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The different effects of i.c.v. injection of pituitary adenylate cyclase activating polypeptide (PACAP) on prolactin secretion in adult male and lactating rats.
Exp Anim. 2009 Oct; 58(5):489-95.EA

Abstract

The effects of intracerebroventricular (i.c.v.) administration of pituitary adenylate cyclase activating polypeptide38 (PACAP38) on prolactin (PRL) secretion and the activity of tyrosine hydroxylase (TH) were examined in adult male and lactating rats with or without suckling stimulus. In adult male rats and lactating rats with suckling stimulus, administration of PACAP38 (0.25 or 1 nmol) decreased PRL secretion and increased the activity of TH in the stalk-median eminence. On the other hand, the injection of PACAP38 did not affect PRL secretion and TH activity in lactating rats without sucking stimulus. Administration of PACAP6-38 (4 nmol), a specific receptor antagonist, also had no effect on PRL secretion and TH activity in adult male rats. These results suggest that i.c.v. administration of PACAP inhibits PRL secretion mediated by dopamine neuron within the hypothalamus, but the effects of PACAP differ depending on the physiological condition of animals. These observed effects of PACAP on PRL release may be pharmacological responses rather than physiological responses.

Authors+Show Affiliations

Laboratory Animal Research Center, Dokkyo Medical University, Mibu, Tochigi, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19897932

Citation

Tohei, Atsushi, et al. "The Different Effects of I.c.v. Injection of Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) On Prolactin Secretion in Adult Male and Lactating Rats." Experimental Animals, vol. 58, no. 5, 2009, pp. 489-95.
Tohei A, Ikeda M, Hokao R, et al. The different effects of i.c.v. injection of pituitary adenylate cyclase activating polypeptide (PACAP) on prolactin secretion in adult male and lactating rats. Exp Anim. 2009;58(5):489-95.
Tohei, A., Ikeda, M., Hokao, R., & Shinoda, M. (2009). The different effects of i.c.v. injection of pituitary adenylate cyclase activating polypeptide (PACAP) on prolactin secretion in adult male and lactating rats. Experimental Animals, 58(5), 489-95.
Tohei A, et al. The Different Effects of I.c.v. Injection of Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) On Prolactin Secretion in Adult Male and Lactating Rats. Exp Anim. 2009;58(5):489-95. PubMed PMID: 19897932.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The different effects of i.c.v. injection of pituitary adenylate cyclase activating polypeptide (PACAP) on prolactin secretion in adult male and lactating rats. AU - Tohei,Atsushi, AU - Ikeda,Masashi, AU - Hokao,Ryoji, AU - Shinoda,Motoo, PY - 2009/11/10/entrez PY - 2009/11/10/pubmed PY - 2010/1/16/medline SP - 489 EP - 95 JF - Experimental animals JO - Exp Anim VL - 58 IS - 5 N2 - The effects of intracerebroventricular (i.c.v.) administration of pituitary adenylate cyclase activating polypeptide38 (PACAP38) on prolactin (PRL) secretion and the activity of tyrosine hydroxylase (TH) were examined in adult male and lactating rats with or without suckling stimulus. In adult male rats and lactating rats with suckling stimulus, administration of PACAP38 (0.25 or 1 nmol) decreased PRL secretion and increased the activity of TH in the stalk-median eminence. On the other hand, the injection of PACAP38 did not affect PRL secretion and TH activity in lactating rats without sucking stimulus. Administration of PACAP6-38 (4 nmol), a specific receptor antagonist, also had no effect on PRL secretion and TH activity in adult male rats. These results suggest that i.c.v. administration of PACAP inhibits PRL secretion mediated by dopamine neuron within the hypothalamus, but the effects of PACAP differ depending on the physiological condition of animals. These observed effects of PACAP on PRL release may be pharmacological responses rather than physiological responses. SN - 1881-7122 UR - https://www.unboundmedicine.com/medline/citation/19897932/The_different_effects_of_i_c_v__injection_of_pituitary_adenylate_cyclase_activating_polypeptide__PACAP__on_prolactin_secretion_in_adult_male_and_lactating_rats_ L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/expanim/58.489?lang=en&from=PubMed DB - PRIME DP - Unbound Medicine ER -