Tags

Type your tag names separated by a space and hit enter

Successful preimplantation genetic diagnosis of Hb Bart's hydrops fetalis in Singapore after fresh and frozen embryo replacement cycles.
Ann Acad Med Singap. 2009 Oct; 38(10):910-3.AA

Abstract

INTRODUCTION

We report the fi rst successful preimplantation genetic diagnosis (PGD) for Hb Bart's hydrops fetalis in Singapore, involving both fresh and frozen embryo replacement cycles.

CLINICAL PICTURE

Two couples who were carriers of the Southeast Asian type double gene deletion (--(SEA) deletion carriers) requested for PGD. Couple A had 2 previous affected pregnancies, while couple B have a child of unknown genotypic status.

TREATMENT

One PGD cycle was performed for each couple. The --(SEA) deletion was detected using a gap-PCR strategy. Couple A had 1 fresh-embryo replacement cycle while couple B underwent 2 frozen-embryo replacement cycles.

OUTCOME

Couple A achieved a twin pregnancy. Second trimester complications resulted in premature delivery, where 1 baby girl survived. Couple B achieved a singleton pregnancy resulting in delivery of a healthy baby boy. Genotype analysis of all babies confirmed the PGD results consistent with clinically unaffected status.

CONCLUSIONS

We have successfully performed PGD to avoid Hb Bart's hydrops fetalis syndrome.

Authors+Show Affiliations

Women's Health and Fertility Centre, Mount Elizabeth Medical Centre, Singapore.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19890585

Citation

Yap, Christine, et al. "Successful Preimplantation Genetic Diagnosis of Hb Bart's Hydrops Fetalis in Singapore After Fresh and Frozen Embryo Replacement Cycles." Annals of the Academy of Medicine, Singapore, vol. 38, no. 10, 2009, pp. 910-3.
Yap C, Wang W, Tan AS, et al. Successful preimplantation genetic diagnosis of Hb Bart's hydrops fetalis in Singapore after fresh and frozen embryo replacement cycles. Ann Acad Med Singap. 2009;38(10):910-3.
Yap, C., Wang, W., Tan, A. S., Tan, W. C., Lim, M. N., & Chong, S. S. (2009). Successful preimplantation genetic diagnosis of Hb Bart's hydrops fetalis in Singapore after fresh and frozen embryo replacement cycles. Annals of the Academy of Medicine, Singapore, 38(10), 910-3.
Yap C, et al. Successful Preimplantation Genetic Diagnosis of Hb Bart's Hydrops Fetalis in Singapore After Fresh and Frozen Embryo Replacement Cycles. Ann Acad Med Singap. 2009;38(10):910-3. PubMed PMID: 19890585.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Successful preimplantation genetic diagnosis of Hb Bart's hydrops fetalis in Singapore after fresh and frozen embryo replacement cycles. AU - Yap,Christine, AU - Wang,Wen, AU - Tan,Arnold S C, AU - Tan,Wei Chin, AU - Lim,Mui Nee, AU - Chong,Samuel S, PY - 2009/11/6/entrez PY - 2009/11/6/pubmed PY - 2010/2/2/medline SP - 910 EP - 3 JF - Annals of the Academy of Medicine, Singapore JO - Ann Acad Med Singap VL - 38 IS - 10 N2 - INTRODUCTION: We report the fi rst successful preimplantation genetic diagnosis (PGD) for Hb Bart's hydrops fetalis in Singapore, involving both fresh and frozen embryo replacement cycles. CLINICAL PICTURE: Two couples who were carriers of the Southeast Asian type double gene deletion (--(SEA) deletion carriers) requested for PGD. Couple A had 2 previous affected pregnancies, while couple B have a child of unknown genotypic status. TREATMENT: One PGD cycle was performed for each couple. The --(SEA) deletion was detected using a gap-PCR strategy. Couple A had 1 fresh-embryo replacement cycle while couple B underwent 2 frozen-embryo replacement cycles. OUTCOME: Couple A achieved a twin pregnancy. Second trimester complications resulted in premature delivery, where 1 baby girl survived. Couple B achieved a singleton pregnancy resulting in delivery of a healthy baby boy. Genotype analysis of all babies confirmed the PGD results consistent with clinically unaffected status. CONCLUSIONS: We have successfully performed PGD to avoid Hb Bart's hydrops fetalis syndrome. SN - 0304-4602 UR - https://www.unboundmedicine.com/medline/citation/19890585/Successful_preimplantation_genetic_diagnosis_of_Hb_Bart's_hydrops_fetalis_in_Singapore_after_fresh_and_frozen_embryo_replacement_cycles_ L2 - http://www.annals.edu.sg/pdf/38VolNo10Oct2009/V38N10p910.pdf DB - PRIME DP - Unbound Medicine ER -