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[Comparative studies of anticoagulant and fibrinolytic effects of glyprolines Gly-Pro and Gly-Pro-Arg in conditions of immobilization stress].
Izv Akad Nauk Ser Biol. 2009 Sep-OctIA

Abstract

It has been shown that proline-containing peptides Gly-Pro and Gly-Pro-Arg in vitro had anticoagulant and nonenzymatic fibrinolytic activity. It was established that after intranasal introduction of these peptides to a rat, anticoagulant and fibrinolytic activity of enzymatic and nonenzymatic nature increased in the rat blood. The peptide protective effect against hypercoagulation induced by immobilization stress was found after repeated intranasal introduction of each peptide into the animal.

Authors

Grigor'eva ME
No affiliation info available
Liapina LA
No affiliation info available
Andreeva LA
No affiliation info available
Miasoedov NF
No affiliation info available

MeSH

Administration, IntranasalAnimalsAnticoagulantsBlood CoagulationBlood Coagulation DisordersDipeptidesFibrinolysisFibrinolytic AgentsMaleOligopeptidesRatsRestraint, PhysicalStress, PsychologicalTime Factors

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

rus

PubMed ID

19894599

Citation

Grigor'eva, M E., et al. "[Comparative Studies of Anticoagulant and Fibrinolytic Effects of Glyprolines Gly-Pro and Gly-Pro-Arg in Conditions of Immobilization Stress]." Izvestiia Akademii Nauk. Seriia Biologicheskaia, 2009, pp. 585-90.
Grigor'eva ME, Liapina LA, Andreeva LA, et al. [Comparative studies of anticoagulant and fibrinolytic effects of glyprolines Gly-Pro and Gly-Pro-Arg in conditions of immobilization stress]. Izv Akad Nauk Ser Biol. 2009.
Grigor'eva, M. E., Liapina, L. A., Andreeva, L. A., & Miasoedov, N. F. (2009). [Comparative studies of anticoagulant and fibrinolytic effects of glyprolines Gly-Pro and Gly-Pro-Arg in conditions of immobilization stress]. Izvestiia Akademii Nauk. Seriia Biologicheskaia, (5), 585-90.
Grigor'eva ME, et al. [Comparative Studies of Anticoagulant and Fibrinolytic Effects of Glyprolines Gly-Pro and Gly-Pro-Arg in Conditions of Immobilization Stress]. Izv Akad Nauk Ser Biol. 2009 Sep-Oct;(5)585-90. PubMed PMID: 19894599.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Comparative studies of anticoagulant and fibrinolytic effects of glyprolines Gly-Pro and Gly-Pro-Arg in conditions of immobilization stress]. AU - Grigor'eva,M E, AU - Liapina,L A, AU - Andreeva,L A, AU - Miasoedov,N F, PY - 2009/11/10/entrez PY - 2009/11/10/pubmed PY - 2010/3/20/medline SP - 585 EP - 90 JF - Izvestiia Akademii nauk. Seriia biologicheskaia JO - Izv Akad Nauk Ser Biol IS - 5 N2 - It has been shown that proline-containing peptides Gly-Pro and Gly-Pro-Arg in vitro had anticoagulant and nonenzymatic fibrinolytic activity. It was established that after intranasal introduction of these peptides to a rat, anticoagulant and fibrinolytic activity of enzymatic and nonenzymatic nature increased in the rat blood. The peptide protective effect against hypercoagulation induced by immobilization stress was found after repeated intranasal introduction of each peptide into the animal. SN - 1026-3470 UR - https://www.unboundmedicine.com/medline/citation/19894599/[Comparative_studies_of_anticoagulant_and_fibrinolytic_effects_of_glyprolines_Gly_Pro_and_Gly_Pro_Arg_in_conditions_of_immobilization_stress]_ L2 - https://medlineplus.gov/bloodthinners.html DB - PRIME DP - Unbound Medicine ER -