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The role of serum PRL bioactivity evaluation in hyperprolactinaemic women with different menstrual disorders.
Gynecol Endocrinol. 2009 Dec; 25(12):799-806.GE

Abstract

OBJECTIVE

The objective of the study was to characterize the bioactivity of prolactin (PRL) in hyperprolactinaemic patients with prolactinomas, irregular menstrual cycles, regular menstrual cycles and PCOS.

METHODS

Serum PRL, biological activity of PRL (after polyethylene glycol (PEG) precipitation) and serum follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), testosterone (T), thyroid-stimulating hormone (TSH) concentrations were measured in all hyperprolactinaemic patients and control group (healthy subjects). Correlations between active PRL (PRL-PEG) and serum FSH, LH, E2, T, TSH concentrations were also evaluated.

RESULTS

Prolactinoma is characterized by high serum PRL levels and its high biological activity. Hyperprolactinaemic patients with irregular cycles were characterized by high biological activity of PRL. Patients with hyperprolactinaemia and regular cycles had low biological activity of PRL.

CONCLUSIONS

Diagnosis of hyperprolactinaemia should be associated with estimation of PRL biological activity because it is important for type of hyperprolactinaemia management. Low biological activity of PRL does not impair FSH and LH secretion and does not cause hypoestrogenism.

Authors+Show Affiliations

Department of Gynecological Endocrinology, Poznan University of Medical Sciences, Poznan, Poland.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19905999

Citation

Kostrzak, A, et al. "The Role of Serum PRL Bioactivity Evaluation in Hyperprolactinaemic Women With Different Menstrual Disorders." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 25, no. 12, 2009, pp. 799-806.
Kostrzak A, Warenik-Szymankiewicz A, Meczekalski B. The role of serum PRL bioactivity evaluation in hyperprolactinaemic women with different menstrual disorders. Gynecol Endocrinol. 2009;25(12):799-806.
Kostrzak, A., Warenik-Szymankiewicz, A., & Meczekalski, B. (2009). The role of serum PRL bioactivity evaluation in hyperprolactinaemic women with different menstrual disorders. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 25(12), 799-806. https://doi.org/10.3109/09513590903209329
Kostrzak A, Warenik-Szymankiewicz A, Meczekalski B. The Role of Serum PRL Bioactivity Evaluation in Hyperprolactinaemic Women With Different Menstrual Disorders. Gynecol Endocrinol. 2009;25(12):799-806. PubMed PMID: 19905999.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of serum PRL bioactivity evaluation in hyperprolactinaemic women with different menstrual disorders. AU - Kostrzak,A, AU - Warenik-Szymankiewicz,A, AU - Meczekalski,B, PY - 2009/11/13/entrez PY - 2009/11/13/pubmed PY - 2010/1/27/medline SP - 799 EP - 806 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol Endocrinol VL - 25 IS - 12 N2 - OBJECTIVE: The objective of the study was to characterize the bioactivity of prolactin (PRL) in hyperprolactinaemic patients with prolactinomas, irregular menstrual cycles, regular menstrual cycles and PCOS. METHODS: Serum PRL, biological activity of PRL (after polyethylene glycol (PEG) precipitation) and serum follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), testosterone (T), thyroid-stimulating hormone (TSH) concentrations were measured in all hyperprolactinaemic patients and control group (healthy subjects). Correlations between active PRL (PRL-PEG) and serum FSH, LH, E2, T, TSH concentrations were also evaluated. RESULTS: Prolactinoma is characterized by high serum PRL levels and its high biological activity. Hyperprolactinaemic patients with irregular cycles were characterized by high biological activity of PRL. Patients with hyperprolactinaemia and regular cycles had low biological activity of PRL. CONCLUSIONS: Diagnosis of hyperprolactinaemia should be associated with estimation of PRL biological activity because it is important for type of hyperprolactinaemia management. Low biological activity of PRL does not impair FSH and LH secretion and does not cause hypoestrogenism. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/19905999/The_role_of_serum_PRL_bioactivity_evaluation_in_hyperprolactinaemic_women_with_different_menstrual_disorders_ L2 - https://www.tandfonline.com/doi/full/10.3109/09513590903209329 DB - PRIME DP - Unbound Medicine ER -