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Behavioral, thermal and neurochemical effects of acute and chronic 3,4-methylenedioxymethamphetamine ("Ecstasy") self-administration.
Behav Brain Res. 2010 Mar 05; 207(2):500-7.BB

Abstract

3,4-Methylenedioxymethamphetamine (MDMA) is a popular methamphetamine derivative associated with young adults and all-night dance parties. However, the enduring effects of MDMA at voluntary intake levels have not been extensively investigated. In this study, MDMA-influenced behaviors and core temperatures were assessed over the course of 20 daily MDMA self-administration sessions in rats. In vivo microdialysis techniques were used in a subsequent MDMA challenge test session to determine extracellular nucleus accumbens dopamine (NAcc DA) and serotonin (5-HT) levels in MDMA-experienced and naïve animals before and after a self-administered MDMA injection (3.0mg/kg, i.v.). During self-administration sessions, gradual and significant increases in MDMA intake and MDMA-stimulated locomotor activity were observed across sessions. Core temperature significantly decreased during initial MDMA sessions, but was unaltered by the last 10 sessions. In the MDMA challenge test, MDMA-naïve rats showed significantly higher NAcc 5-HT responses compared to MDMA-experienced rats, though MDMA experience did not affect the magnitude of NAcc DA response. The overall findings suggest that changes in MDMA-induced responses over the course of increasing levels of drug exposure may reflect the development of tolerance to a number of MDMA effects.

Authors+Show Affiliations

College of Pharmacy, Division of Pharmacology and Toxicology, University of Texas, Austin, TX 78712-0125, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19891989

Citation

Reveron, Maria Elena, et al. "Behavioral, Thermal and Neurochemical Effects of Acute and Chronic 3,4-methylenedioxymethamphetamine ("Ecstasy") Self-administration." Behavioural Brain Research, vol. 207, no. 2, 2010, pp. 500-7.
Reveron ME, Maier EY, Duvauchelle CL. Behavioral, thermal and neurochemical effects of acute and chronic 3,4-methylenedioxymethamphetamine ("Ecstasy") self-administration. Behav Brain Res. 2010;207(2):500-7.
Reveron, M. E., Maier, E. Y., & Duvauchelle, C. L. (2010). Behavioral, thermal and neurochemical effects of acute and chronic 3,4-methylenedioxymethamphetamine ("Ecstasy") self-administration. Behavioural Brain Research, 207(2), 500-7. https://doi.org/10.1016/j.bbr.2009.10.038
Reveron ME, Maier EY, Duvauchelle CL. Behavioral, Thermal and Neurochemical Effects of Acute and Chronic 3,4-methylenedioxymethamphetamine ("Ecstasy") Self-administration. Behav Brain Res. 2010 Mar 5;207(2):500-7. PubMed PMID: 19891989.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Behavioral, thermal and neurochemical effects of acute and chronic 3,4-methylenedioxymethamphetamine ("Ecstasy") self-administration. AU - Reveron,Maria Elena, AU - Maier,Esther Y, AU - Duvauchelle,Christine L, Y1 - 2009/11/03/ PY - 2009/03/20/received PY - 2009/10/23/revised PY - 2009/10/30/accepted PY - 2009/11/7/entrez PY - 2009/11/7/pubmed PY - 2010/4/14/medline SP - 500 EP - 7 JF - Behavioural brain research JO - Behav. Brain Res. VL - 207 IS - 2 N2 - 3,4-Methylenedioxymethamphetamine (MDMA) is a popular methamphetamine derivative associated with young adults and all-night dance parties. However, the enduring effects of MDMA at voluntary intake levels have not been extensively investigated. In this study, MDMA-influenced behaviors and core temperatures were assessed over the course of 20 daily MDMA self-administration sessions in rats. In vivo microdialysis techniques were used in a subsequent MDMA challenge test session to determine extracellular nucleus accumbens dopamine (NAcc DA) and serotonin (5-HT) levels in MDMA-experienced and naïve animals before and after a self-administered MDMA injection (3.0mg/kg, i.v.). During self-administration sessions, gradual and significant increases in MDMA intake and MDMA-stimulated locomotor activity were observed across sessions. Core temperature significantly decreased during initial MDMA sessions, but was unaltered by the last 10 sessions. In the MDMA challenge test, MDMA-naïve rats showed significantly higher NAcc 5-HT responses compared to MDMA-experienced rats, though MDMA experience did not affect the magnitude of NAcc DA response. The overall findings suggest that changes in MDMA-induced responses over the course of increasing levels of drug exposure may reflect the development of tolerance to a number of MDMA effects. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/19891989/Behavioral_thermal_and_neurochemical_effects_of_acute_and_chronic_34_methylenedioxymethamphetamine__"Ecstasy"__self_administration_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(09)00661-5 DB - PRIME DP - Unbound Medicine ER -