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Modelling of diclofenac sodium diffusion from swellable and water-soluble polyethylene oxide matrices.
J Pharm Pharmacol. 2009 Nov; 61(11):1449-56.JP

Abstract

OBJECTIVES

The main objective of this study was to develop a mathematical model for the characterization of diclofenac sodium diffusion from polyethylene oxide (PEO) matrices. A model was developed on the basis of the diffusion theory accounting for the characteristics of the polymer: swelling with subsequent dissolution in water. The concentration-dependent diffusion of drug and water was taken into account. Experimental data were analysed using a computer software program as an aid for solving partial differential equations.

METHODS

Six formulations of matrix tablets with different drug-excipient ratios were prepared using low-molecular-weight PEO as a matrix-forming material. For obtaining drug release data, dissolution studies were performed and water uptake by pure PEO matrices was studied as well.

KEY FINDINGS

A good agreement of the developed model with experimental results was demonstrated. Some anomalies in drug diffusion were observed and their origin was questioned. Changes in the parameters characterizing the process of diffusion are attributed to glassy-rubbery polymer transitions. Additional interpretation of this phenomenon on the basis of percolation theory is also provided.

CONCLUSIONS

The obtained model has the ability to predict the required characteristics of matrices for desired drug release. The composition of batches with undesirable release properties can be predetermined and avoided in manufacturing.

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Authors+Show Affiliations

Petrović J
Institute of Pharmaceutical Technology, Faculty of Pharmacy, Belgrade, Serbia. jpetrovic@pharmacy.bg.ac.rs
Jocković J
No affiliation info available
Ibrić S
No affiliation info available
Durić Z
No affiliation info available

MeSH

Anti-Inflammatory Agents, Non-SteroidalDiclofenacDiffusionDrug Delivery SystemsExcipientsModels, TheoreticalMolecular WeightPolyethylene GlycolsSolubilityTabletsWater

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Validation Study

Language

eng

PubMed ID

19903369

Citation

Petrović, Jelena, et al. "Modelling of Diclofenac Sodium Diffusion From Swellable and Water-soluble Polyethylene Oxide Matrices." The Journal of Pharmacy and Pharmacology, vol. 61, no. 11, 2009, pp. 1449-56.
Petrović J, Jocković J, Ibrić S, et al. Modelling of diclofenac sodium diffusion from swellable and water-soluble polyethylene oxide matrices. J Pharm Pharmacol. 2009;61(11):1449-56.
Petrović, J., Jocković, J., Ibrić, S., & Durić, Z. (2009). Modelling of diclofenac sodium diffusion from swellable and water-soluble polyethylene oxide matrices. The Journal of Pharmacy and Pharmacology, 61(11), 1449-56. https://doi.org/10.1211/jpp/61.11.0003
Petrović J, et al. Modelling of Diclofenac Sodium Diffusion From Swellable and Water-soluble Polyethylene Oxide Matrices. J Pharm Pharmacol. 2009;61(11):1449-56. PubMed PMID: 19903369.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modelling of diclofenac sodium diffusion from swellable and water-soluble polyethylene oxide matrices. AU - Petrović,Jelena, AU - Jocković,Jelena, AU - Ibrić,Svetlana, AU - Durić,Zorica, PY - 2009/11/12/entrez PY - 2009/11/12/pubmed PY - 2010/3/17/medline SP - 1449 EP - 56 JF - The Journal of pharmacy and pharmacology JO - J Pharm Pharmacol VL - 61 IS - 11 N2 - OBJECTIVES: The main objective of this study was to develop a mathematical model for the characterization of diclofenac sodium diffusion from polyethylene oxide (PEO) matrices. A model was developed on the basis of the diffusion theory accounting for the characteristics of the polymer: swelling with subsequent dissolution in water. The concentration-dependent diffusion of drug and water was taken into account. Experimental data were analysed using a computer software program as an aid for solving partial differential equations. METHODS: Six formulations of matrix tablets with different drug-excipient ratios were prepared using low-molecular-weight PEO as a matrix-forming material. For obtaining drug release data, dissolution studies were performed and water uptake by pure PEO matrices was studied as well. KEY FINDINGS: A good agreement of the developed model with experimental results was demonstrated. Some anomalies in drug diffusion were observed and their origin was questioned. Changes in the parameters characterizing the process of diffusion are attributed to glassy-rubbery polymer transitions. Additional interpretation of this phenomenon on the basis of percolation theory is also provided. CONCLUSIONS: The obtained model has the ability to predict the required characteristics of matrices for desired drug release. The composition of batches with undesirable release properties can be predetermined and avoided in manufacturing. SN - 2042-7158 UR - https://www.unboundmedicine.com/medline/citation/19903369/Modelling_of_diclofenac_sodium_diffusion_from_swellable_and_water_soluble_polyethylene_oxide_matrices_ L2 - https://doi.org/10.1211/jpp/61.11.0003 DB - PRIME DP - Unbound Medicine ER -