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Association between dietary fat intake and age-related macular degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS): an ancillary study of the Women's Health Initiative.

Abstract

OBJECTIVE

To evaluate the relationships between the amount and type of dietary fat and intermediate age-related macular degeneration (AMD).

DESIGN

Women aged 50 to 79 years with high and low lutein intake from 3 sites of the Women's Health Initiative Observational Study were recruited into the Carotenoids in Age-Related Eye Disease Study. Fat intake from 1994 through 1998 was estimated using food frequency questionnaires, and AMD was assessed photographically from 2001 through 2004.

RESULTS

Intakes of omega-6 and omega-3 polyunsaturated fatty acids, which were highly correlated (r = 0.8), were associated with approximately 2-fold higher prevalence of intermediate AMD in high vs low quintiles. However, monounsaturated fatty acid intake was associated with lower prevalence. Age interactions were often observed. In women younger than 75 years (n = 1325), total fat and saturated fatty acid intakes were associated with increased prevalence of AMD (multivariate adjusted odds ratios [95% confidence interval] for intermediate AMD, 1.7 [1.0-2.7] for quintile 5 vs quintile 1 for total fat [P = .10 for trend] and 1.6 [0.7-3.6] for saturated fatty acids [P = .23 for trend]). The associations were reversed in older women.

CONCLUSIONS

These results support a growing body of evidence suggesting that diets high in several types of fat may contribute to the risk of intermediate AMD and that diets high in monounsaturated fatty acids may be protective.

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  • Authors+Show Affiliations

    ,

    Department of Nutrition, Food Studies, and Public Health, New York University, New York, New York, USA.

    , , , , , , ,

    Source

    MeSH

    Aged
    Dietary Fats
    Fatty Acids
    Fatty Acids, Omega-3
    Fatty Acids, Omega-6
    Fatty Acids, Unsaturated
    Feeding Behavior
    Female
    Humans
    Lutein
    Macular Degeneration
    Middle Aged
    Prevalence
    Risk Factors
    Surveys and Questionnaires
    United States
    Women's Health

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19901214

    Citation

    Parekh, Niyati, et al. "Association Between Dietary Fat Intake and Age-related Macular Degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS): an Ancillary Study of the Women's Health Initiative." Archives of Ophthalmology (Chicago, Ill. : 1960), vol. 127, no. 11, 2009, pp. 1483-93.
    Parekh N, Voland RP, Moeller SM, et al. Association between dietary fat intake and age-related macular degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS): an ancillary study of the Women's Health Initiative. Arch Ophthalmol. 2009;127(11):1483-93.
    Parekh, N., Voland, R. P., Moeller, S. M., Blodi, B. A., Ritenbaugh, C., Chappell, R. J., ... Mares, J. A. (2009). Association between dietary fat intake and age-related macular degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS): an ancillary study of the Women's Health Initiative. Archives of Ophthalmology (Chicago, Ill. : 1960), 127(11), pp. 1483-93. doi:10.1001/archophthalmol.2009.130.
    Parekh N, et al. Association Between Dietary Fat Intake and Age-related Macular Degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS): an Ancillary Study of the Women's Health Initiative. Arch Ophthalmol. 2009;127(11):1483-93. PubMed PMID: 19901214.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association between dietary fat intake and age-related macular degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS): an ancillary study of the Women's Health Initiative. AU - Parekh,Niyati, AU - Voland,Rickie P, AU - Moeller,Suzen M, AU - Blodi,Barbara A, AU - Ritenbaugh,Cheryl, AU - Chappell,Richard J, AU - Wallace,Robert B, AU - Mares,Julie A, AU - ,, PY - 2009/11/11/entrez PY - 2009/11/11/pubmed PY - 2009/11/18/medline SP - 1483 EP - 93 JF - Archives of ophthalmology (Chicago, Ill. : 1960) JO - Arch. Ophthalmol. VL - 127 IS - 11 N2 - OBJECTIVE: To evaluate the relationships between the amount and type of dietary fat and intermediate age-related macular degeneration (AMD). DESIGN: Women aged 50 to 79 years with high and low lutein intake from 3 sites of the Women's Health Initiative Observational Study were recruited into the Carotenoids in Age-Related Eye Disease Study. Fat intake from 1994 through 1998 was estimated using food frequency questionnaires, and AMD was assessed photographically from 2001 through 2004. RESULTS: Intakes of omega-6 and omega-3 polyunsaturated fatty acids, which were highly correlated (r = 0.8), were associated with approximately 2-fold higher prevalence of intermediate AMD in high vs low quintiles. However, monounsaturated fatty acid intake was associated with lower prevalence. Age interactions were often observed. In women younger than 75 years (n = 1325), total fat and saturated fatty acid intakes were associated with increased prevalence of AMD (multivariate adjusted odds ratios [95% confidence interval] for intermediate AMD, 1.7 [1.0-2.7] for quintile 5 vs quintile 1 for total fat [P = .10 for trend] and 1.6 [0.7-3.6] for saturated fatty acids [P = .23 for trend]). The associations were reversed in older women. CONCLUSIONS: These results support a growing body of evidence suggesting that diets high in several types of fat may contribute to the risk of intermediate AMD and that diets high in monounsaturated fatty acids may be protective. SN - 1538-3601 UR - https://www.unboundmedicine.com/medline/citation/19901214/Association_between_dietary_fat_intake_and_age_related_macular_degeneration_in_the_Carotenoids_in_Age_Related_Eye_Disease_Study__CAREDS_:_an_ancillary_study_of_the_Women's_Health_Initiative_ L2 - https://jamanetwork.com/journals/jamaophthalmology/fullarticle/10.1001/archophthalmol.2009.130 DB - PRIME DP - Unbound Medicine ER -