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Zinc status in chronic pancreatitis and its relationship with exocrine and endocrine insufficiency.
JOP. 2009 Nov 05; 10(6):651-6.JOP

Abstract

CONTEXT

A major role of the pancreas in zinc homeostasis has been suggested.

OBJECTIVE

To assess erythrocyte zinc status in chronic pancreatitis and to correlate it with pancreatic exocrine and endocrine insufficiency.

PATIENTS

One hundred and one patients with chronic pancreatitis (34 alcoholic chronic pancreatitis, 67 tropical chronic pancreatitis) were prospectively studied.

MAIN OUTCOME MEASURE

Disease characteristics and imaging features were recorded. Erythrocyte zinc was estimated by flame atomic absorption spectrophotometry. Exocrine insufficiency was assessed using polyclonal antibody ELISA for pancreatic stool elastase1. Endocrine insufficiency was assessed by serum glucose levels and insulin requirement.

RESULTS

Erythrocyte zinc was significantly lower in chronic pancreatitis patients than in the controls (26.5+/-9.5 microg/g Hb vs. 38.0+/-6.6 microg/g Hb; P<0.001), and in tropical chronic pancreatitis than in alcoholic chronic pancreatitis (25.0+/-10.4 microg/g Hb vs. 29.6+/-6.5 microg/g Hb, P=0.001). In chronic pancreatitis patients who had exocrine insufficiency, erythrocyte zinc positively correlated with stool elastase1 (r=0.587, P<0.001). Erythrocyte zinc levels were significantly lower in diabetic patients as compared to non-diabetics (P=0.036).

CONCLUSIONS

This study demonstrates zinc deficiency in chronic pancreatitis patients, and that zinc deficiency correlates with exocrine and endocrine insufficiency. Further studies may clarify the possible benefits of zinc supplementation in chronic pancreatitis.

Authors+Show Affiliations

Department of Gastroenterology, Amrita Institute of Medical Sciences. Cochin 682 041, Kerala, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19890187

Citation

Girish, Banavara Narasimhamurthy, et al. "Zinc Status in Chronic Pancreatitis and Its Relationship With Exocrine and Endocrine Insufficiency." JOP : Journal of the Pancreas, vol. 10, no. 6, 2009, pp. 651-6.
Girish BN, Rajesh G, Vaidyanathan K, et al. Zinc status in chronic pancreatitis and its relationship with exocrine and endocrine insufficiency. JOP. 2009;10(6):651-6.
Girish, B. N., Rajesh, G., Vaidyanathan, K., & Balakrishnan, V. (2009). Zinc status in chronic pancreatitis and its relationship with exocrine and endocrine insufficiency. JOP : Journal of the Pancreas, 10(6), 651-6.
Girish BN, et al. Zinc Status in Chronic Pancreatitis and Its Relationship With Exocrine and Endocrine Insufficiency. JOP. 2009 Nov 5;10(6):651-6. PubMed PMID: 19890187.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Zinc status in chronic pancreatitis and its relationship with exocrine and endocrine insufficiency. AU - Girish,Banavara Narasimhamurthy, AU - Rajesh,Gopalakrishna, AU - Vaidyanathan,Kannan, AU - Balakrishnan,Vallath, Y1 - 2009/11/05/ PY - 2009/11/6/entrez PY - 2009/11/6/pubmed PY - 2010/1/29/medline SP - 651 EP - 6 JF - JOP : Journal of the pancreas JO - JOP VL - 10 IS - 6 N2 - CONTEXT: A major role of the pancreas in zinc homeostasis has been suggested. OBJECTIVE: To assess erythrocyte zinc status in chronic pancreatitis and to correlate it with pancreatic exocrine and endocrine insufficiency. PATIENTS: One hundred and one patients with chronic pancreatitis (34 alcoholic chronic pancreatitis, 67 tropical chronic pancreatitis) were prospectively studied. MAIN OUTCOME MEASURE: Disease characteristics and imaging features were recorded. Erythrocyte zinc was estimated by flame atomic absorption spectrophotometry. Exocrine insufficiency was assessed using polyclonal antibody ELISA for pancreatic stool elastase1. Endocrine insufficiency was assessed by serum glucose levels and insulin requirement. RESULTS: Erythrocyte zinc was significantly lower in chronic pancreatitis patients than in the controls (26.5+/-9.5 microg/g Hb vs. 38.0+/-6.6 microg/g Hb; P<0.001), and in tropical chronic pancreatitis than in alcoholic chronic pancreatitis (25.0+/-10.4 microg/g Hb vs. 29.6+/-6.5 microg/g Hb, P=0.001). In chronic pancreatitis patients who had exocrine insufficiency, erythrocyte zinc positively correlated with stool elastase1 (r=0.587, P<0.001). Erythrocyte zinc levels were significantly lower in diabetic patients as compared to non-diabetics (P=0.036). CONCLUSIONS: This study demonstrates zinc deficiency in chronic pancreatitis patients, and that zinc deficiency correlates with exocrine and endocrine insufficiency. Further studies may clarify the possible benefits of zinc supplementation in chronic pancreatitis. SN - 1590-8577 UR - https://www.unboundmedicine.com/medline/citation/19890187/Zinc_status_in_chronic_pancreatitis_and_its_relationship_with_exocrine_and_endocrine_insufficiency_ L2 - http://www.diseaseinfosearch.org/result/9663 DB - PRIME DP - Unbound Medicine ER -