Tags

Type your tag names separated by a space and hit enter

Cortical neuritic plaques and hippocampal neurofibrillary tangles are related to dementia severity in elderly schizophrenia patients.
Schizophr Res 2010; 116(1):90-6SR

Abstract

Cognitive decline has been described in elderly patients with schizophrenia, but the underlying pathology remains unknown. Some studies report increases in plaques and neurofibrillary tangles, but there is no evidence for an increased risk for Alzheimer's disease (AD) in elderly schizophrenics. Models of a decreased cerebral reserve suggest that increases in AD-related neuropathology below the threshold for a neuropathological diagnosis could be related to dementia severity in elderly schizophrenia patients. We tested this hypothesis in 110 autopsy specimens of schizophrenia patients, without a neuropathological diagnosis of AD or other neurodegenerative disorders. Furthermore, we assessed the effects of apolipoprotein E (ApoE) status, a known genetic risk factor for AD. Measures of density of neuritic plaques were obtained in five cortical regions, and the degree of hippocampal neurofibrillary tangles was rated. Dementia severity was measured prior to postmortem using the Clinical Dementia Rating (CDR) scale. multivariate analyses of variance were conducted with the factors dementia severity, by ApoE4 carrier status. Hippocampal neurofibrillary tangles correlated with increased dementia severity (p<.05). Neuritic plaque density increased with greater dementia severity (p<.005), and ApoE4 carrier status (p<.005), and these differences were magnified by the ApoE4 carrier status (p<.01). Even below the threshold for a neuropathological diagnosis of AD, neuritic plaques and hippocampal neurofibrillary tangles are associated with dementia severity in schizophrenia patients, even more so in the presence of genetic risk factors, suggesting that a decreased cerebral reserve in elderly schizophrenics may increase susceptibility for dementia.

Authors+Show Affiliations

Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10128, USA. michael.rapp@charite.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

19896333

Citation

Rapp, Michael A., et al. "Cortical Neuritic Plaques and Hippocampal Neurofibrillary Tangles Are Related to Dementia Severity in Elderly Schizophrenia Patients." Schizophrenia Research, vol. 116, no. 1, 2010, pp. 90-6.
Rapp MA, Schnaider-Beeri M, Purohit DP, et al. Cortical neuritic plaques and hippocampal neurofibrillary tangles are related to dementia severity in elderly schizophrenia patients. Schizophr Res. 2010;116(1):90-6.
Rapp, M. A., Schnaider-Beeri, M., Purohit, D. P., Reichenberg, A., McGurk, S. R., Haroutunian, V., & Harvey, P. D. (2010). Cortical neuritic plaques and hippocampal neurofibrillary tangles are related to dementia severity in elderly schizophrenia patients. Schizophrenia Research, 116(1), pp. 90-6. doi:10.1016/j.schres.2009.10.013.
Rapp MA, et al. Cortical Neuritic Plaques and Hippocampal Neurofibrillary Tangles Are Related to Dementia Severity in Elderly Schizophrenia Patients. Schizophr Res. 2010;116(1):90-6. PubMed PMID: 19896333.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cortical neuritic plaques and hippocampal neurofibrillary tangles are related to dementia severity in elderly schizophrenia patients. AU - Rapp,Michael A, AU - Schnaider-Beeri,Michal, AU - Purohit,Dushyant P, AU - Reichenberg,Abraham, AU - McGurk,Susan R, AU - Haroutunian,Vahram, AU - Harvey,Philip D, PY - 2009/05/10/received PY - 2009/10/12/revised PY - 2009/10/17/accepted PY - 2009/11/10/entrez PY - 2009/11/10/pubmed PY - 2010/2/25/medline SP - 90 EP - 6 JF - Schizophrenia research JO - Schizophr. Res. VL - 116 IS - 1 N2 - Cognitive decline has been described in elderly patients with schizophrenia, but the underlying pathology remains unknown. Some studies report increases in plaques and neurofibrillary tangles, but there is no evidence for an increased risk for Alzheimer's disease (AD) in elderly schizophrenics. Models of a decreased cerebral reserve suggest that increases in AD-related neuropathology below the threshold for a neuropathological diagnosis could be related to dementia severity in elderly schizophrenia patients. We tested this hypothesis in 110 autopsy specimens of schizophrenia patients, without a neuropathological diagnosis of AD or other neurodegenerative disorders. Furthermore, we assessed the effects of apolipoprotein E (ApoE) status, a known genetic risk factor for AD. Measures of density of neuritic plaques were obtained in five cortical regions, and the degree of hippocampal neurofibrillary tangles was rated. Dementia severity was measured prior to postmortem using the Clinical Dementia Rating (CDR) scale. multivariate analyses of variance were conducted with the factors dementia severity, by ApoE4 carrier status. Hippocampal neurofibrillary tangles correlated with increased dementia severity (p<.05). Neuritic plaque density increased with greater dementia severity (p<.005), and ApoE4 carrier status (p<.005), and these differences were magnified by the ApoE4 carrier status (p<.01). Even below the threshold for a neuropathological diagnosis of AD, neuritic plaques and hippocampal neurofibrillary tangles are associated with dementia severity in schizophrenia patients, even more so in the presence of genetic risk factors, suggesting that a decreased cerebral reserve in elderly schizophrenics may increase susceptibility for dementia. SN - 1573-2509 UR - https://www.unboundmedicine.com/medline/citation/19896333/Cortical_neuritic_plaques_and_hippocampal_neurofibrillary_tangles_are_related_to_dementia_severity_in_elderly_schizophrenia_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0920-9964(09)00500-3 DB - PRIME DP - Unbound Medicine ER -