONCLUSION: Our data suggest a more atherogenic lipid profile for some apo E genotypes and for increasing BMI z score, whereas adiponectin level seems to play a protective role. SN - 1538-3628 UR - https://www.unboundmedicine.com/medline/citation/19884594/Lipid_profile_in_Portuguese_obese_children_and_adolescents:_interaction_of_apolipoprotein_E_polymorphism_with_adiponectin_levels_ L2 - https://jamanetwork.com/journals/jamapediatrics/fullarticle/10.1001/archpediatrics.2009.190 DB - PRIME DP - Unbound Medicine ER -