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Usefulness of triglycerides-to-high-density lipoprotein cholesterol ratio for predicting the first coronary event in men.
Am J Cardiol. 2009 Nov 15; 104(10):1393-7.AJ

Abstract

Overweight and obesity potentiate the development of cardiovascular risk factors but many doubts have arisen recently regarding their role in coronary events. We evaluated the predictive value of a surrogate maker of insulin resistance, the ratio of triglyceride (TG) to high-density lipoprotein (HDL), for the incidence of a first coronary event in men workers according to body mass index (BMI). We designed a case-control study of active subjects collected from a single factory through their annual health examination and medical reports. Case subjects included those with myocardial infarction, unstable angina pectoris, or subclinical myocardial ischemia detected through electrocardiographic abnormalities. The sample was constituted by 208 case and 2,080 control subjects (mean age 49.9 years, 49.6 to 50.2). General characteristics of case and control subjects were well matched. The TG/HDL ratio was significantly higher in case subjects compared to controls. Stratification of the sample revealed an increasing prevalence of case subjects and mean TG/HDL in each category of BMI. Multivariable analysis, adjusted by smoking, demonstrated that TG/HDL increased 50% the risk of a first coronary event (odds ratio [OR] 1.47, 95% confidence interval [CI] 1.26 to 1.71), whereas low-density lipoprotein cholesterol values indicated a more moderate increased risk (OR 1.01, 95% CI 1.005 to 1.012); metabolic syndrome (OR 1.76, 95% CI 0.94 to 3.30) and hypertension (OR 1.50, 95% CI 0.81 to 2.79) did not reach statistical significance. The TG/HDL ratio was associated with a first coronary event in all categories of BMI. In conclusion, the TG/HDL ratio has a high predictive value of a first coronary event regardless of BMI.

Authors+Show Affiliations

Department of Cardiology, Hospital Universitario de San Juan, Alicante, Spain. acordero@coma.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19892056

Citation

Cordero, Alberto, et al. "Usefulness of Triglycerides-to-high-density Lipoprotein Cholesterol Ratio for Predicting the First Coronary Event in Men." The American Journal of Cardiology, vol. 104, no. 10, 2009, pp. 1393-7.
Cordero A, Andrés E, Ordoñez B, et al. Usefulness of triglycerides-to-high-density lipoprotein cholesterol ratio for predicting the first coronary event in men. Am J Cardiol. 2009;104(10):1393-7.
Cordero, A., Andrés, E., Ordoñez, B., León, M., Laclaustra, M., Grima, A., Luengo, E., Moreno, J., Bes, M., Pascual, I., Civeira, F., Pocoví, M., Alegría, E., & Casasnovas, J. A. (2009). Usefulness of triglycerides-to-high-density lipoprotein cholesterol ratio for predicting the first coronary event in men. The American Journal of Cardiology, 104(10), 1393-7. https://doi.org/10.1016/j.amjcard.2009.07.008
Cordero A, et al. Usefulness of Triglycerides-to-high-density Lipoprotein Cholesterol Ratio for Predicting the First Coronary Event in Men. Am J Cardiol. 2009 Nov 15;104(10):1393-7. PubMed PMID: 19892056.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Usefulness of triglycerides-to-high-density lipoprotein cholesterol ratio for predicting the first coronary event in men. AU - Cordero,Alberto, AU - Andrés,Eva, AU - Ordoñez,Beatriz, AU - León,Montserrat, AU - Laclaustra,Martín, AU - Grima,Alberto, AU - Luengo,Emilio, AU - Moreno,José, AU - Bes,María, AU - Pascual,Isaac, AU - Civeira,Fernando, AU - Pocoví,Miguel, AU - Alegría,Eduardo, AU - Casasnovas,José A, AU - ,, PY - 2009/04/14/received PY - 2009/07/02/revised PY - 2009/07/02/accepted PY - 2009/11/7/entrez PY - 2009/11/7/pubmed PY - 2009/12/16/medline SP - 1393 EP - 7 JF - The American journal of cardiology JO - Am J Cardiol VL - 104 IS - 10 N2 - Overweight and obesity potentiate the development of cardiovascular risk factors but many doubts have arisen recently regarding their role in coronary events. We evaluated the predictive value of a surrogate maker of insulin resistance, the ratio of triglyceride (TG) to high-density lipoprotein (HDL), for the incidence of a first coronary event in men workers according to body mass index (BMI). We designed a case-control study of active subjects collected from a single factory through their annual health examination and medical reports. Case subjects included those with myocardial infarction, unstable angina pectoris, or subclinical myocardial ischemia detected through electrocardiographic abnormalities. The sample was constituted by 208 case and 2,080 control subjects (mean age 49.9 years, 49.6 to 50.2). General characteristics of case and control subjects were well matched. The TG/HDL ratio was significantly higher in case subjects compared to controls. Stratification of the sample revealed an increasing prevalence of case subjects and mean TG/HDL in each category of BMI. Multivariable analysis, adjusted by smoking, demonstrated that TG/HDL increased 50% the risk of a first coronary event (odds ratio [OR] 1.47, 95% confidence interval [CI] 1.26 to 1.71), whereas low-density lipoprotein cholesterol values indicated a more moderate increased risk (OR 1.01, 95% CI 1.005 to 1.012); metabolic syndrome (OR 1.76, 95% CI 0.94 to 3.30) and hypertension (OR 1.50, 95% CI 0.81 to 2.79) did not reach statistical significance. The TG/HDL ratio was associated with a first coronary event in all categories of BMI. In conclusion, the TG/HDL ratio has a high predictive value of a first coronary event regardless of BMI. SN - 1879-1913 UR - https://www.unboundmedicine.com/medline/citation/19892056/Usefulness_of_triglycerides_to_high_density_lipoprotein_cholesterol_ratio_for_predicting_the_first_coronary_event_in_men_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(09)01338-1 DB - PRIME DP - Unbound Medicine ER -