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Opposite relationships between cannabis use and neurocognitive functioning in bipolar disorder and schizophrenia.
Psychol Med 2010; 40(8):1337-47PM

Abstract

BACKGROUND

Cannabis use is associated with altered neurocognitive functioning in severe mental disorders, but data are still inconclusive and there are no studies of bipolar disorder. The aim of this study was to investigate the association between cannabis use and neurocognition in bipolar disorder compared with schizophrenia in a naturalistic setting.

METHOD

A total of 133 patients with bipolar disorder and 140 patients with schizophrenia underwent neuropsychological assessments and clinical characterization including measures of substance use. Relationships between cannabis users and neurocognitive function were explored in the two diagnostic groups. Possible interactions between diagnosis and cannabis use were investigated, and findings were controlled for possible confounders.

RESULTS

In bipolar disorder subjects, cannabis use was associated with better neurocognitive function, but the opposite was the case for the schizophrenia subjects. There was a statistically significant interaction effect of diagnosis and cannabis use on focused attention (p=0.019), executive functioning (verbal fluency--set shifting) (p=0.009), logical memory-learning (p=0.007) and on logical memory-recall (p=0.004). These differences in neurocognitive function could not be explained by putative confounders.

CONCLUSIONS

The findings suggest that cannabis use may be related to improved neurocognition in bipolar disorder and compromised neurocognition in schizophrenia. The results need to be replicated in independent samples, and may suggest different underlying disease mechanisms in the two disorders.

Authors+Show Affiliations

Institute of Psychiatry, University of Oslo, N-0318 Oslo, Norway.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19891810

Citation

Ringen, P A., et al. "Opposite Relationships Between Cannabis Use and Neurocognitive Functioning in Bipolar Disorder and Schizophrenia." Psychological Medicine, vol. 40, no. 8, 2010, pp. 1337-47.
Ringen PA, Vaskinn A, Sundet K, et al. Opposite relationships between cannabis use and neurocognitive functioning in bipolar disorder and schizophrenia. Psychol Med. 2010;40(8):1337-47.
Ringen, P. A., Vaskinn, A., Sundet, K., Engh, J. A., Jónsdóttir, H., Simonsen, C., ... Andreassen, O. A. (2010). Opposite relationships between cannabis use and neurocognitive functioning in bipolar disorder and schizophrenia. Psychological Medicine, 40(8), pp. 1337-47. doi:10.1017/S0033291709991620.
Ringen PA, et al. Opposite Relationships Between Cannabis Use and Neurocognitive Functioning in Bipolar Disorder and Schizophrenia. Psychol Med. 2010;40(8):1337-47. PubMed PMID: 19891810.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Opposite relationships between cannabis use and neurocognitive functioning in bipolar disorder and schizophrenia. AU - Ringen,P A, AU - Vaskinn,A, AU - Sundet,K, AU - Engh,J A, AU - Jónsdóttir,H, AU - Simonsen,C, AU - Friis,S, AU - Opjordsmoen,S, AU - Melle,I, AU - Andreassen,O A, Y1 - 2009/11/06/ PY - 2009/11/7/entrez PY - 2009/11/7/pubmed PY - 2010/10/15/medline SP - 1337 EP - 47 JF - Psychological medicine JO - Psychol Med VL - 40 IS - 8 N2 - BACKGROUND: Cannabis use is associated with altered neurocognitive functioning in severe mental disorders, but data are still inconclusive and there are no studies of bipolar disorder. The aim of this study was to investigate the association between cannabis use and neurocognition in bipolar disorder compared with schizophrenia in a naturalistic setting. METHOD: A total of 133 patients with bipolar disorder and 140 patients with schizophrenia underwent neuropsychological assessments and clinical characterization including measures of substance use. Relationships between cannabis users and neurocognitive function were explored in the two diagnostic groups. Possible interactions between diagnosis and cannabis use were investigated, and findings were controlled for possible confounders. RESULTS: In bipolar disorder subjects, cannabis use was associated with better neurocognitive function, but the opposite was the case for the schizophrenia subjects. There was a statistically significant interaction effect of diagnosis and cannabis use on focused attention (p=0.019), executive functioning (verbal fluency--set shifting) (p=0.009), logical memory-learning (p=0.007) and on logical memory-recall (p=0.004). These differences in neurocognitive function could not be explained by putative confounders. CONCLUSIONS: The findings suggest that cannabis use may be related to improved neurocognition in bipolar disorder and compromised neurocognition in schizophrenia. The results need to be replicated in independent samples, and may suggest different underlying disease mechanisms in the two disorders. SN - 1469-8978 UR - https://www.unboundmedicine.com/medline/citation/19891810/full_citation/Opposite_relationships_between_cannabis_use_and_neurocognitive_functioning_in_bipolar_disorder_and_schizophrenia_ L2 - https://www.cambridge.org/core/product/identifier/S0033291709991620/type/journal_article DB - PRIME DP - Unbound Medicine ER -