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LTA 252GG and GA genotypes are associated with diffuse-type noncardia gastric cancer risk in the Japanese population.
Helicobacter 2009; 14(6):571-9H

Abstract

BACKGROUND

There are limited numbers of reports on the association of lymphotoxin-alpha (LTA) genotypes with gastric cancer.

METHODS

A nested case-control study was carried out in the longitudinal cohort of atomic bomb survivors using stored sera before diagnosis (mean, 2.3 years) and blood cells. Enrolled were 287 cases with noncardia gastric cancer of diffuse and intestinal types and three controls per case selected from cohort members matched on age, gender, city, and time and type of serum storage and counter-matched on radiation dose.

RESULTS

LTA 252GG and GA genotypes were associated with the prevalence of Helicobacter pylori IgG seropositivity and higher antibody titer against H. pylori cytotoxin-associated gene A (CagA) protein in controls and they were an independent risk factor for noncardia gastric cancer of diffuse type (RR = 2.8 (95% CI: 1.3-6.3), p = .01, and RR = 2.7 (95% CI: 1.5-4.8), p < .001), but not for intestinal type, after adjusting for H. pylori IgG seropositivity, CagA antibody titers, chronic atrophic gastritis, smoking, and radiation dose. Cessation of smoking (RR = 0.4 (95% CI: 0.2-0.7), p < .001) and never smoking (RR = 0.4 (95% CI: 0.3-0.6), p < .001) were both protective for future noncardia gastric cancer. Radiation dose was associated with noncardia gastric cancer in subjects with both the LTA 252G-allele and never smoking/quit smoking histories (RR = 3.8 (95% CI: 1.7-5.9), p = .009).

CONCLUSION

The LTA 252 genotype is associated with noncardia gastric cancer of diffuse type in Japan and interacted with radiation dose.

Authors+Show Affiliations

International University of Health and Welfare Clinic, Ohtawara City, Tochigi, Japan. gensuzki@iuhw.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19889075

Citation

Suzuki, Gen, et al. "LTA 252GG and GA Genotypes Are Associated With Diffuse-type Noncardia Gastric Cancer Risk in the Japanese Population." Helicobacter, vol. 14, no. 6, 2009, pp. 571-9.
Suzuki G, Cullings H, Fujiwara S, et al. LTA 252GG and GA genotypes are associated with diffuse-type noncardia gastric cancer risk in the Japanese population. Helicobacter. 2009;14(6):571-9.
Suzuki, G., Cullings, H., Fujiwara, S., Matsuura, S., Kishi, T., Ohishi, W., ... Tahara, E. (2009). LTA 252GG and GA genotypes are associated with diffuse-type noncardia gastric cancer risk in the Japanese population. Helicobacter, 14(6), pp. 571-9. doi:10.1111/j.1523-5378.2009.00694.x.
Suzuki G, et al. LTA 252GG and GA Genotypes Are Associated With Diffuse-type Noncardia Gastric Cancer Risk in the Japanese Population. Helicobacter. 2009;14(6):571-9. PubMed PMID: 19889075.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - LTA 252GG and GA genotypes are associated with diffuse-type noncardia gastric cancer risk in the Japanese population. AU - Suzuki,Gen, AU - Cullings,Harry, AU - Fujiwara,Saeko, AU - Matsuura,Shinsuke, AU - Kishi,Takeshi, AU - Ohishi,Waka, AU - Akahoshi,Masazumi, AU - Hayashi,Tomonori, AU - Tahara,Eiichi, PY - 2009/11/6/entrez PY - 2009/11/6/pubmed PY - 2010/1/12/medline SP - 571 EP - 9 JF - Helicobacter JO - Helicobacter VL - 14 IS - 6 N2 - BACKGROUND: There are limited numbers of reports on the association of lymphotoxin-alpha (LTA) genotypes with gastric cancer. METHODS: A nested case-control study was carried out in the longitudinal cohort of atomic bomb survivors using stored sera before diagnosis (mean, 2.3 years) and blood cells. Enrolled were 287 cases with noncardia gastric cancer of diffuse and intestinal types and three controls per case selected from cohort members matched on age, gender, city, and time and type of serum storage and counter-matched on radiation dose. RESULTS: LTA 252GG and GA genotypes were associated with the prevalence of Helicobacter pylori IgG seropositivity and higher antibody titer against H. pylori cytotoxin-associated gene A (CagA) protein in controls and they were an independent risk factor for noncardia gastric cancer of diffuse type (RR = 2.8 (95% CI: 1.3-6.3), p = .01, and RR = 2.7 (95% CI: 1.5-4.8), p < .001), but not for intestinal type, after adjusting for H. pylori IgG seropositivity, CagA antibody titers, chronic atrophic gastritis, smoking, and radiation dose. Cessation of smoking (RR = 0.4 (95% CI: 0.2-0.7), p < .001) and never smoking (RR = 0.4 (95% CI: 0.3-0.6), p < .001) were both protective for future noncardia gastric cancer. Radiation dose was associated with noncardia gastric cancer in subjects with both the LTA 252G-allele and never smoking/quit smoking histories (RR = 3.8 (95% CI: 1.7-5.9), p = .009). CONCLUSION: The LTA 252 genotype is associated with noncardia gastric cancer of diffuse type in Japan and interacted with radiation dose. SN - 1523-5378 UR - https://www.unboundmedicine.com/medline/citation/19889075/LTA_252GG_and_GA_genotypes_are_associated_with_diffuse_type_noncardia_gastric_cancer_risk_in_the_Japanese_population_ L2 - https://doi.org/10.1111/j.1523-5378.2009.00694.x DB - PRIME DP - Unbound Medicine ER -