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Serum apolipoprotein C-III in high-density lipoprotein: a key diabetogenic risk factor in Turks.
Diabet Med. 2009 Oct; 26(10):981-8.DM

Abstract

AIMS

We studied determinants of serum apolipoprotein C-III (apoC-III) and whether levels of apoC-III or its fractions predict metabolic syndrome (MetS), Type 2 diabetes and coronary heart disease (CHD).

METHODS

The predictive value of apoC-III, measured by immunoturbimetric immunoassay in 802 tracked individuals of a Turkish general population in determining cardiometabolic risk was assessed over 4.4 +/- 1.2 years' follow-up. Patients with MetS, Type 2 diabetes and CHD at baseline were excluded.

RESULTS

Total apoC-III, as well as both fractions, was significantly, linearly and inversely related to smoking status, positively to alcohol usage and to levels of complement C3. Mid and high tertiles of total or non-high density lipoprotein (HDL) apoC-III predicted significantly and independently incident MetS; they predicted CHD with risk ratios of 1.6 [95% confidence intervals (CI) 1.02-2.5], for 1 sd increment, after adjustments that included HDL cholesterol and body mass index (BMI). The highest tertile of HDL apoC-III was a major independent predictor of new-onset diabetes with a 2.5-fold risk ratio for 1 sd increment (95% CI 1.5-4.0) in combined sexes, after adjustment for waist circumference, HDL cholesterol and other confounders and was a better predictor than waist girth.

CONCLUSIONS

Serum total apoC-III or its fractions are linearly and inversely associated with smoking, positively with alcohol usage and serum complement C3. The presumably dysfunctional HDL apoC-III is a stronger predictor of Type 2 diabetes than waist girth in Turks. Non-HDL apoC-III predicts strongly the development of MetS as well as incident CHD, independent of HDL cholesterol, BMI and non-lipid factors. The atherogenicity of apoC-III and dysfunctionality of HDL apoC-III carry huge public health implications in Turks.

Authors+Show Affiliations

Turkish Society of Cardiology, Department of Cardiology, Cerrahpaşa Medical Faculty, Istanbul University, Turkey. alt_onat@yahoo.com.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19900229

Citation

Onat, A, et al. "Serum Apolipoprotein C-III in High-density Lipoprotein: a Key Diabetogenic Risk Factor in Turks." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 26, no. 10, 2009, pp. 981-8.
Onat A, Hergenç G, Ayhan E, et al. Serum apolipoprotein C-III in high-density lipoprotein: a key diabetogenic risk factor in Turks. Diabet Med. 2009;26(10):981-8.
Onat, A., Hergenç, G., Ayhan, E., Uğur, M., Kaya, H., Tuncer, M., & Can, G. (2009). Serum apolipoprotein C-III in high-density lipoprotein: a key diabetogenic risk factor in Turks. Diabetic Medicine : a Journal of the British Diabetic Association, 26(10), 981-8. https://doi.org/10.1111/j.1464-5491.2009.02814.x
Onat A, et al. Serum Apolipoprotein C-III in High-density Lipoprotein: a Key Diabetogenic Risk Factor in Turks. Diabet Med. 2009;26(10):981-8. PubMed PMID: 19900229.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum apolipoprotein C-III in high-density lipoprotein: a key diabetogenic risk factor in Turks. AU - Onat,A, AU - Hergenç,G, AU - Ayhan,E, AU - Uğur,M, AU - Kaya,H, AU - Tuncer,M, AU - Can,G, PY - 2009/11/11/entrez PY - 2009/11/11/pubmed PY - 2010/5/12/medline SP - 981 EP - 8 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet Med VL - 26 IS - 10 N2 - AIMS: We studied determinants of serum apolipoprotein C-III (apoC-III) and whether levels of apoC-III or its fractions predict metabolic syndrome (MetS), Type 2 diabetes and coronary heart disease (CHD). METHODS: The predictive value of apoC-III, measured by immunoturbimetric immunoassay in 802 tracked individuals of a Turkish general population in determining cardiometabolic risk was assessed over 4.4 +/- 1.2 years' follow-up. Patients with MetS, Type 2 diabetes and CHD at baseline were excluded. RESULTS: Total apoC-III, as well as both fractions, was significantly, linearly and inversely related to smoking status, positively to alcohol usage and to levels of complement C3. Mid and high tertiles of total or non-high density lipoprotein (HDL) apoC-III predicted significantly and independently incident MetS; they predicted CHD with risk ratios of 1.6 [95% confidence intervals (CI) 1.02-2.5], for 1 sd increment, after adjustments that included HDL cholesterol and body mass index (BMI). The highest tertile of HDL apoC-III was a major independent predictor of new-onset diabetes with a 2.5-fold risk ratio for 1 sd increment (95% CI 1.5-4.0) in combined sexes, after adjustment for waist circumference, HDL cholesterol and other confounders and was a better predictor than waist girth. CONCLUSIONS: Serum total apoC-III or its fractions are linearly and inversely associated with smoking, positively with alcohol usage and serum complement C3. The presumably dysfunctional HDL apoC-III is a stronger predictor of Type 2 diabetes than waist girth in Turks. Non-HDL apoC-III predicts strongly the development of MetS as well as incident CHD, independent of HDL cholesterol, BMI and non-lipid factors. The atherogenicity of apoC-III and dysfunctionality of HDL apoC-III carry huge public health implications in Turks. SN - 1464-5491 UR - https://www.unboundmedicine.com/medline/citation/19900229/Serum_apolipoprotein_C_III_in_high_density_lipoprotein:_a_key_diabetogenic_risk_factor_in_Turks_ L2 - https://doi.org/10.1111/j.1464-5491.2009.02814.x DB - PRIME DP - Unbound Medicine ER -