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Antibiotic use in infancy and symptoms of asthma, rhinoconjunctivitis, and eczema in children 6 and 7 years old: International Study of Asthma and Allergies in Childhood Phase III.
J Allergy Clin Immunol 2009; 124(5):982-9JA

Abstract

BACKGROUND

Phase III of the International Study of Asthma and Allergies in Childhood measured the global prevalence of symptoms of asthma, rhinoconjunctivitis, and eczema in children.

OBJECTIVE

To investigate the associations between the use of antibiotics in the first year of life and symptoms of asthma, rhinoconjunctivitis, and eczema in children 6 and 7 years old.

METHODS

Parents or guardians of children 6 and 7 years old completed written questionnaires on current symptoms and possible risk factors. Prevalence odds ratios (ORs) were estimated by using logistic regression.

RESULTS

A total of 193,412 children from 71 centers in 29 countries participated. Reported use of antibiotics in the first year of life was associated with an increased risk of current asthma symptoms (wheezing in the previous 12 months) with an OR (adjusted for sex, region of the world, language, and per capita gross national income) of 1.96 (95% CI, 1.85-2.07); this fell to 1.70 (1.60-1.80) when adjusted for other risk factors for asthma. Similar associations were observed for severe asthma symptoms (OR, 1.82; 95% CI, 1.67-1.98), and asthma ever (OR, 1.94; 95% CI, 1.83-2.06). Use of antibiotics in the first year of life was also associated, but less strongly, with increased risks of current symptoms of rhinoconjunctivitis (OR, 1.56; 95% CI, 1.46-1.66) and eczema (OR, 1.58; 95% CI, 1.33-1.51).

CONCLUSION

There is an association between antibiotic use in the first year of life and current symptoms of asthma, rhinoconjunctivitis, and eczema in children 6 and 7 years old. Further research is required to determine whether the observed associations are causal or are a result of confounding by indication or reverse causation.

Authors+Show Affiliations

Center for Public Health Research, Massey University, Wellington, New Zealand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19895986

Citation

Foliaki, Sunia, et al. "Antibiotic Use in Infancy and Symptoms of Asthma, Rhinoconjunctivitis, and Eczema in Children 6 and 7 Years Old: International Study of Asthma and Allergies in Childhood Phase III." The Journal of Allergy and Clinical Immunology, vol. 124, no. 5, 2009, pp. 982-9.
Foliaki S, Pearce N, Björkstén B, et al. Antibiotic use in infancy and symptoms of asthma, rhinoconjunctivitis, and eczema in children 6 and 7 years old: International Study of Asthma and Allergies in Childhood Phase III. J Allergy Clin Immunol. 2009;124(5):982-9.
Foliaki, S., Pearce, N., Björkstén, B., Mallol, J., Montefort, S., & von Mutius, E. (2009). Antibiotic use in infancy and symptoms of asthma, rhinoconjunctivitis, and eczema in children 6 and 7 years old: International Study of Asthma and Allergies in Childhood Phase III. The Journal of Allergy and Clinical Immunology, 124(5), pp. 982-9. doi:10.1016/j.jaci.2009.08.017.
Foliaki S, et al. Antibiotic Use in Infancy and Symptoms of Asthma, Rhinoconjunctivitis, and Eczema in Children 6 and 7 Years Old: International Study of Asthma and Allergies in Childhood Phase III. J Allergy Clin Immunol. 2009;124(5):982-9. PubMed PMID: 19895986.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibiotic use in infancy and symptoms of asthma, rhinoconjunctivitis, and eczema in children 6 and 7 years old: International Study of Asthma and Allergies in Childhood Phase III. AU - Foliaki,Sunia, AU - Pearce,Neil, AU - Björkstén,Bengt, AU - Mallol,Javier, AU - Montefort,Stephen, AU - von Mutius,Erika, AU - ,, PY - 2009/04/23/received PY - 2009/08/01/revised PY - 2009/08/06/accepted PY - 2009/11/10/entrez PY - 2009/11/10/pubmed PY - 2009/12/16/medline SP - 982 EP - 9 JF - The Journal of allergy and clinical immunology JO - J. Allergy Clin. Immunol. VL - 124 IS - 5 N2 - BACKGROUND: Phase III of the International Study of Asthma and Allergies in Childhood measured the global prevalence of symptoms of asthma, rhinoconjunctivitis, and eczema in children. OBJECTIVE: To investigate the associations between the use of antibiotics in the first year of life and symptoms of asthma, rhinoconjunctivitis, and eczema in children 6 and 7 years old. METHODS: Parents or guardians of children 6 and 7 years old completed written questionnaires on current symptoms and possible risk factors. Prevalence odds ratios (ORs) were estimated by using logistic regression. RESULTS: A total of 193,412 children from 71 centers in 29 countries participated. Reported use of antibiotics in the first year of life was associated with an increased risk of current asthma symptoms (wheezing in the previous 12 months) with an OR (adjusted for sex, region of the world, language, and per capita gross national income) of 1.96 (95% CI, 1.85-2.07); this fell to 1.70 (1.60-1.80) when adjusted for other risk factors for asthma. Similar associations were observed for severe asthma symptoms (OR, 1.82; 95% CI, 1.67-1.98), and asthma ever (OR, 1.94; 95% CI, 1.83-2.06). Use of antibiotics in the first year of life was also associated, but less strongly, with increased risks of current symptoms of rhinoconjunctivitis (OR, 1.56; 95% CI, 1.46-1.66) and eczema (OR, 1.58; 95% CI, 1.33-1.51). CONCLUSION: There is an association between antibiotic use in the first year of life and current symptoms of asthma, rhinoconjunctivitis, and eczema in children 6 and 7 years old. Further research is required to determine whether the observed associations are causal or are a result of confounding by indication or reverse causation. SN - 1097-6825 UR - https://www.unboundmedicine.com/medline/citation/19895986/Antibiotic_use_in_infancy_and_symptoms_of_asthma_rhinoconjunctivitis_and_eczema_in_children_6_and_7_years_old:_International_Study_of_Asthma_and_Allergies_in_Childhood_Phase_III_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-6749(09)01253-6 DB - PRIME DP - Unbound Medicine ER -