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Genetic risk factors for periodontitis in a Japanese population.
J Dent Res. 2009 Dec; 88(12):1137-41.JD

Abstract

Genetic variants at multiple loci have been shown to be associated with susceptibility to periodontitis. To better assess the genetic risk factors for periodontitis, we performed a case-control study in 319 Japanese individuals with periodontitis (172 aggressive and 147 chronic disease) and 303 race-matched healthy control individuals. Thirty-five functional gene polymorphisms that had been previously associated with immune responses were genotyped. For all gene polymorphisms tested, no significant differences were observed in the allele frequencies of persons with aggressive, chronic, and combined (aggressive and chronic) periodontitis, compared with control individuals. Multiple logistic regression analysis revealed a significant association of the vitamin D receptor +1056 T/C polymorphism with susceptibility to chronic periodontitis, after adjustment for age, gender, and smoking status (P = 0.002). These results suggest that none of the polymorphisms tested was strongly associated with periodontitis in a Japanese population. However, the vitamin D receptor +1056 polymorphism may be related to chronic periodontitis.

Authors+Show Affiliations

General Dentistry and Clinical Education Unit, Niigata University Medical and Dental Hospital, 2-5274 Gakkocho-dori, Chuo-ku, Niigata 951-8514, Japan. kotetsuo@dent.niigata-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19892918

Citation

Kobayashi, T, et al. "Genetic Risk Factors for Periodontitis in a Japanese Population." Journal of Dental Research, vol. 88, no. 12, 2009, pp. 1137-41.
Kobayashi T, Nagata T, Murakami S, et al. Genetic risk factors for periodontitis in a Japanese population. J Dent Res. 2009;88(12):1137-41.
Kobayashi, T., Nagata, T., Murakami, S., Takashiba, S., Kurihara, H., Izumi, Y., Numabe, Y., Watanabe, H., Kataoka, M., Nagai, A., Hayashi, J., Ohyama, H., Okamatsu, Y., Inagaki, Y., Tai, H., & Yoshie, H. (2009). Genetic risk factors for periodontitis in a Japanese population. Journal of Dental Research, 88(12), 1137-41. https://doi.org/10.1177/0022034509350037
Kobayashi T, et al. Genetic Risk Factors for Periodontitis in a Japanese Population. J Dent Res. 2009;88(12):1137-41. PubMed PMID: 19892918.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic risk factors for periodontitis in a Japanese population. AU - Kobayashi,T, AU - Nagata,T, AU - Murakami,S, AU - Takashiba,S, AU - Kurihara,H, AU - Izumi,Y, AU - Numabe,Y, AU - Watanabe,H, AU - Kataoka,M, AU - Nagai,A, AU - Hayashi,J, AU - Ohyama,H, AU - Okamatsu,Y, AU - Inagaki,Y, AU - Tai,H, AU - Yoshie,H, Y1 - 2009/11/05/ PY - 2009/11/7/entrez PY - 2009/11/7/pubmed PY - 2009/12/23/medline SP - 1137 EP - 41 JF - Journal of dental research JO - J Dent Res VL - 88 IS - 12 N2 - Genetic variants at multiple loci have been shown to be associated with susceptibility to periodontitis. To better assess the genetic risk factors for periodontitis, we performed a case-control study in 319 Japanese individuals with periodontitis (172 aggressive and 147 chronic disease) and 303 race-matched healthy control individuals. Thirty-five functional gene polymorphisms that had been previously associated with immune responses were genotyped. For all gene polymorphisms tested, no significant differences were observed in the allele frequencies of persons with aggressive, chronic, and combined (aggressive and chronic) periodontitis, compared with control individuals. Multiple logistic regression analysis revealed a significant association of the vitamin D receptor +1056 T/C polymorphism with susceptibility to chronic periodontitis, after adjustment for age, gender, and smoking status (P = 0.002). These results suggest that none of the polymorphisms tested was strongly associated with periodontitis in a Japanese population. However, the vitamin D receptor +1056 polymorphism may be related to chronic periodontitis. SN - 1544-0591 UR - https://www.unboundmedicine.com/medline/citation/19892918/Genetic_risk_factors_for_periodontitis_in_a_Japanese_population_ L2 - https://journals.sagepub.com/doi/10.1177/0022034509350037?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -