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The natural history of chronic kidney disease revisited--a 72-month Mayo Health System Hypertension Clinic practice-based research network prospective report on end-stage renal disease and death rates in 100 high-risk chronic kidney disease patients: a call for circumspection.
Adv Perit Dial. 2009; 25:85-8.AP

Abstract

The natural history of chronic kidney disease (CKD), in general, remains conjectural. Current literature on rates of progression to end-stage renal disease (ESRD) as compared with mortality in CKD shows conflicts. A study of 27,998 patients in managed care reported a 5-year ESRD rate of 20% and a death rate of 50%. In 1666 patients in the Modification of Diet in Renal Disease study, a much higher ESRD rate of 60% after 88 months was reported (four times the death rate); among patients older than 65 years, the death rate approximated the ESRD rate. More than 20 million Americans have CKD [estimated glomerular filtration rate (eGFR) < 60 mL/min). Annually, approximately 100,000 new U.S. patients develop ESRD, accounting for a casual annual ESRD rate of only 0.5% among the U.S. CKD population. Similarly, this author's anecdotal experience suggests a more benign CKD outcome than is suggested by the two foregoing studies. A 72-month prospective report of an aging cohort of 100 CKD patients, high risk because they all experienced acute kidney injury at study entry, is presented. The finding of an approximately 18% ESRD rate and 13% death rate after 4 years contrasts sharply with the two studies cited earlier. Several factors--prospective as compared with retrospective analysis, varying patient age and other variables, managed care as compared with other care, and other unknown variables--play important roles in CKD outcome. This author agrees with researchers who recently emphasized the heterogeneity of the CKD population. Patient prognosis and management must be individualized.

Authors+Show Affiliations

College of Medicine, Mayo Clinic, Rochester, Minnesota, USA. onuigbo.macaulay@mayo.edu

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19886324

Citation

Onuigbo, Macaulay A C.. "The Natural History of Chronic Kidney Disease Revisited--a 72-month Mayo Health System Hypertension Clinic Practice-based Research Network Prospective Report On End-stage Renal Disease and Death Rates in 100 High-risk Chronic Kidney Disease Patients: a Call for Circumspection." Advances in Peritoneal Dialysis. Conference On Peritoneal Dialysis, vol. 25, 2009, pp. 85-8.
Onuigbo MA. The natural history of chronic kidney disease revisited--a 72-month Mayo Health System Hypertension Clinic practice-based research network prospective report on end-stage renal disease and death rates in 100 high-risk chronic kidney disease patients: a call for circumspection. Adv Perit Dial. 2009;25:85-8.
Onuigbo, M. A. (2009). The natural history of chronic kidney disease revisited--a 72-month Mayo Health System Hypertension Clinic practice-based research network prospective report on end-stage renal disease and death rates in 100 high-risk chronic kidney disease patients: a call for circumspection. Advances in Peritoneal Dialysis. Conference On Peritoneal Dialysis, 25, 85-8.
Onuigbo MA. The Natural History of Chronic Kidney Disease Revisited--a 72-month Mayo Health System Hypertension Clinic Practice-based Research Network Prospective Report On End-stage Renal Disease and Death Rates in 100 High-risk Chronic Kidney Disease Patients: a Call for Circumspection. Adv Perit Dial. 2009;25:85-8. PubMed PMID: 19886324.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The natural history of chronic kidney disease revisited--a 72-month Mayo Health System Hypertension Clinic practice-based research network prospective report on end-stage renal disease and death rates in 100 high-risk chronic kidney disease patients: a call for circumspection. A1 - Onuigbo,Macaulay A C, PY - 2009/11/6/entrez PY - 2009/11/6/pubmed PY - 2009/12/16/medline SP - 85 EP - 8 JF - Advances in peritoneal dialysis. Conference on Peritoneal Dialysis JO - Adv Perit Dial VL - 25 N2 - The natural history of chronic kidney disease (CKD), in general, remains conjectural. Current literature on rates of progression to end-stage renal disease (ESRD) as compared with mortality in CKD shows conflicts. A study of 27,998 patients in managed care reported a 5-year ESRD rate of 20% and a death rate of 50%. In 1666 patients in the Modification of Diet in Renal Disease study, a much higher ESRD rate of 60% after 88 months was reported (four times the death rate); among patients older than 65 years, the death rate approximated the ESRD rate. More than 20 million Americans have CKD [estimated glomerular filtration rate (eGFR) < 60 mL/min). Annually, approximately 100,000 new U.S. patients develop ESRD, accounting for a casual annual ESRD rate of only 0.5% among the U.S. CKD population. Similarly, this author's anecdotal experience suggests a more benign CKD outcome than is suggested by the two foregoing studies. A 72-month prospective report of an aging cohort of 100 CKD patients, high risk because they all experienced acute kidney injury at study entry, is presented. The finding of an approximately 18% ESRD rate and 13% death rate after 4 years contrasts sharply with the two studies cited earlier. Several factors--prospective as compared with retrospective analysis, varying patient age and other variables, managed care as compared with other care, and other unknown variables--play important roles in CKD outcome. This author agrees with researchers who recently emphasized the heterogeneity of the CKD population. Patient prognosis and management must be individualized. SN - 1197-8554 UR - https://www.unboundmedicine.com/medline/citation/19886324/The_natural_history_of_chronic_kidney_disease_revisited__a_72_month_Mayo_Health_System_Hypertension_Clinic_practice_based_research_network_prospective_report_on_end_stage_renal_disease_and_death_rates_in_100_high_risk_chronic_kidney_disease_patients:_a_call_for_circumspection_ L2 - http://www.diseaseinfosearch.org/result/3996 DB - PRIME DP - Unbound Medicine ER -