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Anti-CCR3 monoclonal antibody inhibits eosinophil infiltration in Angiostrongylus cantonensis-infected ICR mice.
Acta Trop. 2010 Mar; 113(3):209-13.AT

Abstract

ICR mice were each infected with 35 Angiostrongylus cantonensis larvae. One group of mice received an intraperitoneal injection of anti-CCR3 monoclonal antibody (mAb) (50 microg) at 10 days post-infection (dpi), while another similarly-treated group also received a booster injection (25 microg) at 12 dpi. All the mice were sacrificed at 14 dpi for pathological examination, enzyme-linked immunosorbent assay analysis and RNA extraction. The infiltration of eosinophils and the severity of eosinophilic meningitis were reduced in both the mAb-treated groups, relative to infected but untreated animals. The levels of CCL11 (eotaxin) in the peripheral circulation and the expression of the Th2-type cytokine interleukin-5 in the brains were significantly reduced. A. cantonensis infection is the major cause of eosinophilic meningoencephalitis in Taiwan, and the results of this study could be useful for the development of strategies to reduce the neurological damage caused by this infection.

Authors+Show Affiliations

Section of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19887061

Citation

Chuang, Chih-Cheng, et al. "Anti-CCR3 Monoclonal Antibody Inhibits Eosinophil Infiltration in Angiostrongylus Cantonensis-infected ICR Mice." Acta Tropica, vol. 113, no. 3, 2010, pp. 209-13.
Chuang CC, Su KE, Chen CW, et al. Anti-CCR3 monoclonal antibody inhibits eosinophil infiltration in Angiostrongylus cantonensis-infected ICR mice. Acta Trop. 2010;113(3):209-13.
Chuang, C. C., Su, K. E., Chen, C. W., Fan, C. K., Lin, F. K., Chen, Y. S., & Du, W. Y. (2010). Anti-CCR3 monoclonal antibody inhibits eosinophil infiltration in Angiostrongylus cantonensis-infected ICR mice. Acta Tropica, 113(3), 209-13. https://doi.org/10.1016/j.actatropica.2009.10.017
Chuang CC, et al. Anti-CCR3 Monoclonal Antibody Inhibits Eosinophil Infiltration in Angiostrongylus Cantonensis-infected ICR Mice. Acta Trop. 2010;113(3):209-13. PubMed PMID: 19887061.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-CCR3 monoclonal antibody inhibits eosinophil infiltration in Angiostrongylus cantonensis-infected ICR mice. AU - Chuang,Chih-Cheng, AU - Su,Kua-Eyre, AU - Chen,Chi-Wu, AU - Fan,Chia-Kwung, AU - Lin,Feng-Kuan, AU - Chen,Yu-Shen, AU - Du,Wen-Yuan, Y1 - 2009/11/01/ PY - 2009/04/06/received PY - 2009/10/14/revised PY - 2009/10/24/accepted PY - 2009/11/6/entrez PY - 2009/11/6/pubmed PY - 2010/4/22/medline SP - 209 EP - 13 JF - Acta tropica JO - Acta Trop VL - 113 IS - 3 N2 - ICR mice were each infected with 35 Angiostrongylus cantonensis larvae. One group of mice received an intraperitoneal injection of anti-CCR3 monoclonal antibody (mAb) (50 microg) at 10 days post-infection (dpi), while another similarly-treated group also received a booster injection (25 microg) at 12 dpi. All the mice were sacrificed at 14 dpi for pathological examination, enzyme-linked immunosorbent assay analysis and RNA extraction. The infiltration of eosinophils and the severity of eosinophilic meningitis were reduced in both the mAb-treated groups, relative to infected but untreated animals. The levels of CCL11 (eotaxin) in the peripheral circulation and the expression of the Th2-type cytokine interleukin-5 in the brains were significantly reduced. A. cantonensis infection is the major cause of eosinophilic meningoencephalitis in Taiwan, and the results of this study could be useful for the development of strategies to reduce the neurological damage caused by this infection. SN - 1873-6254 UR - https://www.unboundmedicine.com/medline/citation/19887061/Anti_CCR3_monoclonal_antibody_inhibits_eosinophil_infiltration_in_Angiostrongylus_cantonensis_infected_ICR_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0001-706X(09)00337-4 DB - PRIME DP - Unbound Medicine ER -