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Attenuation of cold restraint stress-induced gastric lesions by an olive leaf extract.
Gen Physiol Biophys. 2009; 28 Spec No:135-42.GP

Abstract

Olive leaf extract (OLE) possesses, among other, antioxidative properties, but whether it influences gastroprotection against stress-induced gastric lesions remains unknown. In this study we investigated the protective effect of OLE, a natural antioxidant, on gastric mucosal damage induced by cold restraint stress (CRS) in rats. Three different doses of commercial OLE EFLA((R)) 943 were applied intragastrically (i.g.) 30 min prior to stress induction. Macroscopic gastric lesions were evaluated and ulcer index (UI) was calculated. Histological evidence of gastric mucosal lesions was also obtained. Concentration of malondialdehyde (MDA) as an index of lipid peroxidation, and catalase (CAT) and superoxide dismutase (SOD) activities were determined in gastric mucosa. The effects of applied OLE on gastric mucosal lesions, lipid peroxidation and antioxidative enzymes activity were compared with effects of i.g. pretreatment of reference drug, ranitidine. CRS caused severe gastric lesions in all non-pretreated animals, and this finding was confirmed histologicaly. Pretreatment with OLE (40, 80 and 120 mg.kg(-1)), as well as with ranitidine (50 mg.kg(-1)), significantly (p < 0.001) attenuated stress-induced gastric lesions. Treatment with 80 mg.kg(-1) of OLE was the most effective in prevention of rise in gastric MDA level and decrease in CAT and SOD activity. The results obtained indicate that OLE possesses gastroprotective activity against CRS-induced gastric lesions in rats, possibly related to its antioxidative properties.

Authors+Show Affiliations

Biomedical Research, R&D Institute, Galenika a.d., Pasterova 2, 11000 Beograd, Serbia. ddekan@sezampro.rsNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19893091

Citation

Dekanski, Dragana, et al. "Attenuation of Cold Restraint Stress-induced Gastric Lesions By an Olive Leaf Extract." General Physiology and Biophysics, vol. 28 Spec No, 2009, pp. 135-42.
Dekanski D, Janićijević-Hudomal S, Ristić S, et al. Attenuation of cold restraint stress-induced gastric lesions by an olive leaf extract. Gen Physiol Biophys. 2009;28 Spec No:135-42.
Dekanski, D., Janićijević-Hudomal, S., Ristić, S., Radonjić, N. V., Petronijević, N. D., Piperski, V., & Mitrović, D. M. (2009). Attenuation of cold restraint stress-induced gastric lesions by an olive leaf extract. General Physiology and Biophysics, 28 Spec No, 135-42.
Dekanski D, et al. Attenuation of Cold Restraint Stress-induced Gastric Lesions By an Olive Leaf Extract. Gen Physiol Biophys. 2009;28 Spec No:135-42. PubMed PMID: 19893091.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Attenuation of cold restraint stress-induced gastric lesions by an olive leaf extract. AU - Dekanski,Dragana, AU - Janićijević-Hudomal,Snezana, AU - Ristić,Slavica, AU - Radonjić,Nevena V, AU - Petronijević,Natasa D, AU - Piperski,Vesna, AU - Mitrović,Dusan M, PY - 2009/11/7/entrez PY - 2009/1/1/pubmed PY - 2010/4/9/medline SP - 135 EP - 42 JF - General physiology and biophysics JO - Gen Physiol Biophys VL - 28 Spec No N2 - Olive leaf extract (OLE) possesses, among other, antioxidative properties, but whether it influences gastroprotection against stress-induced gastric lesions remains unknown. In this study we investigated the protective effect of OLE, a natural antioxidant, on gastric mucosal damage induced by cold restraint stress (CRS) in rats. Three different doses of commercial OLE EFLA((R)) 943 were applied intragastrically (i.g.) 30 min prior to stress induction. Macroscopic gastric lesions were evaluated and ulcer index (UI) was calculated. Histological evidence of gastric mucosal lesions was also obtained. Concentration of malondialdehyde (MDA) as an index of lipid peroxidation, and catalase (CAT) and superoxide dismutase (SOD) activities were determined in gastric mucosa. The effects of applied OLE on gastric mucosal lesions, lipid peroxidation and antioxidative enzymes activity were compared with effects of i.g. pretreatment of reference drug, ranitidine. CRS caused severe gastric lesions in all non-pretreated animals, and this finding was confirmed histologicaly. Pretreatment with OLE (40, 80 and 120 mg.kg(-1)), as well as with ranitidine (50 mg.kg(-1)), significantly (p < 0.001) attenuated stress-induced gastric lesions. Treatment with 80 mg.kg(-1) of OLE was the most effective in prevention of rise in gastric MDA level and decrease in CAT and SOD activity. The results obtained indicate that OLE possesses gastroprotective activity against CRS-induced gastric lesions in rats, possibly related to its antioxidative properties. SN - 0231-5882 UR - https://www.unboundmedicine.com/medline/citation/19893091/Attenuation_of_cold_restraint_stress_induced_gastric_lesions_by_an_olive_leaf_extract_ L2 - http://www.gpb.sav.sk/SI-2009/135.pdf DB - PRIME DP - Unbound Medicine ER -