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Study of the critical points of experimental HPMC-NaCMC hydrophilic matrices.
Int J Pharm. 2010 Feb 15; 386(1-2):52-60.IJ

Abstract

The purpose of the present work was to study the existence of critical points on the drug release and water uptake behaviour of ternary hydrophilic matrix tablets and to study the possibility of simplifying a ternary to a binary system. The ternary hydrophilic matrix tablets were prepared between 40 and 100% (w/w) of KCl, HPMC and NaCMC. Dissolution studies were carried out using the paddle method and the water uptake studies were measured using the modified Enslin apparatus and the behaviour of the kinetic parameters was studied. According to the percolation theory, both studies confirm the existence of critical points; those were related to the excipients percolation tresholds. The percolation thresholds for the binary hydrophilic matrix tablets were found between 28.7-40.7% (v/v) of HPMC and 38.6-53.9% (v/v) of NaCMC. For the ternary hydrophilic matrix tablets, the existence of a critical barrier between 54 and 61% (v/v) KCl (60-70%, w/w of KCl) was found. In the studied ternary systems HPMC and NaCMC showed that is not possible to simplify the system but they present a partial collaboration in order to establish the gel layer. The knowledge of this critical barrier will be useful in order to optimize the design of the ternary hydrophilic matrix systems.

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Authors+Show Affiliations

Contreras L
Department of Pharmacy and Pharmaceutical Technology, University of Seville, 41012 Seville, Spain. lcontreraschavez@yahoo.com
Melgoza LM
No affiliation info available
Villalobos R
No affiliation info available
Caraballo I
No affiliation info available

MeSH

Carboxymethylcellulose SodiumChemistry, PharmaceuticalDrug CompoundingExcipientsGelsHypromellose DerivativesKineticsMethylcelluloseModels, ChemicalPotassium ChlorideSolubilitySurface PropertiesTabletsTechnology, PharmaceuticalWater

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19900524

Citation

Contreras, L, et al. "Study of the Critical Points of Experimental HPMC-NaCMC Hydrophilic Matrices." International Journal of Pharmaceutics, vol. 386, no. 1-2, 2010, pp. 52-60.
Contreras L, Melgoza LM, Villalobos R, et al. Study of the critical points of experimental HPMC-NaCMC hydrophilic matrices. Int J Pharm. 2010;386(1-2):52-60.
Contreras, L., Melgoza, L. M., Villalobos, R., & Caraballo, I. (2010). Study of the critical points of experimental HPMC-NaCMC hydrophilic matrices. International Journal of Pharmaceutics, 386(1-2), 52-60. https://doi.org/10.1016/j.ijpharm.2009.10.048
Contreras L, et al. Study of the Critical Points of Experimental HPMC-NaCMC Hydrophilic Matrices. Int J Pharm. 2010 Feb 15;386(1-2):52-60. PubMed PMID: 19900524.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Study of the critical points of experimental HPMC-NaCMC hydrophilic matrices. AU - Contreras,L, AU - Melgoza,L M, AU - Villalobos,R, AU - Caraballo,I, Y1 - 2009/11/10/ PY - 2009/07/03/received PY - 2009/10/25/revised PY - 2009/10/29/accepted PY - 2009/11/11/entrez PY - 2009/11/11/pubmed PY - 2010/4/9/medline SP - 52 EP - 60 JF - International journal of pharmaceutics JO - Int J Pharm VL - 386 IS - 1-2 N2 - The purpose of the present work was to study the existence of critical points on the drug release and water uptake behaviour of ternary hydrophilic matrix tablets and to study the possibility of simplifying a ternary to a binary system. The ternary hydrophilic matrix tablets were prepared between 40 and 100% (w/w) of KCl, HPMC and NaCMC. Dissolution studies were carried out using the paddle method and the water uptake studies were measured using the modified Enslin apparatus and the behaviour of the kinetic parameters was studied. According to the percolation theory, both studies confirm the existence of critical points; those were related to the excipients percolation tresholds. The percolation thresholds for the binary hydrophilic matrix tablets were found between 28.7-40.7% (v/v) of HPMC and 38.6-53.9% (v/v) of NaCMC. For the ternary hydrophilic matrix tablets, the existence of a critical barrier between 54 and 61% (v/v) KCl (60-70%, w/w of KCl) was found. In the studied ternary systems HPMC and NaCMC showed that is not possible to simplify the system but they present a partial collaboration in order to establish the gel layer. The knowledge of this critical barrier will be useful in order to optimize the design of the ternary hydrophilic matrix systems. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/19900524/Study_of_the_critical_points_of_experimental_HPMC_NaCMC_hydrophilic_matrices_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(09)00774-1 DB - PRIME DP - Unbound Medicine ER -