Tags

Type your tag names separated by a space and hit enter

Specific dermatologic features of the polycystic ovary syndrome and its association with biochemical markers of the metabolic syndrome and hyperandrogenism.
Acta Obstet Gynecol Scand. 2010; 89(2):199-204.AO

Abstract

OBJECTIVE

To investigate biochemical and metabolic abnormalities in relation with cutaneous features of polycystic ovary syndrome (PCOS).

DESIGN

Prospective descriptive analysis.

SETTING

University-based tertiary care.

SAMPLE

One-hundred and fifteen untreated consecutive women diagnosed as having PCOS.

METHODS

Each woman underwent an evaluation of body habitus, acne, hirsutism, seborrhea, androgenic alopecia and acanthosis nigricans. Associations between cutaneous features and hormonal and metabolic parameters were analyzed by means of multivariate logistic regression models.

MAIN OUTCOME MEASURES

Prevalence of cutaneous features in PCOS and associations among the features and biochemical and metabolic parameters.

RESULTS

The prevalence of acne, hirsutism, seborrhea, androgenetic alopecia and acanthosis nigricans was 53%, 73.9%, 34.8%, 34.8% and 5.2%, respectively. Acne was not associated with the hormonal, metabolic and anthropometric variables. Hirsutism had positive associations with total testosterone, fasting glucose and total cholesterol, and a negative association with age. Seborrhea was found to be related with free testosterone, fasting glucose and insulin. A negative association was determined among androgenic alopecia and free testosterone, low-density lipoprotein and insulin.

CONCLUSIONS

Acne and androgenic alopecia are not good markers for the hyperandrogenism in PCOS. Hirsutism appears to be strongly related with hyperandrogenism and metabolic abnormalities in PCOS women.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Ozdemir S
Department of Gynecology and Obstetrics, Meram Medical Faculty, Selçuk University, Konya, Turkey. snmstf@yahoo.com
Ozdemir M
No affiliation info available
Görkemli H
No affiliation info available
Kiyici A
No affiliation info available
Bodur S
No affiliation info available

MeSH

AdolescentAdultBiomarkersBlood GlucoseCholesterolDehydroepiandrosterone SulfateEstradiolFemaleHomeostasisHumansHyperandrogenismInsulinLuteinizing HormoneMetabolic SyndromeMultivariate AnalysisPolycystic Ovary SyndromeProspective StudiesSex Hormone-Binding GlobulinSkin DiseasesTestosterone

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19900078

Citation

Ozdemir, Suna, et al. "Specific Dermatologic Features of the Polycystic Ovary Syndrome and Its Association With Biochemical Markers of the Metabolic Syndrome and Hyperandrogenism." Acta Obstetricia Et Gynecologica Scandinavica, vol. 89, no. 2, 2010, pp. 199-204.
Ozdemir S, Ozdemir M, Görkemli H, et al. Specific dermatologic features of the polycystic ovary syndrome and its association with biochemical markers of the metabolic syndrome and hyperandrogenism. Acta Obstet Gynecol Scand. 2010;89(2):199-204.
Ozdemir, S., Ozdemir, M., Görkemli, H., Kiyici, A., & Bodur, S. (2010). Specific dermatologic features of the polycystic ovary syndrome and its association with biochemical markers of the metabolic syndrome and hyperandrogenism. Acta Obstetricia Et Gynecologica Scandinavica, 89(2), 199-204. https://doi.org/10.3109/00016340903353284
Ozdemir S, et al. Specific Dermatologic Features of the Polycystic Ovary Syndrome and Its Association With Biochemical Markers of the Metabolic Syndrome and Hyperandrogenism. Acta Obstet Gynecol Scand. 2010;89(2):199-204. PubMed PMID: 19900078.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Specific dermatologic features of the polycystic ovary syndrome and its association with biochemical markers of the metabolic syndrome and hyperandrogenism. AU - Ozdemir,Suna, AU - Ozdemir,Mustafa, AU - Görkemli,Hüseyin, AU - Kiyici,Aysel, AU - Bodur,Sait, PY - 2009/11/11/entrez PY - 2009/11/11/pubmed PY - 2010/3/5/medline SP - 199 EP - 204 JF - Acta obstetricia et gynecologica Scandinavica JO - Acta Obstet Gynecol Scand VL - 89 IS - 2 N2 - OBJECTIVE: To investigate biochemical and metabolic abnormalities in relation with cutaneous features of polycystic ovary syndrome (PCOS). DESIGN: Prospective descriptive analysis. SETTING: University-based tertiary care. SAMPLE: One-hundred and fifteen untreated consecutive women diagnosed as having PCOS. METHODS: Each woman underwent an evaluation of body habitus, acne, hirsutism, seborrhea, androgenic alopecia and acanthosis nigricans. Associations between cutaneous features and hormonal and metabolic parameters were analyzed by means of multivariate logistic regression models. MAIN OUTCOME MEASURES: Prevalence of cutaneous features in PCOS and associations among the features and biochemical and metabolic parameters. RESULTS: The prevalence of acne, hirsutism, seborrhea, androgenetic alopecia and acanthosis nigricans was 53%, 73.9%, 34.8%, 34.8% and 5.2%, respectively. Acne was not associated with the hormonal, metabolic and anthropometric variables. Hirsutism had positive associations with total testosterone, fasting glucose and total cholesterol, and a negative association with age. Seborrhea was found to be related with free testosterone, fasting glucose and insulin. A negative association was determined among androgenic alopecia and free testosterone, low-density lipoprotein and insulin. CONCLUSIONS: Acne and androgenic alopecia are not good markers for the hyperandrogenism in PCOS. Hirsutism appears to be strongly related with hyperandrogenism and metabolic abnormalities in PCOS women. SN - 1600-0412 UR - https://www.unboundmedicine.com/medline/citation/19900078/Specific_dermatologic_features_of_the_polycystic_ovary_syndrome_and_its_association_with_biochemical_markers_of_the_metabolic_syndrome_and_hyperandrogenism_ DB - PRIME DP - Unbound Medicine ER -