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Protective role of betulinic acid on TNF-alpha-induced cell adhesion molecules in vascular endothelial cells.
Biochem Biophys Res Commun. 2010 Jan 01; 391(1):96-101.BB

Abstract

Vascular inflammation is an important event in the development of vascular diseases such as tumor progression and atherosclerosis. In the present study, betulinic acid (BA) treatment was found to show potent inhibitory effect on vascular inflammation process by TNF-alpha in human umbilical vein endothelial cells (HUVEC). Pretreatment of HUVEC with BA was blocked TNF-alpha induced expression level of cell adhesion molecules such as intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), endothelial cell selectin (E-selectin) as well as gelatinase in TNF-alpha-activated HUVEC in a dose-dependent manner. When preincubated with BA, the adhesion of HL-60 cells to TNF-alpha-induced HUVEC was significantly decreased in a concentration-dependent manner. TNF-alpha-induced intracellular ROS was markedly decreased by pretreatment with BA. Furthermore, BA significantly inhibited the translocation and transcriptional activity of NF-kappaB increased by TNF-alpha. In conclusion, these results suggested a vascular protective role of BA via inhibition of ROS and NF-kappaB activation in HUVEC.

Authors+Show Affiliations

Professional Graduate School of Oriental Medicine, Wonkwang University, Shinyong-dong, Iksan, Jeonbuk 570-749, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19896462

Citation

Yoon, Jung Joo, et al. "Protective Role of Betulinic Acid On TNF-alpha-induced Cell Adhesion Molecules in Vascular Endothelial Cells." Biochemical and Biophysical Research Communications, vol. 391, no. 1, 2010, pp. 96-101.
Yoon JJ, Lee YJ, Kim JS, et al. Protective role of betulinic acid on TNF-alpha-induced cell adhesion molecules in vascular endothelial cells. Biochem Biophys Res Commun. 2010;391(1):96-101.
Yoon, J. J., Lee, Y. J., Kim, J. S., Kang, D. G., & Lee, H. S. (2010). Protective role of betulinic acid on TNF-alpha-induced cell adhesion molecules in vascular endothelial cells. Biochemical and Biophysical Research Communications, 391(1), 96-101. https://doi.org/10.1016/j.bbrc.2009.11.009
Yoon JJ, et al. Protective Role of Betulinic Acid On TNF-alpha-induced Cell Adhesion Molecules in Vascular Endothelial Cells. Biochem Biophys Res Commun. 2010 Jan 1;391(1):96-101. PubMed PMID: 19896462.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective role of betulinic acid on TNF-alpha-induced cell adhesion molecules in vascular endothelial cells. AU - Yoon,Jung Joo, AU - Lee,Yun Jung, AU - Kim,Jin Sook, AU - Kang,Dae Gill, AU - Lee,Ho Sub, Y1 - 2009/11/05/ PY - 2009/10/15/received PY - 2009/11/01/accepted PY - 2009/11/10/entrez PY - 2009/11/10/pubmed PY - 2010/3/17/medline SP - 96 EP - 101 JF - Biochemical and biophysical research communications JO - Biochem Biophys Res Commun VL - 391 IS - 1 N2 - Vascular inflammation is an important event in the development of vascular diseases such as tumor progression and atherosclerosis. In the present study, betulinic acid (BA) treatment was found to show potent inhibitory effect on vascular inflammation process by TNF-alpha in human umbilical vein endothelial cells (HUVEC). Pretreatment of HUVEC with BA was blocked TNF-alpha induced expression level of cell adhesion molecules such as intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), endothelial cell selectin (E-selectin) as well as gelatinase in TNF-alpha-activated HUVEC in a dose-dependent manner. When preincubated with BA, the adhesion of HL-60 cells to TNF-alpha-induced HUVEC was significantly decreased in a concentration-dependent manner. TNF-alpha-induced intracellular ROS was markedly decreased by pretreatment with BA. Furthermore, BA significantly inhibited the translocation and transcriptional activity of NF-kappaB increased by TNF-alpha. In conclusion, these results suggested a vascular protective role of BA via inhibition of ROS and NF-kappaB activation in HUVEC. SN - 1090-2104 UR - https://www.unboundmedicine.com/medline/citation/19896462/Protective_role_of_betulinic_acid_on_TNF_alpha_induced_cell_adhesion_molecules_in_vascular_endothelial_cells_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(09)02168-8 DB - PRIME DP - Unbound Medicine ER -