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Pharmacokinetics of green tea catechins in extract and sustained-release preparations.
J Diet Suppl 2008; 5(3):248-63JD

Abstract

Catechins are a major constituent of green tea. For green tea to have cancer therapeutic benefit, catechin concentrations in the range of 100 nM are required continuously until apoptosis (programmed cell death) is induced. To prolong elevated plasma and interstitial concentrations of catechins, a sustained-release formulation of green tea extract was tested and compared to a commercial green tea extract (Tegreen97®). Sustained-release formulations are usually developed in the pharmaceutical industry to slowly deliver the compound over a period of time and increase the dosing interval. Plasma and interstitial fluid (ISF) pharmacokinetics of catechins were determined following an oral dose in the rat. The sustained-release formulation profile included multiple smaller peaks of total catechins in both plasma and ISF. Interstitial fluid profiles of green tea extract indicate that higher catechins concentration and longer duration in tissue than in blood may make a sustained-release form unnecessary.

Authors+Show Affiliations

Botanical Center In Vivo Core, Purdue University, Department of Foods and Nutrition, West Lafayette, IN 47907, USA. janle@purdue.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19885387

Citation

Janle, Elsa M., et al. "Pharmacokinetics of Green Tea Catechins in Extract and Sustained-release Preparations." Journal of Dietary Supplements, vol. 5, no. 3, 2008, pp. 248-63.
Janle EM, Morré DM, Morré DJ, et al. Pharmacokinetics of green tea catechins in extract and sustained-release preparations. J Diet Suppl. 2008;5(3):248-63.
Janle, E. M., Morré, D. M., Morré, D. J., Zhou, Q., & Zhu, Y. (2008). Pharmacokinetics of green tea catechins in extract and sustained-release preparations. Journal of Dietary Supplements, 5(3), pp. 248-63.
Janle EM, et al. Pharmacokinetics of Green Tea Catechins in Extract and Sustained-release Preparations. J Diet Suppl. 2008;5(3):248-63. PubMed PMID: 19885387.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacokinetics of green tea catechins in extract and sustained-release preparations. AU - Janle,Elsa M, AU - Morré,Dorothy M, AU - Morré,D James, AU - Zhou,Qin, AU - Zhu,Yongxin, PY - 2009/11/4/entrez PY - 2009/11/4/pubmed PY - 2013/9/13/medline KW - Green tea pharmacokinetics KW - sustained release SP - 248 EP - 63 JF - Journal of dietary supplements JO - J Diet Suppl VL - 5 IS - 3 N2 - Catechins are a major constituent of green tea. For green tea to have cancer therapeutic benefit, catechin concentrations in the range of 100 nM are required continuously until apoptosis (programmed cell death) is induced. To prolong elevated plasma and interstitial concentrations of catechins, a sustained-release formulation of green tea extract was tested and compared to a commercial green tea extract (Tegreen97®). Sustained-release formulations are usually developed in the pharmaceutical industry to slowly deliver the compound over a period of time and increase the dosing interval. Plasma and interstitial fluid (ISF) pharmacokinetics of catechins were determined following an oral dose in the rat. The sustained-release formulation profile included multiple smaller peaks of total catechins in both plasma and ISF. Interstitial fluid profiles of green tea extract indicate that higher catechins concentration and longer duration in tissue than in blood may make a sustained-release form unnecessary. SN - 1939-022X UR - https://www.unboundmedicine.com/medline/citation/19885387/Pharmacokinetics_of_green_tea_catechins_in_extract_and_sustained_release_preparations_ L2 - http://www.tandfonline.com/doi/full/10.1080/19390210802414279 DB - PRIME DP - Unbound Medicine ER -