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microRNAs at the synapse.
Nat Rev Neurosci. 2009 Dec; 10(12):842-9.NR

Abstract

MicroRNAs (miRNAs) are emerging as key modulators of post-transcriptional gene regulation in a plethora of tissues, including the nervous system. Recent evidence points to a widespread role for neural miRNAs at various stages of synaptic development, including dendritogenesis, synapse formation and synapse maturation. Furthermore, studies from invertebrates indicate that miRNAs might contribute to the control of synapse function and plasticity in the adult. Key features of synapse-relevant miRNAs include their ability to regulate mRNA translation locally in the synaptodendritic compartment and the modulation of their expression and function by neuronal activity. The potentially huge impact of miRNA-based mechanisms on higher-order processing, memory and neuropsychiatric disorders in vertebrates is just starting to be recognized.

Authors+Show Affiliations

Interdisziplinäres Zentrum für Neurowissenschaften, SFB488 Junior Group, Universität Heidelberg, and Institut für Neuroanatomie, Universitätsklinikum Heidelberg, Heidelberg, Germany. schratt@ana.uni-heidelberg.de

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19888283

Citation

Schratt, Gerhard. "MicroRNAs at the Synapse." Nature Reviews. Neuroscience, vol. 10, no. 12, 2009, pp. 842-9.
Schratt G. MicroRNAs at the synapse. Nat Rev Neurosci. 2009;10(12):842-9.
Schratt, G. (2009). MicroRNAs at the synapse. Nature Reviews. Neuroscience, 10(12), 842-9. https://doi.org/10.1038/nrn2763
Schratt G. MicroRNAs at the Synapse. Nat Rev Neurosci. 2009;10(12):842-9. PubMed PMID: 19888283.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - microRNAs at the synapse. A1 - Schratt,Gerhard, Y1 - 2009/11/04/ PY - 2009/11/6/entrez PY - 2009/11/6/pubmed PY - 2009/12/16/medline SP - 842 EP - 9 JF - Nature reviews. Neuroscience JO - Nat. Rev. Neurosci. VL - 10 IS - 12 N2 - MicroRNAs (miRNAs) are emerging as key modulators of post-transcriptional gene regulation in a plethora of tissues, including the nervous system. Recent evidence points to a widespread role for neural miRNAs at various stages of synaptic development, including dendritogenesis, synapse formation and synapse maturation. Furthermore, studies from invertebrates indicate that miRNAs might contribute to the control of synapse function and plasticity in the adult. Key features of synapse-relevant miRNAs include their ability to regulate mRNA translation locally in the synaptodendritic compartment and the modulation of their expression and function by neuronal activity. The potentially huge impact of miRNA-based mechanisms on higher-order processing, memory and neuropsychiatric disorders in vertebrates is just starting to be recognized. SN - 1471-0048 UR - https://www.unboundmedicine.com/medline/citation/19888283/microRNAs_at_the_synapse_ L2 - http://dx.doi.org/10.1038/nrn2763 DB - PRIME DP - Unbound Medicine ER -