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Effect of microinjection of histamine into the dorsal hippocampus on the orofacial formalin-induced pain in rats.
Eur J Pharmacol. 2010 Feb 10; 627(1-3):119-23.EJ

Abstract

Brain neuronal histamine, through its receptors, is involved in central pain perception. In the present study, the effect of microinjection of histamine, mepyramine (a histamine H(1) receptor antagonist) and ranitidine (a histamine H(2) receptor antagonist) into the dorsal hippocampus was investigated on a model of orofacial pain in rats. Orofacial pain was induced by subcutaneous injection of formalin (1%, 50 microl) in the upper lip in rats, and the time spent of face rubbing was measured in 3-min blocks for 45 min. Formalin induced a marked biphasic (first phase: 0-3 min; second phase: 15-33 min) pain. Intra-hippocampal injection of histamine at doses of 0.25, 0.5 microg attenuated the second phase, and at a dose of 1 microg, histamine suppressed both phases of pain. Intra-hippocampal injections of mepyramine and ranitidine at the same doses of 1, 2 and 4 microg produced no effects when used alone. Pretreatments with mepyramine and ranitidine at a same dose of 4 microg prevented histamine (1 microg)-induced antinociception. These results indicate that the activation of brain neuronal histamine at the levels of the hippocampus may produce antinociception. Hippocampal histamine-induced antinociception may be mediated thorough its H(1) and H(2) receptors.

Authors+Show Affiliations

Division of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19891965

Citation

Erfanparast, Amir, et al. "Effect of Microinjection of Histamine Into the Dorsal Hippocampus On the Orofacial Formalin-induced Pain in Rats." European Journal of Pharmacology, vol. 627, no. 1-3, 2010, pp. 119-23.
Erfanparast A, Tamaddonfard E, Farshid AA, et al. Effect of microinjection of histamine into the dorsal hippocampus on the orofacial formalin-induced pain in rats. Eur J Pharmacol. 2010;627(1-3):119-23.
Erfanparast, A., Tamaddonfard, E., Farshid, A. A., & Khalilzadeh, E. (2010). Effect of microinjection of histamine into the dorsal hippocampus on the orofacial formalin-induced pain in rats. European Journal of Pharmacology, 627(1-3), 119-23. https://doi.org/10.1016/j.ejphar.2009.10.063
Erfanparast A, et al. Effect of Microinjection of Histamine Into the Dorsal Hippocampus On the Orofacial Formalin-induced Pain in Rats. Eur J Pharmacol. 2010 Feb 10;627(1-3):119-23. PubMed PMID: 19891965.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of microinjection of histamine into the dorsal hippocampus on the orofacial formalin-induced pain in rats. AU - Erfanparast,Amir, AU - Tamaddonfard,Esmaeal, AU - Farshid,Amir Abbas, AU - Khalilzadeh,Emad, Y1 - 2009/11/03/ PY - 2009/07/27/received PY - 2009/10/09/revised PY - 2009/10/27/accepted PY - 2009/11/7/entrez PY - 2009/11/7/pubmed PY - 2010/4/7/medline SP - 119 EP - 23 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 627 IS - 1-3 N2 - Brain neuronal histamine, through its receptors, is involved in central pain perception. In the present study, the effect of microinjection of histamine, mepyramine (a histamine H(1) receptor antagonist) and ranitidine (a histamine H(2) receptor antagonist) into the dorsal hippocampus was investigated on a model of orofacial pain in rats. Orofacial pain was induced by subcutaneous injection of formalin (1%, 50 microl) in the upper lip in rats, and the time spent of face rubbing was measured in 3-min blocks for 45 min. Formalin induced a marked biphasic (first phase: 0-3 min; second phase: 15-33 min) pain. Intra-hippocampal injection of histamine at doses of 0.25, 0.5 microg attenuated the second phase, and at a dose of 1 microg, histamine suppressed both phases of pain. Intra-hippocampal injections of mepyramine and ranitidine at the same doses of 1, 2 and 4 microg produced no effects when used alone. Pretreatments with mepyramine and ranitidine at a same dose of 4 microg prevented histamine (1 microg)-induced antinociception. These results indicate that the activation of brain neuronal histamine at the levels of the hippocampus may produce antinociception. Hippocampal histamine-induced antinociception may be mediated thorough its H(1) and H(2) receptors. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/19891965/Effect_of_microinjection_of_histamine_into_the_dorsal_hippocampus_on_the_orofacial_formalin_induced_pain_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(09)00976-5 DB - PRIME DP - Unbound Medicine ER -