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Ascorbic acid prevents the dose-dependent inhibitory effects of polyphenols and phytates on nonheme-iron absorption.
Am J Clin Nutr 1991; 53(2):537-41AJ

Abstract

The effects of maize-bran phytate and of a polyphenol (tannic acid) on iron absorption from a white-bread meal were tested in 199 subjects. The phytate content was varied by adding different concentrations of phytate-free and ordinary maize bran. Iron absorption decreased progressively when maize bran containing increasing amounts of phytate phosphorous (phytate P) (from 10 to 58 mg) was given. The inhibitory effect was overcome by 30 mg ascorbic acid. The inhibitory effects of tannic acid (from 12 to 55 mg) were also dose dependent. Studies suggested that greater than or equal to 50 mg ascorbic acid would be required to overcome the inhibitory effects on iron absorption of any meal containing greater than 100 mg tannic acid. Our findings indicate that it may be possible to predict the bioavailability of iron in a diet if due account is taken of the relative content in the diet of the major promoters and inhibitors of iron absorption.

Authors+Show Affiliations

Department of Medicine, University of Witwatersrand, Johannesburg, South Africa.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1989423

Citation

Siegenberg, D, et al. "Ascorbic Acid Prevents the Dose-dependent Inhibitory Effects of Polyphenols and Phytates On Nonheme-iron Absorption." The American Journal of Clinical Nutrition, vol. 53, no. 2, 1991, pp. 537-41.
Siegenberg D, Baynes RD, Bothwell TH, et al. Ascorbic acid prevents the dose-dependent inhibitory effects of polyphenols and phytates on nonheme-iron absorption. Am J Clin Nutr. 1991;53(2):537-41.
Siegenberg, D., Baynes, R. D., Bothwell, T. H., Macfarlane, B. J., Lamparelli, R. D., Car, N. G., ... Mayet, F. (1991). Ascorbic acid prevents the dose-dependent inhibitory effects of polyphenols and phytates on nonheme-iron absorption. The American Journal of Clinical Nutrition, 53(2), pp. 537-41.
Siegenberg D, et al. Ascorbic Acid Prevents the Dose-dependent Inhibitory Effects of Polyphenols and Phytates On Nonheme-iron Absorption. Am J Clin Nutr. 1991;53(2):537-41. PubMed PMID: 1989423.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ascorbic acid prevents the dose-dependent inhibitory effects of polyphenols and phytates on nonheme-iron absorption. AU - Siegenberg,D, AU - Baynes,R D, AU - Bothwell,T H, AU - Macfarlane,B J, AU - Lamparelli,R D, AU - Car,N G, AU - MacPhail,P, AU - Schmidt,U, AU - Tal,A, AU - Mayet,F, PY - 1991/2/1/pubmed PY - 1991/2/1/medline PY - 1991/2/1/entrez SP - 537 EP - 41 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 53 IS - 2 N2 - The effects of maize-bran phytate and of a polyphenol (tannic acid) on iron absorption from a white-bread meal were tested in 199 subjects. The phytate content was varied by adding different concentrations of phytate-free and ordinary maize bran. Iron absorption decreased progressively when maize bran containing increasing amounts of phytate phosphorous (phytate P) (from 10 to 58 mg) was given. The inhibitory effect was overcome by 30 mg ascorbic acid. The inhibitory effects of tannic acid (from 12 to 55 mg) were also dose dependent. Studies suggested that greater than or equal to 50 mg ascorbic acid would be required to overcome the inhibitory effects on iron absorption of any meal containing greater than 100 mg tannic acid. Our findings indicate that it may be possible to predict the bioavailability of iron in a diet if due account is taken of the relative content in the diet of the major promoters and inhibitors of iron absorption. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/1989423/Ascorbic_acid_prevents_the_dose_dependent_inhibitory_effects_of_polyphenols_and_phytates_on_nonheme_iron_absorption_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/53.2.537 DB - PRIME DP - Unbound Medicine ER -