TY - JOUR T1 - Genetic risk factors for periodontitis in a Japanese population. AU - Kobayashi,T, AU - Nagata,T, AU - Murakami,S, AU - Takashiba,S, AU - Kurihara,H, AU - Izumi,Y, AU - Numabe,Y, AU - Watanabe,H, AU - Kataoka,M, AU - Nagai,A, AU - Hayashi,J, AU - Ohyama,H, AU - Okamatsu,Y, AU - Inagaki,Y, AU - Tai,H, AU - Yoshie,H, Y1 - 2009/11/05/ PY - 2009/11/7/entrez PY - 2009/11/7/pubmed PY - 2009/12/23/medline SP - 1137 EP - 41 JF - Journal of dental research JO - J Dent Res VL - 88 IS - 12 N2 - Genetic variants at multiple loci have been shown to be associated with susceptibility to periodontitis. To better assess the genetic risk factors for periodontitis, we performed a case-control study in 319 Japanese individuals with periodontitis (172 aggressive and 147 chronic disease) and 303 race-matched healthy control individuals. Thirty-five functional gene polymorphisms that had been previously associated with immune responses were genotyped. For all gene polymorphisms tested, no significant differences were observed in the allele frequencies of persons with aggressive, chronic, and combined (aggressive and chronic) periodontitis, compared with control individuals. Multiple logistic regression analysis revealed a significant association of the vitamin D receptor +1056 T/C polymorphism with susceptibility to chronic periodontitis, after adjustment for age, gender, and smoking status (P = 0.002). These results suggest that none of the polymorphisms tested was strongly associated with periodontitis in a Japanese population. However, the vitamin D receptor +1056 polymorphism may be related to chronic periodontitis. SN - 1544-0591 UR - https://www.unboundmedicine.com/medline/citation/19892918/Genetic_risk_factors_for_periodontitis_in_a_Japanese_population_ L2 - https://journals.sagepub.com/doi/10.1177/0022034509350037?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -