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Pallidal deep brain stimulation in primary cervical dystonia with phasic type : clinical outcome and postoperative course.
J Korean Neurosurg Soc. 2009 Oct; 46(4):346-50.JK

Abstract

OBJECTIVE

The purpose of this study was to analyze in detail the relationship between outcome and time course of effect in medically refractory primary cervical dystonia (CD) with phasic type that was treated by bilateral globus pallidus internus (Gpi) deep brain stimulation (DBS).

METHODS

Six patients underwent bilateral implantation of DBS into the Gpi under the guide of microelectrode recording and were followed for 18.7 +/- 11.1 months. The mean duration of the CD was 5.8 +/- 3.4 years. The mean age at time of surgery was 54.2 +/- 10.2 years. Patients were evaluated with the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) and relief scale using patient self-reporting.

RESULTS

The TWSTRS total scores improved by 64.5%, 65.5%, 75.8%, and 76.0% at 3, 6, 12 months, and at the last available follow-up after surgery, respectively. Statistically significant improvements in the TWSTRS scores were observed 3 months after surgery (p = 0.028) with gradual improvement up to 12 months after surgery, thereafter, the improvement was sustained. However, there was no statistically significant difference between the scores at 3 and 12 months. Subjective improvement reported averaged 81.7 +/- 6.8% at last follow-up. Mild dysarthria, the most frequent adverse event, occurred in 3 patients.

CONCLUSIONS

Our results show that the bilateral Gpi-DBS can offer a significant therapeutic effect from 3 months postoperatively in patients with primary CD with phasic type, without significant side effects.

Authors+Show Affiliations

Department of Neurosurgery, Bongseng Memorial Hospital, Busan, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19893724

Citation

Jeong, Seong-Gyu, et al. "Pallidal Deep Brain Stimulation in Primary Cervical Dystonia With Phasic Type : Clinical Outcome and Postoperative Course." Journal of Korean Neurosurgical Society, vol. 46, no. 4, 2009, pp. 346-50.
Jeong SG, Lee MK, Kang JY, et al. Pallidal deep brain stimulation in primary cervical dystonia with phasic type : clinical outcome and postoperative course. J Korean Neurosurg Soc. 2009;46(4):346-50.
Jeong, S. G., Lee, M. K., Kang, J. Y., Jun, S. M., Lee, W. H., & Ghang, C. G. (2009). Pallidal deep brain stimulation in primary cervical dystonia with phasic type : clinical outcome and postoperative course. Journal of Korean Neurosurgical Society, 46(4), 346-50. https://doi.org/10.3340/jkns.2009.46.4.346
Jeong SG, et al. Pallidal Deep Brain Stimulation in Primary Cervical Dystonia With Phasic Type : Clinical Outcome and Postoperative Course. J Korean Neurosurg Soc. 2009;46(4):346-50. PubMed PMID: 19893724.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pallidal deep brain stimulation in primary cervical dystonia with phasic type : clinical outcome and postoperative course. AU - Jeong,Seong-Gyu, AU - Lee,Myung-Ki, AU - Kang,Ju-Young, AU - Jun,Sung-Man, AU - Lee,Won-Ho, AU - Ghang,Chang-Ghu, Y1 - 2009/10/31/ PY - 2009/06/16/received PY - 2009/09/09/revised PY - 2009/10/04/accepted PY - 2009/11/7/entrez PY - 2009/11/7/pubmed PY - 2009/11/7/medline KW - Cervical dystonia KW - Deep brain stimulation KW - Globus pallidus SP - 346 EP - 50 JF - Journal of Korean Neurosurgical Society JO - J Korean Neurosurg Soc VL - 46 IS - 4 N2 - OBJECTIVE: The purpose of this study was to analyze in detail the relationship between outcome and time course of effect in medically refractory primary cervical dystonia (CD) with phasic type that was treated by bilateral globus pallidus internus (Gpi) deep brain stimulation (DBS). METHODS: Six patients underwent bilateral implantation of DBS into the Gpi under the guide of microelectrode recording and were followed for 18.7 +/- 11.1 months. The mean duration of the CD was 5.8 +/- 3.4 years. The mean age at time of surgery was 54.2 +/- 10.2 years. Patients were evaluated with the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) and relief scale using patient self-reporting. RESULTS: The TWSTRS total scores improved by 64.5%, 65.5%, 75.8%, and 76.0% at 3, 6, 12 months, and at the last available follow-up after surgery, respectively. Statistically significant improvements in the TWSTRS scores were observed 3 months after surgery (p = 0.028) with gradual improvement up to 12 months after surgery, thereafter, the improvement was sustained. However, there was no statistically significant difference between the scores at 3 and 12 months. Subjective improvement reported averaged 81.7 +/- 6.8% at last follow-up. Mild dysarthria, the most frequent adverse event, occurred in 3 patients. CONCLUSIONS: Our results show that the bilateral Gpi-DBS can offer a significant therapeutic effect from 3 months postoperatively in patients with primary CD with phasic type, without significant side effects. SN - 1598-7876 UR - https://www.unboundmedicine.com/medline/citation/19893724/Pallidal_deep_brain_stimulation_in_primary_cervical_dystonia_with_phasic_type_:_clinical_outcome_and_postoperative_course_ L2 - http://jkns.or.kr/journal/view.php?doi=10.3340/jkns.2009.46.4.346 DB - PRIME DP - Unbound Medicine ER -
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